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公开(公告)号：EP1381598A1
公开(公告)日：2004-01-21
申请号：EP02723631.4
申请日：2002-03-26
发明人： WITTMAN, Mark, D. , BALASUBRAMANIAN, Neelakantan , VELAPARTHI, Upender , ZIMMERMANN, Kurt , SAULNIER, Mark, G. , LIU, Peiying , SANG, Xiaopeng , FRENNESSON, David, B. , STOFFAN, Karen, M. , TARRANT, James, G.
IPC分类号： C07D401/14 , A61K31/4184
CPC分类号： C07D401/04 , A61K31/4184 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention provides compounds of formula I[ ] and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
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公开(公告)号：EP2872514B1
公开(公告)日：2017-08-30
申请号：EP13739922.6
申请日：2013-07-12
发明人： PURANDARE, Ashok Vinayak , FINK, Brian E. , JOHNSON, Walter Lewis , HART, Amy C. , HE, Liqi , HUYNH, Tram N. , INGHRIM, Jennifer , MASTALERZ, Harold , SANG, Xiaopeng , TARBY, Christine M. , WAN, Honghe , VACCARO, Wayne , ZHANG, Guifen , ZHAO, Yufen , ZIMMERMANN, Kurt , ZHANG, Yong , CHEN, Libing , CHEN, Bin , TOKARSKI, John S. , GAVAI, Ashvinikumar V.
IPC分类号： C07D487/04 , A61K31/53 , A61P17/08 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/65213 , C07F9/6561 , C07F9/65616
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公开(公告)号：EP2872514A1
公开(公告)日：2015-05-20
申请号：EP13739922.6
申请日：2013-07-12
发明人： PURANDARE, Ashok Vinayak , FINK, Brian E. , JOHNSON, Walter Lewis , HART, Amy C. , HE, Liqi , HUYNH, Tram N. , INGHRIM, Jennifer , MASTALERZ, Harold , SANG, Xiaopeng , TARBY, Christine M. , WAN, Honghe , VACCARO, Wayne , ZHANG, Guifen , ZHAO, Yufen , ZIMMERMANN, Kurt , ZHANG, Yong , CHEN, Libing , CHEN, Bin , TOKARSKI, John S. , GAVAI, Ashvinikumar V.
IPC分类号： C07D487/04 , A61K31/53 , A61P17/08 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/65213 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）的化合物及其药学上可接受的盐。 式（I）咪唑并三嗪抑制蛋白激酶活性，从而使它们可用作抗癌剂。
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公开(公告)号：EP2132203A1
公开(公告)日：2009-12-16
申请号：EP08745365.0
申请日：2008-04-09
发明人： MARINIER, Anne , DODIER, Marco , ROY, Stephan , ZIMMERMANN, Kurt , SANG, Xiaopeng , WITTMAN, Mark D. , LANGLEY, David R. , RAJAMANI, Ramkumar
IPC分类号： C07D417/14 , A61K31/4427
CPC分类号： C07D417/14
摘要： The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's disease.
摘要翻译： 本发明提供了式（I）的化合物及其药学上可接受的盐。 式I噻唑基化合物抑制酪氨酸激酶活性，从而使它们可用作抗癌剂并用于治疗阿尔茨海默氏病。
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公开(公告)号：EP2041138B1
公开(公告)日：2014-06-25
申请号：EP07799265.9
申请日：2007-07-03
发明人： MASTALERZ, Harold , WITTMAN, Mark D. , ZIMMERMANN, Kurt , SAULNIER, Mark G. , VELAPARTHI, Upender , VYAS, Dolatrai M. , ZHANG, Guifen , JOHNSON, Walter Lewis , FRENNESSON, David B. , SANG, Xiaopeng , LIU, Peiying , LANGLEY, David R.
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00 , A61P25/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
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公开(公告)号：EP2041138A2
公开(公告)日：2009-04-01
申请号：EP07799265.9
申请日：2007-07-03
发明人： MASTALERZ, Harold , WITTMAN, Mark D. , ZIMMERMANN, Kurt , SAULNIER, Mark G. , VELAPARTHI, Upender , VYAS, Dolatrai M. , ZHANG, Guifen , JOHNSON, Walter Lewis , FRENNESSON, David B. , SANG, Xiaopeng , LIU, Peiying , LANGLEY, David R.
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00 , A61P25/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供了式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们可用作抗癌剂并用于治疗阿尔茨海默氏病。
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公开(公告)号：EP1545543A2
公开(公告)日：2005-06-29
申请号：EP03774510.6
申请日：2003-10-01
发明人： WITTMAN, Mark, D. , BALASUBRAMANIAN, Neelakantan , VELAPARTHI, Upender , ZIMMERMANN, Kurt , SAULNIER, Mark, G. , LIU, Peiying , SANG, Xiaopeng , FRENNESSON, David, B. , STOFFAN, Karen, M. , TARRANT, James, G. , MARINIER, Anne , ROY, Stephan
IPC分类号： A61K31/5355 , C07D413/14
CPC分类号： C07D417/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
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