公开(公告)号：EP1381598A1

公开(公告)日：2004-01-21

申请号：EP02723631.4

申请日：2002-03-26

申请人： Bristol-Myers Squibb Company

发明人： WITTMAN, Mark, D. ,  BALASUBRAMANIAN, Neelakantan ,  VELAPARTHI, Upender ,  ZIMMERMANN, Kurt ,  SAULNIER, Mark, G. ,  LIU, Peiying ,  SANG, Xiaopeng ,  FRENNESSON, David, B. ,  STOFFAN, Karen, M. ,  TARRANT, James, G.

IPC分类号： C07D401/14 ,  A61K31/4184

CPC分类号： C07D401/04 ,  A61K31/4184 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

摘要： The present invention provides compounds of formula I[ ] and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.

公开(公告)号：EP1545543A2

公开(公告)日：2005-06-29

申请号：EP03774510.6

申请日：2003-10-01

申请人： Bristol-Myers Squibb Company

发明人： WITTMAN, Mark, D. ,  BALASUBRAMANIAN, Neelakantan ,  VELAPARTHI, Upender ,  ZIMMERMANN, Kurt ,  SAULNIER, Mark, G. ,  LIU, Peiying ,  SANG, Xiaopeng ,  FRENNESSON, David, B. ,  STOFFAN, Karen, M. ,  TARRANT, James, G. ,  MARINIER, Anne ,  ROY, Stephan

IPC分类号： A61K31/5355 ,  C07D413/14

CPC分类号： C07D417/14 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.