-
1.发明授权MAKROCYCLISCHE METALLKOMPLEXE UND DEREN VERWENDUNG ZUR HERSTELLUNG VON KONJUGATEN MIT BIOMOLEKÜLEN 有权大环金属配合物和它们在偶联物与生物分子生产
公开(公告)号：EP1409024B1
公开(公告)日：2008-08-06
申请号：EP02754904.7
申请日：2002-07-18
发明人： PLATZEK, Johannes , SCHMITT-WILLICH, Heribert , MICHL, Günther , FRENZEL, Thomas , SÜLZLE, Detlev , BAUER, Hans , RADÜCHEL, Bernd , WEINMANN, Hanns-Joachim , SCHIRMER, Heiko
IPC分类号： A61K47/48 , A61K49/00 , C07D257/02 , C07F5/00
CPC分类号： A61K49/10 , A61K47/54 , A61K47/547 , A61K49/0002 , A61K49/085 , A61K49/14 , A61K49/143 , C07D257/02
摘要： The invention relates to macrocyclic metal complexes and production and use thereof for production of conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR and radio diagnostics and for radiotherapy. According to the invention, a high relaxivity and a fine-tuning of the relaxivity may be achieved by means of a special ligand formation with the macrocycles.
-
2.发明授权
公开(公告)号：EP1282610B1
公开(公告)日：2007-07-25
申请号：EP01929561.7
申请日：2001-04-12
发明人： REHWINKEL, Hartmut , HÖLSCHER, Peter , JAROCH, Stefan , SÜLZLE, Detlev , HILLMANN, Margrit , BURTON, Gerardine, Anne , MCDONALD, Fiona, Mcdougall
IPC分类号： C07D265/36 , C07D265/34 , A61K31/538
CPC分类号： C07D265/36 , C07D265/34
摘要： The invention relates to the compounds of formula (I), to the tautomers and isomers and salts thereof, and to a method for producing the same as well as to the use thereof in medicaments.
-
3.发明公开NEUE [F-18]-MARKIERTE L-GLUTAMINSÄURE- UND L-GLUTAMINDERIVATE (I), IHRE VERWENDUNG SOWIE VERFAHREN ZU IHRER HERSTELLUNG 审中-公开NEW [F-18]一种用于制备标记的L-谷氨酸和L-谷氨酰胺（I）的用途和方法
公开(公告)号：EP2282982A1
公开(公告)日：2011-02-16
申请号：EP09749581.6
申请日：2009-05-14
发明人： DINKELBORG, Ludger , BERNDT, Mathias , FRIEBE, Matthias , SCHMITT-WILLICH, Heribert , SÜLZLE, Detlev , KOGLIN, Norman
IPC分类号： C07B59/00 , C07C229/24 , C07C237/06 , A61K51/04 , A61K31/04 , A61K31/195
CPC分类号： A61K49/0433 , A61K51/0402 , C07B59/001 , C07C227/16 , C07C229/24 , C07C231/12 , C07C237/06 , C07C269/06 , C07C271/22 , C07C309/66 , C07D207/16 , C07D207/28
摘要： The invention relates to compounds and the synthesis of [F-18] labelled L-glutamic acid, [F-18] labelled L-glutamate, to their derivatives according to formula (I) and to their uses.
-
4.发明公开KONJUGATE VON HYDROXYPYRIDINONDERIVAT-METALLKOMPLEXEN MIT BIOMOLEKÜLEN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON MITTELN FÜR DIE NMR-DIAGNOSTIK 审中-公开HYDROXYPYRIDINONDERIVAT金属络合物与生物分子和它们在资金，用于核磁共振诊断生产结合物
公开(公告)号：EP1856046A1
公开(公告)日：2007-11-21
申请号：EP05817920.1
申请日：2005-12-20
发明人： MISSELWITZ, Bernd , SÜLZLE, Detlev , BRUMBY, Thomas , JACQUES, Vincent , DUMAS, Stephane , PLATZEK, Johannes , SCHIRMER, Heiko , SCHMITT-WILLICH, Heribert
IPC分类号： C07D211/22 , C07D239/22 , C07C65/01 , A61K31/4412 , A61K31/513 , A61K31/60
CPC分类号： C07D213/81 , A61K47/643 , C07D239/52 , C07D401/12 , C07D403/12
摘要： The invention relates to conjugates of metal complex hydroxypyridin derivatives and biomolecules and to the production thereof. Said conjugates are suitable for use in the form of contrast agents in NMR diagnosis. The special embodiment of ligands makes it possible to obtain a high relaxivity and to increase a NMDR maximum.
-
5.发明公开HYDROXYPYRIDINON-DERIVATE, DEREN METALLKOMPLEXE UND DEREN VERWENDUNG ZUR HERSTELLUNG VON KONJUGATEN MIT BIOMOLEK]LEN 审中-公开羟基吡啶衍生物，它们的金属配合物和它们在偶联物与生物分子制作] LEN
公开(公告)号：EP1828129A1
公开(公告)日：2007-09-05
申请号：EP05818828.5
申请日：2005-12-20
发明人： SCHMITT-WILLICH, Heribert , SCHIRMER, Heiko , PLATZEK, Johannes , DUMAS, Stephane , JACQUES, Vincent , BRUMBY, Thomas , SÜLZLE, Detlev , MISSELWITZ, Bernd
IPC分类号： C07D211/86 , A61K49/10
CPC分类号： C07D239/52 , A61K49/085 , A61K49/10 , C07C235/60 , C07D213/81 , C07D401/14
摘要： The invention relates to hydroxypyridinone derivatives, their metal complexes and their use in the production of conjugates with biomolecules. The inventive conjugates are suitable as contrast media in NMR diagnostics. A specific configuration of the ligands allows to obtain a high relaxation and to increase the NMRD maximum.
-
-
-
-
搜索结果
5 条记录 (耗时 0.019 秒)
