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公开(公告)号：EP3781565A1
公开(公告)日：2021-02-24
申请号：EP19720074.4
申请日：2019-04-15
发明人： WORTMANN, Lars , SAUTIER, Brice , EIS, Knut , BRIEM, Hans , BÖHNKE, Niels , VON NUSSBAUM, Franz , HILIG, Roman , BADER, Benjamin , SCHRÖDER, Jens , PETERSEN, Kirstin , LIENAU, Philip , WENGNER, Antje, Margret , MOOSMAYER, Dieter , WANG, Qiuwen
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
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公开(公告)号：EP2951175A1
公开(公告)日：2015-12-09
申请号：EP14701580.4
申请日：2014-01-29
发明人： KLAR, Ulrich , WORTMANN, Lars , KETTSCHAU, Georg , PÜHLER, Florian , LIENAU, Philip , SÜLZLE, Detlev
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D471/04
摘要： The present invention relates to substituted pyrazolopyrimidinylamino-indazole compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及本文所述和定义的通式I的取代的吡唑并嘧啶基氨基 - 吲唑化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述 用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的化合物。
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公开(公告)号：EP3402795B1
公开(公告)日：2019-10-30
申请号：EP17700500.6
申请日：2017-01-06
发明人： LÜCKING, Ulrich , KOPPITZ, Marcus , LEFRANC, Julien , WORTMANN, Lars , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BÖMER, Ulf , BADER, Benjamin , LIENAU, Philip , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
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公开(公告)号：EP3177619B1
公开(公告)日：2018-04-25
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619A1
公开(公告)日：2017-06-14
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的所述化合物的用途 疾病作为唯一的药剂或与其他活性成分组合。
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公开(公告)号：EP2852595B1
公开(公告)日：2016-06-22
申请号：EP13723163.5
申请日：2013-05-17
发明人： KLAR, Ulrich , KETTSCHAU, Georg , KOSEMUND, Dirk , PÜHLER, Florian , EIS, Knut , LIENAU, Philip , BÖMER, Ulf , SÜLZLE, Detlev , WORTMANN, Lars
IPC分类号： C07D495/04 , A61K31/38 , A61P35/00
CPC分类号： C07D495/04 , A61K31/38 , A61K31/519 , A61K45/06 , C07D519/00
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7.发明公开SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERFOLIFERATIVE DISORDERS 审中-公开取代的吲唑 - 吡咯并嘧啶类化合物用于治疗超分化疾病
公开(公告)号：EP2900670A1
公开(公告)日：2015-08-05
申请号：EP13766088.2
申请日：2013-09-24
发明人： WORTMANN, Lars , KLAR, Ulrich , KETTSCHAU, Georg , PÜHLER, Florian , LIENAU, Philip , PETERSEN, Kirstin , HÄGEBARTH, Andrea , SÜLZLE, Detlev , GRAHAM, Keith , RICHTER, Anja
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted indazol-pyrrolopyrimidinecompounds of general formula I: in which R
1a, R
1b , R
1c , R
1d , R
2a are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.摘要翻译： 本发明涉及通式I的取代的吲唑 - 吡咯并嘧啶化合物：其中R 1a，R 1b，R 1c，R 1d，R 2a如本文所述和定义，涉及制备所述化合物的方法，涉及用于制备 所述化合物，含有所述化合物的药物组合物和组合以及所述化合物在制备用于治疗或预防疾病，特别是过度增殖和/或血管生成障碍的药物组合物中的用途，或作为 与其他活性成分组合。
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公开(公告)号：EP3395818A1
公开(公告)日：2018-10-31
申请号：EP18167649.5
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje-Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib),
to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.-
公开(公告)号：EP2852596A1
公开(公告)日：2015-04-01
申请号：EP13725935.4
申请日：2013-05-17
发明人： KETTSCHAU, Georg , PÜHLER, Florian , EIS, Knut , KLAR, Ulrich , KOSEMUND, Dirk , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , BÖMER, Ulf , WORTMANN, Lars , GRAHAM, Keith , WENGNER, Antje Margret
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and /or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP2852593A1
公开(公告)日：2015-04-01
申请号：EP13723164.3
申请日：2013-05-17
发明人： KLAR, Ulrich , KETTSCHAU, Georg , SÜLZLE, Detlev , PÜHLER,Florian , KOSEMUND, Dirk , LIENAU, Philip , BÖMER, Ulf , WORTMANN, Lars
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P37/00
CPC分类号： C07D491/20 , A61K31/519 , A61K31/5377 , C07D487/04 , C07D487/14 , C07D487/16 , C07D495/14
摘要： The present invention relates to substituted pyrrolopyrimidine compounds general formula I : in which A, X, R
1 , R
2 , m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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