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    ROSUVASTATIN CALCIUM INTERMEDIATE AND PREPARATION METHOD THEREOF
    1.
    发明公开
    ROSUVASTATIN CALCIUM INTERMEDIATE AND PREPARATION METHOD THEREOF 有权
    ROSUVASTATIN钙中间体及其制备方法

    公开(公告)号：EP2557084A1

    公开(公告)日：2013-02-13

    申请号：EP10849287.7

    申请日：2010-07-28

    申请人： Porton Fine Chemicals Ltd

    发明人： LIN, Wenqing ,  ZHENG, Hongjie ,  LIU, Xiaobo

    IPC分类号： C07F9/535 ,  C07F7/02 ,  C07C69/716 ,  C07C69/738 ,  C07C69/732

    CPC分类号： C07F9/5352 ,  C07C29/36 ,  C07C67/22 ,  C07C67/29 ,  C07C67/31 ,  C07C67/313 ,  C07C69/732 ,  C07C69/734 ,  C07C69/78 ,  Y02P20/55 ,  C07C33/423

    摘要： A rosuvastatin calcium intermediate as shown by Formula I is prepared as follow: a) subjecting chloroethylene, magnesium and R-epoxy chloropropane to Grignard reaction, b) adding sodium cyanide for nucleophilic substitution reaction, c) adding alcohol for alcoholysis reaction, d) adding alkaline solvent for hydroxyl protection, e) subjecting the mixture to oxidation reaction, f) adding triphenyl phosphorus and subjecting to Wittig reaction in the presence of alkali to obtain the compound of formula I. The method has moderate reaction conditions, is convenient and stable and can be applied to industrial production.

    摘要翻译： 式I所示的瑞舒伐他汀钙中间体如下制备：a）使氯乙烯，镁和R-环氧氯丙烷进行格氏反应，b）加入氰化钠进行亲核取代反应，c）加入醇进行醇解反应，d）加入 e）将混合物进行氧化反应，f）加入三苯基磷并在碱存在下进行维g希反应，得到式I化合物。该方法反应条件温和，方便稳定， 可以应用于工业生产。

    CYCLOPENTADIENYLPHOSPHAZEN-KOMPLEXE (CpPN-KOMPLEXE) VON METALLEN DER 3. UND 4. GRUPPE UND DER LANTHANOIDE
    2.
    发明公开
    CYCLOPENTADIENYLPHOSPHAZEN-KOMPLEXE (CpPN-KOMPLEXE) VON METALLEN DER 3. UND 4. GRUPPE UND DER LANTHANOIDE 有权
    Cyclopentadienylphosphazene-COMPLEX（CpPN COMPLEX）第3次和第4族和镧系元素族的金属

    公开(公告)号：EP2227479A2

    公开(公告)日：2010-09-15

    申请号：EP08853711.3

    申请日：2008-11-25

    申请人： Philipps-Universität Marburg

    发明人： SUNDERMEYER, Jörg ,  RUFANOV, Konstantin ,  PETROV, Alexander ,  ELFFERDING, Michael ,  WINKENSTETTE, Manuel

    IPC分类号： C07F17/00 ,  C07F9/6581 ,  C08F4/00

    CPC分类号： C07F17/00 ,  C07F9/5352 ,  C07F9/5355 ,  C08F4/65908 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/02 ,  C08F2420/01 ,  C08F4/6592 ,  C08F4/52

    摘要： The invention relates to cyclopentadienylphosphazene complexes (CpPN complexes) of metals of the III. and VI. group and of the lanthanoids except for lutetium. The complexes of the invention are isolobal and isoelectric with respect to the [(CpSiN)TiR2] complexes. There is exactly one CpPN moiety in the complexes of the invention. The cyclopentadienyl moiety of CpPN represents a monodentate, anionic ligand of the metal atom in all complexes of the invention. The metal atom is also bound to other anionic ligands. In a preferred embodiment, both the cyclopenadienyl moiety and the nitrogen atom within CpPN bind to the metal atom so that CpPN represents a bidentate ligand. Complexes in which CpN represents a bidentate ligand are CpPN Constrained Geometry Complexes (CpPN-CGC). The invention also relates to methods for producing the complexes in situ. The CpPN complexes can be electrically neutral or be present as cationic complexes. Cationic complexes are formed when one of the other anionic ligands of the metal atom is replaced by a neutral ligand; counterions of the cationic CpPN complexes are preferably fluoroborate, tetraphenyl borate, tetrakis-(3,5-trifluormethylphenyl)borate. The complexes are produced in situ by reacting a metal halide with a protonated cyclopentadienylphosphazene CpPNH and an alkaline or alkaline earth salt of the desired other anionic ligand. The complexes according to the invention can be used as catalysts for the hydroamination and polymerization of polyolefins.

    VERFAHREN ZUR HERSTELLUNG VON alpha-CHLOR-METHYLEN-TRIORGANYLPHOSPHORAN-DERIVATEN
    7.
    发明授权
    VERFAHREN ZUR HERSTELLUNG VON alpha-CHLOR-METHYLEN-TRIORGANYLPHOSPHORAN-DERIVATEN 失效
    用于生产α-氯代亚甲基衍生物TRIORGANYLPHOSPHORAN

    公开(公告)号：EP0603225B1

    公开(公告)日：1997-06-04

    申请号：EP92918319.2

    申请日：1992-09-01

    申请人： BASF Aktiengesellschaft

    发明人： SCHAEFER, Bernd ,  BUSCHMANN, Ernst ,  REISSENWEBER, Gernot

    IPC分类号： C07F9/535

    CPC分类号： C07F9/5352

    摘要： A process is disclosed for producing α-chlor-methylen-triorganylphosphorane carboxylic acid derivatives having the formula (I), in which R stands for C organic substituents; A stands for CN or CO-B; B stands for C or O organic residues that remain inert in chlorinating conditions, by chlorinating phosphoranes having the formula (II) with chlorine. Chlorination is carried out in the presence of a mineral base as hydrogen chloride acceptor, whereas chlorine and the base are synchronously but separately introduced into the reaction mixture according to their consumption. The products (I) obtained by this process represent important intermediates for plant protective substances.

    Verfahren zur Herstellung von alpha-Chlor-phosphoryliden
    8.
    发明公开
    Verfahren zur Herstellung von alpha-Chlor-phosphoryliden 失效
    制备阿尔法氯化磷酸盐的方法

    公开(公告)号：EP0421225A3

    公开(公告)日：1991-11-21

    申请号：EP90118275.8

    申请日：1990-09-24

    申请人： BASF Aktiengesellschaft

    发明人： Schaefer, Bernd, Dr.

    IPC分类号： C07F9/535

    CPC分类号： C07F9/5352

    摘要： Herstellung von α-Chlor-phosphoryliden der Formel I
    in der die Reste Ar gleiche oder verschiedene Arylgruppen bedeuten und E für einen das Ylid (I) stabilisierenden Substituenten steht, durch Umsetzung eines Phosphoniumsalzes der allgemeinen Formel II
    in welcher Hal Chlor, Brom oder Iod bedeutet, mit einem Chlorierungs­mittel, indem man als Chlorierungsmittel Chlorkalk verwendet.