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1.发明授权
公开(公告)号：EP1071670B1
公开(公告)日：2004-07-07
申请号：EP99920661.8
申请日：1999-04-14
发明人： BRENNER, Michael , BECHTEL, Wolf-Dietrich , PALLUK, Rainer , WIENRICH, Marion , WEISER, Thomas , CEREDA, Enzo , BIGNOTTI, Maura , PELLEGRINI, Carlomaria
IPC分类号： C07D249/08 , C07D263/32 , C07D263/38 , C07D233/54 , C07D233/70 , C07D233/78 , C07D271/10 , C07D207/32 , C07D207/44 , C07D231/22
CPC分类号： C07D207/333 , C07D231/12 , C07D231/22 , C07D233/64 , C07D249/08 , C07D261/08 , C07D263/32
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2.发明授权
公开(公告)号：EP1077950B1
公开(公告)日：2004-09-22
申请号：EP99920662.6
申请日：1999-04-14
发明人： BRENNER, Michael , PALLUK, Rainer , WIENRICH, Marion , WEISER, Thomas , CEREDA, Enzo , BIGNOTTI, Maura , PELLEGRINI, Carlo Maria , SCHIAVI, Giovanni, Battista , CESANA, Raffaele
IPC分类号： C07D239/26 , C07D239/36 , C07D251/22 , C07D253/06 , A61K31/505 , A61K31/53
CPC分类号： C07D239/26 , C07D239/36 , C07D251/16 , C07D253/065
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3.发明公开NEW N, N'-DISUBSTITUTED BENZIMIDAZOLONE DERIVATIVES WITH AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS 有权NEW N，N'-二取代的具有亲和力的血清素和多巴胺受体的苯并咪唑衍生物
公开(公告)号：EP1322622A2
公开(公告)日：2003-07-02
申请号：EP01985252.4
申请日：2001-09-08
发明人： CEREDA, Enzo , MAIOCCHI, Luciano , BRAMBILLA, Alessandro , GIRALDO, Ettore , MONFERINI, Eugenia , SCHIAVI, Giovanni, Battista
IPC分类号： C07D235/26 , A61K31/4184 , A61P43/00 , C07D401/12 , C07D403/12 , C07D471/04 , C07D401/14 , C07D401/06 , C07D471/10 , C07D405/12
CPC分类号： C07D401/06 , C07D235/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D471/10
摘要： The present invention relates to novel pharmacologically active N, N'-disubstituted benzimidazolone derivatives of general formula (I) where R?1, R2, R3¿, and A are as defined in specification and claims, their pharmaceutically acceptable salts, to their preparation and their use for therapeutic purposes.
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4.发明授权NEW BENZIMIDAZOLONE DERIVATIVES DISPLAYING AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS 有权具有亲和力多巴胺苯并咪唑酮衍生物受体的血清素和
公开(公告)号：EP1322621B1
公开(公告)日：2006-10-04
申请号：EP01974239.4
申请日：2001-09-11
发明人： CEREDA, Enzo , MAIOCCHI, Luciano , BRAMBILLA, Alessandro , GIRALDO, Ettore , SCHIAVI, Giovanni, Battista
IPC分类号： C07D235/26 , C07D401/12 , C07D471/04 , C07D403/12 , C07D401/14 , C07D405/12 , C07D471/10 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/506 , A61K31/437 , A61K31/438 , A61P25/22
CPC分类号： C07D401/12 , C07D235/26 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D471/10
摘要： N, N'-Disubtituted benzimidazolone derivatives of general formula (I) wherein R1 is hydrogen, alkyl or cycloaljylalkyl, A is alkenylene and R?2 and R3¿ together with N form sepecified cyclic system are serotonine or dopamine receptor ligands useful in the treatment of anxiety and affective disorders.
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5.发明公开NEW BENZIMIDAZOLONE DERIVATIVES DISPLAYING AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS 有权具有亲和力多巴胺苯并咪唑酮衍生物受体的血清素和
公开(公告)号：EP1322621A1
公开(公告)日：2003-07-02
申请号：EP01974239.4
申请日：2001-09-11
发明人： CEREDA, Enzo , MAIOCCHI, Luciano , BRAMBILLA, Alessandro , GIRALDO, Ettore , SCHIAVI, Giovanni, Battista
IPC分类号： C07D235/26 , C07D401/12 , C07D471/04 , C07D403/12 , C07D401/14 , C07D405/12 , C07D471/10 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/506 , A61K31/437 , A61K31/438 , A61P25/22
CPC分类号： C07D401/12 , C07D235/26 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D471/10
摘要： N, N'-Disubtituted benzimidazolone derivatives of general formula (I) wherein R1 is hydrogen, alkyl or cycloaljylalkyl, A is alkenylene and R?2 and R3¿ together with N form sepecified cyclic system are serotonine or dopamine receptor ligands useful in the treatment of anxiety and affective disorders.
