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    6-HYDROXYBENZOFURANYL- AND 6-ALKOXYBENZOFURANYL-SUBSTITUTED IMIDAZOPYRIDAZINES
    3.
    发明公开
    6-HYDROXYBENZOFURANYL- AND 6-ALKOXYBENZOFURANYL-SUBSTITUTED IMIDAZOPYRIDAZINES 审中-公开
    6-羟基苯并呋喃-2-基和6-烷氧基苯并呋喃基取代的咪唑并哒嗪

    公开(公告)号：EP3237417A1

    公开(公告)日：2017-11-01

    申请号：EP15817825.1

    申请日：2015-12-21

    申请人： Bayer Pharma Aktiengesellschaft

    发明人： EIS, Knut ,  HARTUNG, Ingo ,  PETERSEN, Kirstin ,  LIENAU, Philip ,  BÖMER, Ulf

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00 ,  A61P37/00

    CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06

    摘要： The present invention relates to 6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl- substituted imidazopyridazine compounds of general formula (I) in which R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的6-羟基苯并呋喃基和6-烷氧基苯并呋喃基取代的咪唑并哒嗪化合物，其中R 1和R 2如权利要求中所定义，涉及制备所述化合物的方法，涉及用于制备所述化合物的中间体化合物 ，涉及包含所述化合物的药物组合物和组合以及涉及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖和/或血管生成失调的药物组合物作为唯一药物或组合 与其他有效成分。

    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES
    4.
    发明公开
    AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES 有权
    氨基磺酰胺咪唑吡嗪

    公开(公告)号：EP2834245A1

    公开(公告)日：2015-02-11

    申请号：EP13712784.1

    申请日：2013-03-27

    申请人： Bayer Pharma Aktiengesellschaft

    发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHULZE, Volker ,  SÜLZLE, Detlev ,  LIENAU, Philip ,  HÄGEBARTH, Andrea ,  PETERSEN, Kirstin ,  BÖMER, Ulf

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00

    CPC分类号： C07D405/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/04

    摘要： The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I); in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的氨基取代的咪唑并哒嗪化合物。 其中A，R 1，R 2，R 3，R 4，R 5和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合， 的所述化合物用于制造用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合。