公开(公告)号：EP2470530A1

公开(公告)日：2012-07-04

申请号：EP10745249.2

申请日：2010-08-24

申请人： Bayer Pharma Aktiengesellschaft

发明人： FÜRSTNER, Chantal ,  KELDENICH, Jörg ,  KERN, Armin ,  DELBECK, Martina ,  KOLKHOF, Peter ,  KRETSCHMER, Axel ,  POOK, Elisabeth ,  SCHMECK, Carsten ,  TRÜBEL, Hubert

IPC分类号： C07D413/12 ,  C07D403/12 ,  C07D401/12 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4439 ,  A61P5/12 ,  A61P7/10 ,  A61P9/00

CPC分类号： C07D413/12 ,  C07D401/12 ,  C07D403/12

摘要： The present application relates to novel heterocyclic-substituted 1-carboylmethyl-3-aryl-1,2,4-triazol-5-ones, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular disorders. The compounds are vasopressin receptor antagonists.

公开(公告)号：EP2408754A1

公开(公告)日：2012-01-25

申请号：EP10707478.3

申请日：2010-03-09

申请人： Bayer Pharma Aktiengesellschaft

发明人： BRÜGGEMEIER, Ulf ,  FÜRSTNER, Chantal ,  GEISS, Volker ,  KELDENICH, Joerg ,  KERN, Armin ,  DELBECK, Martina ,  KOLKHOF, Peter ,  KRETSCHMER, Axel ,  POOK, Elisabeth ,  SCHMECK, Carsten ,  TRÜBEL, Hubert

IPC分类号： C07D249/12 ,  A61K31/4196 ,  A61P9/04 ,  A61P1/16

CPC分类号： C07D249/12

摘要： The present application relates to novel substituted phenylalanine derivatives, to methods for the production thereof, to the use thereof alone or in combination to treat and/or prevent illnesses, and to the use thereof to produce drugs for treating and/or preventing illnesses, in particular for treating and/or preventing cardiovascular diseases.

公开(公告)号：EP2408751A1

公开(公告)日：2012-01-25

申请号：EP10709419.5

申请日：2010-03-12

申请人： Bayer Pharma Aktiengesellschaft

发明人： BRÜGGEMEIER, Ulf ,  FÜRSTNER, Chantal ,  GEISS, Volker ,  KELDENICH, Jörg ,  KERN, Armin ,  DELBECK, Martina ,  KOLKHOF, Peter ,  KRETSCHMER, Axel ,  POOK, Elisabeth ,  SCHMECK, Carsten ,  TRÜBEL, Hubert

IPC分类号： C07D233/70 ,  C07D249/12 ,  C07D409/04 ,  C07D413/12 ,  A61K31/4166 ,  A61K31/4196 ,  A61K31/422 ,  A61P9/00

CPC分类号： C07D233/70 ,  A61K9/0095 ,  A61K9/2054 ,  A61K31/4166 ,  A61K31/4196 ,  A61K31/422 ,  A61K45/06 ,  C07D249/12 ,  C07D409/04 ,  C07D413/12 ,  A61K2300/00

摘要： The invention relates to novel, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to methods for producing the same, to the use thereof either alone or in combination in the treatment and/or prevention of diseases and to their use for producing drugs for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular diseases.

摘要翻译： 本申请涉及新的取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。