公开(公告)号：EP2909987A4

公开(公告)日：2016-07-13

申请号：EP13847242

申请日：2013-09-06

Applicant: CALIFORNIA INST OF TECHN

Inventor： CHANG CHIEH-FENG ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

IPC: H04L29/02 ,  G06K19/07 ,  H02J50/10 ,  H02J50/30 ,  H04B10/00

CPC classification number: H02J17/00 ,  A61B5/0017 ,  A61B5/0031 ,  A61B18/18 ,  A61B2560/0219 ,  A61N1/08 ,  G06K19/0707 ,  G06K19/0716 ,  G06K19/0717 ,  G06K19/07775 ,  H01L31/042 ,  H02J50/10 ,  H02J50/30

公开(公告)号：EP2809813A4

公开(公告)日：2016-06-01

申请号：EP13744261

申请日：2013-02-01

Applicant: CALIFORNIA INST OF TECHN

Inventor： KARTALOV EMIL P ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

IPC: C12Q1/68 ,  G01N21/64 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/20 ,  G06F19/24

CPC classification number: G06F19/20 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G01N21/6486 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/24 ,  C12Q2537/101 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/107

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：EP2446467A4

公开(公告)日：2014-07-02

申请号：EP10792619

申请日：2010-06-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： SCHERER AXEL ,  WALAVALKAR SAMEER ,  HENRY MICHAEL D ,  HOMYK ANDREW P

IPC: H01L21/336 ,  B82Y10/00 ,  H01L29/06 ,  H01L29/41 ,  H01L29/775

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  B82Y40/00 ,  H01L29/0676 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/66666 ,  H01L29/775 ,  H01L29/7827 ,  H01L33/18 ,  Y10S977/762

公开(公告)号：EP2904376A4

公开(公告)日：2016-07-20

申请号：EP13844221

申请日：2013-10-04

Applicant: CALIFORNIA INST OF TECHN

Inventor： WALAVALKAR SAMEER SUDHIR ,  HOMYK ANDREW PETER ,  JONES WILLIAM MAXWELL ,  SCHERER AXEL ,  FRASER SCOTT ,  TRUONG THAI VIET

IPC: G01N33/483 ,  G01N21/64

CPC classification number: G01N21/63 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/648

Abstract: Devices, systems, and methods for detection of an analyte in a sample are disclosed. In some embodiments, an optical sensor can include a metallic layer and a plurality of dielectric pillars extending through the metallic layer. A plurality of regions of concentrated light can be supported in proximity to the ends of the plurality of dielectric pillars when a surface of the metallic layer is illuminated. Concentrated light within one or more of these regions can interact with an analyte molecule, allowing for detection of the analyte.

Abstract translation: 公开了用于检测样品中分析物的装置，系统和方法。 在一些实施例中，光学传感器可以包括延伸穿过金属层的金属层和多个介电柱。 当金属层的表面被照亮时，多个集中的光的区域可以被支撑在多个介电柱的端部附近。 一个或多个这些区域内的浓缩光可与分析物分子相互作用，允许检测分析物。

公开(公告)号：EP2880420A4

公开(公告)日：2016-03-16

申请号：EP13825792

申请日：2013-07-22

Applicant: CALIFORNIA INST OF TECHN

Inventor： MALIK IMRAN R ,  MADERO XIOMARA L ,  GARCIA ERIKA F ,  SCHERER AXEL

IPC: G01N21/17 ,  G01N21/03 ,  G01N21/64

CPC classification number: G01N21/64 ,  G01N21/0303 ,  G01N21/645

公开(公告)号：EP2211656A4

公开(公告)日：2012-05-23

申请号：EP08857853

申请日：2008-11-28

Applicant: CALIFORNIA INST OF TECHN

Inventor： MALTEZOS GEORGE ,  SCHERER AXEL

IPC: A44C17/00 ,  A44C25/00 ,  A44C27/00 ,  B28D5/00 ,  G01N21/87 ,  G02B5/18

CPC classification number: A44C17/001 ,  G01N21/87

公开(公告)号：EP2948566A4

公开(公告)日：2016-10-05

申请号：EP14743745

申请日：2014-01-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  GOLDBERG MARK D ,  GARCIA ERIKA F ,  MADERO XIOMARA L ,  TOMBRELLO THOMAS A ,  SCHERER AXEL

IPC: C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

Abstract translation: 本公开提供了用于检测样品中多种分析物的方法，组合物和试剂盒。 在一些实例中，本公开提供了用于检测分析物，遗传变异，监测反应过程以及通过测量信号监测分析物 - 分析物相互作用的方法，组合物和试剂盒。 在一些示例中，信号的存在或信号的改变可用于构建可用于检测分析物的信号谱。

公开(公告)号：EP2882534A4

公开(公告)日：2016-04-13

申请号：EP13827651

申请日：2013-08-07

Applicant: CALIFORNIA INST OF TECHN

Inventor： GORMAN JOHN B ,  MALTEZOS GEORGE ,  SCHERER AXEL

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/1827 ,  B01L2300/1844

公开(公告)号：EP2782495A4

公开(公告)日：2015-08-05

申请号：EP12852242

申请日：2012-11-21

Applicant: CALIFORNIA INST OF TECHN

Inventor： SCHERER AXEL ,  NJOROGE SAMUEL ,  HUANG JINGQING

IPC: A61B5/00 ,  G01N21/41 ,  G01N33/53

CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

公开(公告)号：EP1386185A4

公开(公告)日：2004-08-18

申请号：EP02766884

申请日：2002-05-02

Applicant: CALIFORNIA INST OF TECHN

Inventor： SCHERER AXEL ,  VUCKOVIC JELENA ,  LONCAR MARKO ,  MABUCHI HIDEO

IPC: G02B6/12 ,  G02B1/02 ,  G02B5/20 ,  G02B6/122 ,  G02F1/365 ,  H01S5/10 ,  H01S5/12 ,  G02B6/10

CPC classification number: H01S5/10 ,  B82Y20/00 ,  G02B6/1225 ,  H01S5/105

Abstract: Optical microcavities (12) based on two dimensional arrays of holes (14,18) defined in photonic crystals (10) are optimized for maximum Q factors and minimum mode volume. They can also be used for strong coupling between the cavity field and an atom trapped within a defect of the photonic crystals (10), or for tunable filters if the holes are filled with electro-optical polymers. In one embodiment the Q factor of a cavity is increased by elongation of a plurality of holes in at least one row in a predetermined direction. Modal structures of microcavities, as well as quality factors, mode volumes, symmetry properties and radiation patterns of localized defect modes as a function of the slab thickness and parameters of photonic crystal (10) and defects are illustrated.

Abstract translation: 基于光子晶体（10）中定义的空穴（14,18）的二维阵列的光学微腔（12）针对最大Q因数和最小模式体积进行优化。 它们也可用于腔场与光子晶体缺陷内捕获的原子之间的强耦合，或者如果孔填充有电光聚合物，则用于可调谐滤波器。 在一个实施例中，腔体的Q因子通过在预定方向上的至少一排中的多个孔的伸长而增加。 举例说明了微腔的模态结构以及品质因数，模式体积，对称性和局部缺陷模式的辐射模式，作为光子晶体厚度和参数以及缺陷的函数。