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公开(公告)号：EP3781565A1
公开(公告)日：2021-02-24
申请号：EP19720074.4
申请日：2019-04-15
发明人： WORTMANN, Lars , SAUTIER, Brice , EIS, Knut , BRIEM, Hans , BÖHNKE, Niels , VON NUSSBAUM, Franz , HILIG, Roman , BADER, Benjamin , SCHRÖDER, Jens , PETERSEN, Kirstin , LIENAU, Philip , WENGNER, Antje, Margret , MOOSMAYER, Dieter , WANG, Qiuwen
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
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公开(公告)号：EP3395818A1
公开(公告)日：2018-10-31
申请号：EP18167649.5
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje-Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib),
to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.-
公开(公告)号：EP3292107A1
公开(公告)日：2018-03-14
申请号：EP16721762.9
申请日：2016-05-02
发明人： EIS, Knut , ACKERSTAFF, Jens , WAGNER, Sarah , BUCHGRABER, Philipp , SÜLZLE, Detlev , HOLTON, Simon , BENDER, Eckhard , LI, Volkhart , LIU, Ningshu , SIEGEL, Franziska , LIENAU, Philip , BAIRLEIN, Michaela , VON NUSSBAUM, Franz , HERBERT,Simon , KOPPITZ, Marcus
IPC分类号： C07D233/54 , C07D263/34 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/14 , A61K31/38 , A61K31/4164 , A61K31/421 , A61K31/5025 , A61P35/00
CPC分类号： C07D233/90 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/454 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/554 , A61K45/06 , A61P35/00 , A61P35/04 , C07D233/54 , C07D263/34 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D487/04 , C07D487/10 , C07D487/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
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4.发明公开TRIAZOLO- UND TETRAZOLOPYRIMIDIN-DERIVATE ALS HNE-INHIBITOREN ZUR BEHANDLUNG VON COPD 有权三唑并与TETRAZOLOPYRIMIDIN衍生物作为HNE抑制剂用于COPD的治疗
公开(公告)号：EP2385945A1
公开(公告)日：2011-11-16
申请号：EP09796639.4
申请日：2009-12-29
发明人： VON NUSSBAUM, Franz , KARTHAUS, Dagmar , ANLAUF, Sonja , DELBECK, Martina , LI, Volkhart, Min-Jian , MEIBOM, Daniel , LUSTIG, Klemens
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D487/14
摘要： The invention relates to novel heterocyclic annulated diaryldihydro pyrimidine derivates, to a method for the production thereof, to the use thereof alone or in combination for treating and/or preventing illnesses, and to the use thereof for producing medications for treating and/or preventing illnesses, in particular for treating and/or preventing diseases of the lungs and cardiovascular system.
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公开(公告)号：EP3177619B1
公开(公告)日：2018-04-25
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3177619A1
公开(公告)日：2017-06-14
申请号：EP15744596.6
申请日：2015-08-03
发明人： WORTMANN, Lars , LÜCKING, Ulrich , LEFRANC, Julien , BRIEM, Hans , KOPPITZ, Marcus , EIS, Knut , VON NUSSBAUM, Franz , BADER, Benjamin , WENGNER, Antje Margret , SIEMEISTER, Gerhard , BONE, Wilhelm , LIENAU, Philip , GRUDZINSKA-GOEBEL, Joanna , MOOSMAYER, Dieter , EBERSPÄCHER, Uwe , SCHICK, Hans
IPC分类号： C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/541 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/04 , C07D491/22 , C07D519/00 , C07F9/6561
摘要： to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.
摘要翻译： 制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是过度增殖的药物组合物的所述化合物的用途 疾病作为唯一的药剂或与其他活性成分组合。
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7.发明公开SULFONAMID- UND SULFOXIMIN-SUBSTITUIERTE DIARYLDIHYDROPYRIMIDINONE UND IHRE VERWENDUNG 有权磺酰胺和亚砜取代DIARYLDIHYDROPYRIMIDINONE及其用途
公开(公告)号：EP2417112A1
公开(公告)日：2012-02-15
申请号：EP10713311.8
申请日：2010-03-30
发明人： VON NUSSBAUM, Franz , KARTHAUS, Dagmar , ANLAUF, Sonja , DELBECK, Martina , LI, Volkhart, Min-Jian , MEIBOM, Daniel , LUSTIG, Klemens , SCHNEIDER, Dirk
IPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61P11/08 , A61P9/10
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04
摘要： The present application relates to new sulfonic amide or sulfoximine-substituted 1.4-diaryl-dihydropyrimidine-2-on-derivatives, methods for the production thereof, the use thereof individually or in combination for treatment and/or prevention of diseases as well as the use thereof for production of drugs for treatment and/or prevention of diseases, in particular for treatment and/or prevention of pulmonary and cardiovascular diseases.
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8.发明授权4- (4-CYANO-2-THIOARYL) -DIHYDROPYRIMIDINONE UND IHRE VERWENDUNG 有权4-（4-氰基-2-硫代芳基）-DIHYDROPYRIMIDINONE及其用途
公开(公告)号：EP2234985B1
公开(公告)日：2012-03-07
申请号：EP08864824.1
申请日：2008-12-09
发明人： VON NUSSBAUM, Franz , KARTHAUS, Dagmar , ANLAUF, Sonja , DELBECK, Martina , LI, Volkhart Min-Jian , MEIBOM, Daniel , LUSTIG, Klemens , SCHAMBERGER, Jens
IPC分类号： C07D239/22 , A61K31/505 , A61P11/00
CPC分类号： C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present application relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of disorders, and to the use thereof for production of medicaments for treatment and/or prevention of disorders, especially for treatment and/or prevention of disorders of the lung and of the cardiovascular system.
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公开(公告)号：EP3601267A1
公开(公告)日：2020-02-05
申请号：EP18717840.5
申请日：2018-03-19
发明人： WORTMANN, Lars , SAUTIER, Brice , EIS, Knut , BRIEM, Hans , BÖHNKE, Niels , VON NUSSBAUM, Franz , HILLIG, Roman , BADER, Benjamin , SCHRÖDER, Jens , PETERSEN, Kirstin , LIENAU, Philip , WENGNER, Antje, Margret , MOOSMAYER, Dieter , WANG, Qiuwen , SCHICK, Hans
IPC分类号： C07D403/12 , C07D405/14 , C07D401/12 , C07D403/04 , C07D405/10 , C07D405/12 , C07D409/12 , C07D409/14 , C07D239/94 , C07D417/12 , C07D487/04 , C07D495/04 , A61P35/00 , A61K31/517
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公开(公告)号：EP3390401A1
公开(公告)日：2018-10-24
申请号：EP16822386.5
申请日：2016-12-12
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , SIEMEISTER, Gerhard , MÖNNING, Ursula , VON NUSSBAUM, Franz
IPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , A61K31/35 , A61K31/382 , A61K31/407 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
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