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1.发明公开
公开(公告)号：EP3388529A1
公开(公告)日：2018-10-17
申请号：EP18173838.6
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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2.发明公开
公开(公告)号：EP3388529A8
公开(公告)日：2018-12-26
申请号：EP18173838.6
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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3.发明授权
公开(公告)号：EP2358895B1
公开(公告)日：2018-05-30
申请号：EP09764426.4
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
IPC分类号： G01N33/573 , C12Q1/37 , C12Q1/56 , G01N33/86
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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