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1.发明授权INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 有权INHIBITING p38激酶活性THROUGH芳基 - 和杂芳基脲类的使用
公开(公告)号：EP1043995B9
公开(公告)日：2008-10-08
申请号：EP98964708.6
申请日：1998-12-22
发明人： DUMAS, Jacques , KHIRE, Uday , LOWINGER, Timothy, Bruno , RIEDL, Bernd , SCOTT, William, J. , SMITH, Roger, A. , WOOD, Jill, E. , HATOUM-MOKDAD, Holia , JOHNSON, Jeffrey , REDMAN, Aniko , SIBLEY, Robert
IPC分类号： A61K31/38 , A61K31/415 , A61K31/44
CPC分类号： A61K31/415 , A61K31/00 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
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2.发明授权
公开(公告)号：EP1042305B1
公开(公告)日：2005-06-08
申请号：EP98964221.0
申请日：1998-12-22
发明人： MILLER, Scott , OSTERHOUT, Martin , DUMAS, Jacques , KHIRE, Uday , LOWINGER, Timothy, Bruno , RIEDL, Bernd , SCOTT, William, J. , SMITH, Roger, A. , WOOD, Jill, E. , GUNN, David , HATOUM-MOKDAD, Holia , RODRIGUEZ, Mareli , SIBLEY, Robert , WANG, Ming , TURNER, Tiffany , BRENNAN, Catherine
IPC分类号： C07D273/00 , C07D275/00 , A61K31/17 , C07D333/20 , C07D233/70 , C07D213/70 , C07D209/88 , C07C317/42 , C07C275/36 , C07C205/57 , A61K31/44 , A61K31/535 , A61K31/425 , A61K31/40 , C07D207/26 , C07D207/40 , C07D213/53 , C07D231/08 , C07D277/68 , C07D209/76 , C07D213/68 , C07D233/22 , C07D307/20 , C07C275/34 , C07C311/48
CPC分类号： C07D207/27 , A61K31/17 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4436 , A61K31/4439 , A61K31/535 , A61K31/5375 , C07C205/11 , C07C205/22 , C07C205/37 , C07C205/38 , C07C205/57 , C07C205/58 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07C275/42 , C07C309/88 , C07C311/48 , C07C317/42 , C07D207/26 , C07D207/404 , C07D209/76 , C07D209/86 , C07D209/88 , C07D213/40 , C07D213/53 , C07D213/68 , C07D213/70 , C07D231/08 , C07D233/22 , C07D233/70 , C07D263/58 , C07D277/68 , C07D295/185 , C07D307/20 , C07D333/20 , C07D409/12 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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3.发明授权-G(V)-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 有权-G（V）-CARBOXYARYL取代的二苯脲作为RAF激酶抑制剂
公开(公告)号：EP1140840B1
公开(公告)日：2006-03-22
申请号：EP00903239.2
申请日：2000-01-12
发明人： RIEDL, Bernd , DUMAS, Jacques , KHIRE, Uday , LOWINGER, Timothy, B. , SCOTT, William, J. , SMITH, Roger, A. , WOOD, Jill, E. , MONAHAN, Mary-Katherine , NATERO, Reina , RENICK, Joel , SIBLEY, Robert, N.
IPC分类号： C07D211/78 , C07D211/72 , A61K31/33 , A61K31/54 , A61K31/535 , A61K31/17 , C07C275/20 , C07C275/22 , C07C275/24 , C07C275/28
CPC分类号： C07D295/192 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D209/50 , C07D213/75 , C07D213/80 , C07D213/81 , C07D295/073 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D401/12 , C07F7/1852 , C07F7/1856
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
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公开(公告)号：EP1047418B1
公开(公告)日：2005-07-27
申请号：EP98965981.8
申请日：1998-12-22
发明人： DUMAS, Jacques , KHIRE, Uday , LOWINGER, Timothy, Bruno , PAULSEN, Holger , RIEDL, Bernd , SCOTT, William, J. , SMITH, Roger, A. , WOOD, Jill, E. , HATOUM-MOKDAD, Holia , JOHNSON, Jeffrey , LEE, Wendy , REDMAN, Aniko , SIBLEY, Robert , RENICK, Joel
IPC分类号： A61K31/425 , A61K31/44 , A61K31/47 , C07D215/20 , C07D231/40 , C07D413/12 , C07D261/14 , C07D417/12 , C07D401/12 , C07D285/135 , C07D333/36 , C07D409/12
CPC分类号： C07D271/113 , C07D231/12 , C07D231/40 , C07D233/56 , C07D249/08 , C07D257/06 , C07D261/14 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
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5.发明授权INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 有权INHIBITING p38激酶活性THROUGH芳基 - 和杂芳基脲类的使用
公开(公告)号：EP1043995B1
公开(公告)日：2006-11-29
申请号：EP98964708.6
申请日：1998-12-22
发明人： DUMAS, Jacques , KHIRE, Uday , LOWINGER, Timothy, Bruno , RIEDL, Bernd , SCOTT, William, J. , SMITH, Roger, A. , WOOD, Jill, E. , HATOUM-MOKDAD, Holia , JOHNSON, Jeffrey , REDMAN, Aniko , SIBLEY, Robert
IPC分类号： A61K31/38 , A61K31/415 , A61K31/44
CPC分类号： A61K31/415 , A61K31/00 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
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6.发明授权INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 有权RAF激酶的抑制使用芳基 - 和杂芳基的杂环脲类
公开(公告)号：EP1056725B1
公开(公告)日：2006-06-07
申请号：EP98963810.1
申请日：1998-12-22
发明人： DUMAS, Jacques , KHIRE, Uday , LOWINGER, Timothy, Bruno , RIEDL, Bernd , SCOTT, William, J. , SMITH, Roger, A. , WOOD, Jill, E. , HATOUM-MOKDAD, Holia , JOHNSON, Jeffrey , REDMAN, Aniko , SIBLEY, Robert
IPC分类号： C07D231/38 , C07D403/12 , C07D409/12 , C07D333/36 , C07D307/66 , C07D231/40 , C07D401/12 , C07D405/04 , A61K31/415
CPC分类号： C07D401/12 , C07D231/40 , C07D333/36 , C07D401/14 , C07D405/04
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
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