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1.发明公开
公开(公告)号：EP3823985A1
公开(公告)日：2021-05-26
申请号：EP19755458.7
申请日：2019-07-15
申请人： Baxalta Incorporated , Baxalta GmbH
IPC分类号： C07K14/755 , A61K48/00 , C12N15/86 , C12N9/64 , C12N15/864 , A61K38/37
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2.发明公开
公开(公告)号：EP3630974A1
公开(公告)日：2020-04-08
申请号：EP18731636.9
申请日：2018-05-22
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： HORLING, Franziska , LENGLER, Johannes , FALKNER, Falko-Gunther , ROTTENSTEINER, Hanspeter , SCHEIFLINGER, Friedrich
IPC分类号： C12N15/11 , C07K14/745 , C12N15/86 , A61K48/00
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公开(公告)号：EP3458477A1
公开(公告)日：2019-03-27
申请号：EP17730590.1
申请日：2017-05-16
申请人： Baxalta Incorporated , Baxalta GmbH
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4.发明公开
公开(公告)号：EP3388529A8
公开(公告)日：2018-12-26
申请号：EP18173838.6
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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公开(公告)号：EP2349342B1
公开(公告)日：2018-06-27
申请号：EP09752930.9
申请日：2009-10-16
申请人： Baxalta GmbH , Baxalta Incorporated
CPC分类号： A61K47/61 , A61K38/37 , A61K38/4846 , A61K47/60 , C12Y304/21021 , C12Y304/21022
摘要： The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood factor but exhibit biological activity similar to or better than molecules having a higher number of water soluble polymer moieties.
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6.发明授权
公开(公告)号：EP2358895B1
公开(公告)日：2018-05-30
申请号：EP09764426.4
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
IPC分类号： G01N33/573 , C12Q1/37 , C12Q1/56 , G01N33/86
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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公开(公告)号：EP2710377B8
公开(公告)日：2015-10-28
申请号：EP12725948.9
申请日：2012-05-18
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： FERRARI, Silvia , GRUBER, Bernadette , PLAIMAUER, Barbara , ROTTENSTEINER, Hanspeter , SCHEIFLINGER, Friedrich
IPC分类号： G01N33/564
CPC分类号： G01N33/564
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8.发明公开
公开(公告)号：EP3388529A1
公开(公告)日：2018-10-17
申请号：EP18173838.6
申请日：2009-12-03
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： VARADI, Katalin , ROTTENSTEINER, Hanspeter , TURECEK, Peter , SCHWARZ, Hans-Peter , SCHREINER, Jutta
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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9.发明授权GLYCOPOLYSIALYLATION OF PROTEINS OTHER THAN BLOOD COAGULATION PROTEINS 有权GLYCOPOLYSIALYLIERUNG VON PROTEINEN ANDERSERS ALS BLUTGERINNUNGSPROTEINEN
公开(公告)号：EP2459226B1
公开(公告)日：2016-06-29
申请号：EP10739386.0
申请日：2010-07-26
发明人： JAIN, Sanjay , GREGORIADIS, Gregory , DWIVEDI, Archana , NATH, Srijit , SIEKMANN, Juergen , HAIDER, Stefan , ROTTENSTEINER, Hanspeter , TURECEK, Peter
IPC分类号： A61K47/48
CPC分类号： A61K47/6455 , A61K47/60 , A61K47/61 , A61K47/65
摘要： A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.
摘要翻译： 将水溶性聚合物，特别是聚唾液酸（PSA）或修饰的PSA（mPSA）与不同于凝血蛋白的糖蛋白的氧化碳水化合物部分缀合或通过使氧化的碳水化合物部分接触而与神经节苷脂或药物递送系统 其中所述水溶性聚合物含有氨基氧基，并且在水溶性聚合物上的氧化碳水化合物部分和氨基氧基之间形成肟键，或者其中所述水溶性聚合物含有酰肼基，腙键是 形成在水溶性聚合物上的氧化碳水化合物部分和酰肼基团之间。 因此得到氨基氧基或酰肼 - 水溶性聚合物如PSA和mPSA的结合物，其中PSA或mPSA通过碳水化合物部分连接。
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公开(公告)号：EP2459224B1
公开(公告)日：2016-06-01
申请号：EP10738119.6
申请日：2010-07-26
申请人： Baxalta GmbH , Baxalta Incorporated
IPC分类号： A61K47/48
CPC分类号： A61K47/4823 , A61K38/37 , A61K38/4846 , A61K47/60 , A61K47/61 , C08B37/0006 , C12N9/6437 , C12N9/644 , C12N9/96 , C12Y304/21021 , C12Y304/21022
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