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公开(公告)号：EP1718608A1
公开(公告)日：2006-11-08
申请号：EP05714457.8
申请日：2005-02-18
发明人： TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
IPC分类号： C07D201/00
CPC分类号： C07D487/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.
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公开(公告)号：EP1718608B1
公开(公告)日：2013-07-17
申请号：EP05714457.8
申请日：2005-02-18
发明人： TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
IPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12
CPC分类号： C07D487/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
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公开(公告)号：EP1587787A1
公开(公告)日：2005-10-26
申请号：EP04703130.7
申请日：2004-01-19
发明人： BEAULIEU, Pierre Louis , BROCHU, Christian , CHABOT, Catherine , JOLICOEUR, Eric , KAWAI, Stephen , POUPART, Marc-André , TSANTRIZOS, Youla S.
IPC分类号： C07D209/08 , C07D405/04 , C07D405/14 , C07D401/06 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , C07D401/04 , C07D413/14 , C07D513/04 , C07D209/30 , A61K31/404 , A61P31/12
CPC分类号： C07D401/04 , C07D209/08 , C07D209/30 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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