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公开(公告)号：EP3464248A1
公开(公告)日：2019-04-10
申请号：EP17724833.3
申请日：2017-05-23
发明人： SCHMEES, Norbert , GUTCHER, Ilona , IRLBACHER, Horst , BADER, Benjamin , ZHAO, Na , PLATTEN, Michael , ROEHN, Ulrike , ZORN, Ludwig , ROESE, Lars , STOECKIGT, Detlef
IPC分类号： C07D237/16 , C07D237/20 , C07D403/12 , C07D405/12 , A61P35/00 , A61K31/501
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公开(公告)号：EP3580211A1
公开(公告)日：2019-12-18
申请号：EP18703958.1
申请日：2018-02-02
发明人： GUTCHER, Ilona , RÖHN, Ulrike , SCHMEES, Norbert , ZORN, Ludwig , RÖSE, Lars , BADER, Benjamin , KOBER, Christina , CARRETERO, Rafael , STÖCKIGT, Detlef , IRLBACHER, Horst , PLATTEN, Michael
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D237/04 , C07D237/24 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/501 , A61P35/00
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3.发明公开3-NITROGEN OR SULPHUR SUBSTITUTED OESTRA-1,3,5(10),16-TETRAENE AKR1C3 INHIBITORS 审中-公开3-氮或硫取代的杂环-1,3,5（10），16-四烯AKR1C3抑制剂
公开(公告)号：EP3194419A1
公开(公告)日：2017-07-26
申请号：EP15771043.5
申请日：2015-09-07
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06 , C07J31/003 , C07J41/0038
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
摘要翻译： 本发明涉及式（I）的AKR1C3抑制剂及其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，尤其是 出血性疾病和子宫内膜异位症。
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公开(公告)号：EP3558972A1
公开(公告)日：2019-10-30
申请号：EP17832944.7
申请日：2017-12-18
发明人： BÄURLE, Stefan , DAVENPORT, Adam, James , STIMSON, Christopher , CARR, James, Lindsay , BUBERT, Christian, , MARLIN, Frédéric, Jacques , NAGEL, Jens , SCHMIDT, Nicole , ROTGERI, Andrea , IRLBACHER, Horst
IPC分类号： C07D401/14 , C07D401/10 , C07D403/10 , C07D257/04 , A61K31/41 , A61P29/00
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公开(公告)号：EP3194419B1
公开(公告)日：2018-09-05
申请号：EP15771043.5
申请日：2015-09-07
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06 , C07J31/003 , C07J41/0038
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
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6.发明公开NEUE INDAZOLCARBOXAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE DIE DIESE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权新INDAZOLCARBOXAMIDE，用于生产药物制剂含它们，它们在药品生产
公开(公告)号：EP3083586A1
公开(公告)日：2016-10-26
申请号：EP14824414.8
申请日：2014-12-16
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , ROTGERI, Andrea , BÖMER, Ulf , RING, Sven , IRLBACHER, Horst , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , SCHÄFER, Martina
IPC分类号： C07D401/12 , C07D401/14 , C07D417/12 , C07D409/12 , A61K31/4439 , A61K31/444 , A61P37/00 , A61P29/00
CPC分类号： C07D495/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/10 , C07D491/107
摘要： The invention relates to a novel 6-substituted indazoles with carboxamide side chains, method for the production thereof, to the use thereof alone or in combinations for treating and/or the prophylaxis of diseases and to the use thereof for producing medicaments for treating and/or the prophylaxis of diseases, in particular for treating and/or the prophylaxis of endometriosis, preventing lymphomas, macular degeneration, COPD and psoriasis.
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公开(公告)号：EP3580211B1
公开(公告)日：2020-12-02
申请号：EP18703958.1
申请日：2018-02-02
发明人： GUTCHER, Ilona , RÖHN, Ulrike , SCHMEES, Norbert , ZORN, Ludwig , RÖSE, Lars , BADER, Benjamin , KOBER, Christina , CARRETERO, Rafael , STÖCKIGT, Detlef , IRLBACHER, Horst , PLATTEN, Michael
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D237/04 , C07D237/24 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/501 , A61P35/00
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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9.发明公开SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF 审中-公开取代的吡啶基 - 环烷基 - 羧酸，含有它们的组合物及其医疗用途
公开(公告)号：EP3233802A1
公开(公告)日：2017-10-25
申请号：EP15810650.0
申请日：2015-12-16
发明人： BRÄUER, Nico , NAGEL, Jens , IRLBACHER, Horst , ROTGERI, Andrea , SCHWEDE, Wolfgang , DAHLLÖF, Henrik , KOPPITZ, Marcus , PETERS, Michaele , GODINHO-COELHO, Anne-Marie
IPC分类号： C07D213/84 , C07D405/12 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , A61K31/4418 , A61P1/00 , A61P15/00 , A61P29/00
CPC分类号： A61K31/167 , A61K31/44 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/84 , C07D405/12
摘要： The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
摘要翻译： 本发明涉及通式（I）的取代的吡啶基 - 环烷基 - 羧酸，涉及包含所述化合物的药物组合物和组合以及涉及所述化合物在制备用于治疗或预防疾病的药物组合物中的用途，特别是 在哺乳动物中，例如与疼痛相关的疾病，或用于治疗或预防疼痛综合征（急性和慢性），炎性诱导疼痛，骨盆疼痛，癌症相关疼痛，子宫内膜异位症相关疼痛以及子宫内膜异位症和子宫腺肌病等 ，癌症本身以及像子宫内膜异位症那样的增殖性疾病。
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10.发明公开SUSTITUTED ( HETEROARYLMETHYL ) THIOHYDANTOINS AS ANTICANCER DRUGS 审中-公开取代的（杂芳）-THIOHYDANTOINE作为抗癌剂
公开(公告)号：EP2475653A1
公开(公告)日：2012-07-18
申请号：EP10747836.4
申请日：2010-08-28
发明人： LÜCKING, Ulrich , CLEVE, Arwed , HAENDLER, Bernard , FAUS GIMENEZ, Hortensia , KÖHR, Silke , IRLBACHER, Horst
IPC分类号： C07D401/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D401/06 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
摘要： The invention relates to substituted (heteroarylmethyl) thiohydantoin compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, and their use for the preparation of medicaments for the treatment and/or prophylaxis of disorders, in particular of prostate cancer.
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