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6.发明公开NEW POLYMERS BASED ON N-CARBAMYL-N'-DIMETHYLSILYL METHYL-PIPERAZINE TRACELESS LINKERS FOR THE SOLID PHASE SYNTHESIS OF PHENYL BASED LIBRARIES 审中-公开基于用于PHENYLSUBSTANZBIBLIOTHEKEN的固相合成N-氨基甲酰基甲基-N'-二甲基甲硅烷甲基哌嗪残留游离的接头POLYMERS
公开(公告)号：EP1360211A2
公开(公告)日：2003-11-12
申请号：EP02703549.2
申请日：2002-01-15
CPC分类号： C40B80/00 , C08F8/42 , C08G65/329 , C08G65/3331 , C08G65/336 , C40B50/18
摘要： The present invention relates to polymers characterised by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in their structure.
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7.发明公开BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY 有权具有亲和力对于这两种血清素和多巴胺受体苯并咪唑酮衍生物
公开(公告)号：EP1218352A1
公开(公告)日：2002-07-03
申请号：EP00965975.6
申请日：2000-09-12
IPC分类号： C07D235/26
CPC分类号： C07D235/26
摘要： The present invention pertains to compounds of general formula (I) wherein R1, R2, R3, and R4 denote hydrogen or hydroxy with the proviso that R1, R2, R3, and R4 cannot simultaneously represent hydrogen. These compounds bind to the Serotonine and dopamine receptors and are useful in the treatment of CNS disorders.
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8.发明公开
公开(公告)号：EP1077950A1
公开(公告)日：2001-02-28
申请号：EP99920662.6
申请日：1999-04-14
发明人： BRENNER, Michael , PALLUK, Rainer , WIENRICH, Marion , WEISER, Thomas , CEREDA, Enzo , BIGNOTTI, Maura , PELLEGRINI, Carlo, Maria , SCHIAVI, Giovanni, Battista , CESANA, Raffaele
IPC分类号： C07D239/26 , C07D239/36 , C07D251/22 , C07D253/06 , A61K31/505 , A61K31/53
CPC分类号： C07D239/26 , C07D239/36 , C07D251/16 , C07D253/065
摘要： The invention relates to novel diphenyl-substituted 6-ring-heterocycles of general formula (I), wherein A, X and the radicals R?1, R2, R3, R4 and R5¿ have the meanings given in the description. The invention also relates to methods for producing the inventive compounds and to their use as medicaments.
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9.发明公开DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT 4? ANTAGONISTIC ACTIVITY 失效二取代哌啶-1,4-酯和酰胺MIT 5-HT 4拮抗活性
公开(公告)号：EP0815080A1
公开(公告)日：1998-01-07
申请号：EP96907342.0
申请日：1996-03-04
发明人： CEREDA, Enzo , BIGNOTTI, Maura , MARTINO, Vincenzo , SCHIAVI, Giovanni, Battista , SAGRADA, Angelo
CPC分类号： C07D401/12 , C07D211/26
摘要： Pharmacologically active novel esters and amides of di-substituted 1,4-piperidine as 5-HT4 antagonists of general formula (I), wherein A, X, Y and R have the meanings specified in the description, processes for their preparation and pharmaceutical compositions containing them, are disclosed.
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10.发明授权DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY 失效二取代哌啶-1,4-酯和酰胺MIT 5-HT 4拮抗活性
公开(公告)号：EP0815080B1
公开(公告)日：2004-06-16
申请号：EP96907342.8
申请日：1996-03-04
发明人： CEREDA, Enzo , BIGNOTTI, Maura , MARTINO, Vincenzo , SCHIAVI, Giovanni, Battista , SAGRADA, Angelo
IPC分类号： C07D211/22 , A61K31/445 , C07D211/26 , C07D401/12 , C07D401/06
CPC分类号： C07D401/12 , C07D211/26
摘要： Pharmacologically active novel esters and amides of di-substituted 1,4-piperidine as 5-HT4 antagonists of general formula (I), wherein A, X, Y and R have the meanings specified in the description, processes for their preparation and pharmaceutical compositions containing them, are disclosed.
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