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1.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472A1
公开(公告)日：2011-03-30
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
2.发明公开
公开(公告)号：EP3589606A1
公开(公告)日：2020-01-08
申请号：EP18708368.8
申请日：2018-02-22
发明人： VOLCHKOV, Ivan, N. , REEVES, Jonathan, Timothy , DANG, Mai, Thi, Quynh , HAMPEL, Thomas, Armin , KOCH, Sandra , NORDSTROM, Fredrik, Lars , REICHEL, Carsten , SCHOERER, Marvin , STANGE, Christian , ZHONG, Li , ZIMMERMANN, Uwe, Johannes
IPC分类号： C07B37/06 , C07D209/48
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公开(公告)号：EP2847177B1
公开(公告)日：2017-10-11
申请号：EP13724059.4
申请日：2013-05-01
IPC分类号： C07D305/06 , C07C213/02 , C07C215/10 , C07C227/10 , C07C229/24
CPC分类号： C07D305/06 , C07C213/00 , C07C215/10 , C07C215/28 , C07C227/10 , C07C229/24 , C07C229/34
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4.发明公开STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS 审中-公开某些TRIFLUORMETHYLSUBSTITUIERTER醇的立体选择性合成
公开(公告)号：EP2438040A2
公开(公告)日：2012-04-11
申请号：EP10721252.4
申请日：2010-05-28
IPC分类号： C07C231/18
CPC分类号： C07C231/18 , C07B2200/07 , C07C235/42
摘要： A process for stereoselective synthesis of a compound of Formula (X) or Formula (X') wherein R
1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R
1 is independently C
1 -C
5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R
1 is optionally independently substituted with one to three substituents selected from C
1 -C
3 alkyl, C
1 -C
3 alkoxy, phenyl, and alkoxyphenyl; and R
2 and R
3 are each independently C
1 -C
5 alkyl.-
5.发明公开
公开(公告)号：EP2847177A1
公开(公告)日：2015-03-18
申请号：EP13724059.4
申请日：2013-05-01
IPC分类号： C07D305/06 , C07C213/02 , C07C215/10 , C07C227/10 , C07C229/24
CPC分类号： C07D305/06 , C07C213/00 , C07C215/10 , C07C215/28 , C07C227/10 , C07C229/24 , C07C229/34
摘要： This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions amenable for large-scale commercial production.
摘要翻译： 本发明涉及制备具有式（I）的氧杂环丁烷-3-基甲胺的方法， 和R2？ 如本文所定义。 本发明的方法以高产率和适于大规模商业生产的条件提供式（I）化合物。
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6.发明授权
公开(公告)号：EP2280974B1
公开(公告)日：2012-01-25
申请号：EP09739539.6
申请日：2009-04-28
CPC分类号： C07B57/00 , C07D487/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and R
5 are as described herein.-
7.发明授权GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472B1
公开(公告)日：2012-01-18
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
8.发明公开
公开(公告)号：EP2280974A1
公开(公告)日：2011-02-09
申请号：EP09739539.6
申请日：2009-04-28
CPC分类号： C07B57/00 , C07D487/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and R
5 are as described herein.
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