公开(公告)号：EP2948566A4

公开(公告)日：2016-10-05

申请号：EP14743745

申请日：2014-01-23

Applicant: CALIFORNIA INST OF TECHN

Inventor： RAJAGOPAL ADITYA ,  GOLDBERG MARK D ,  GARCIA ERIKA F ,  MADERO XIOMARA L ,  TOMBRELLO THOMAS A ,  SCHERER AXEL

IPC: C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for detecting analytes, genetic variations, monitoring reaction process, and monitoring analyte-analyte interactions by measuring signals. In some examples, the presence of signals or changes in signals may be used to construct signal profiles which can be used to detect analytes.

Abstract translation: 本公开提供了用于检测样品中多种分析物的方法，组合物和试剂盒。 在一些实例中，本公开提供了用于检测分析物，遗传变异，监测反应过程以及通过测量信号监测分析物 - 分析物相互作用的方法，组合物和试剂盒。 在一些示例中，信号的存在或信号的改变可用于构建可用于检测分析物的信号谱。

公开(公告)号：EP2877845A4

公开(公告)日：2016-03-30

申请号：EP13822966

申请日：2013-07-12

Applicant: CALIFORNIA INST OF TECHN ,  SANOFI US

Inventor： RAJAGOPAL ADITYA ,  CHANG CHIEH-FENG ,  PLETTENBURG OLIVER ,  PETRY STEFAN ,  SCHERER AXEL ,  TSCHIRHART CHARLES L

IPC: G01N27/414 ,  B82B3/00 ,  B82Y15/00 ,  G01N33/50 ,  H01L29/06 ,  H01L29/41 ,  H01L29/45 ,  H01L29/49 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

CPC classification number: H01L29/413 ,  B82Y15/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0676 ,  H01L29/45 ,  H01L29/49 ,  H01L29/73 ,  H01L29/732 ,  H01L29/735 ,  H01L29/78

Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.

公开(公告)号：EP2467881A4

公开(公告)日：2014-12-24

申请号：EP10810692

申请日：2010-08-20

Applicant: CALIFORNIA INST OF TECHN

Inventor： SCHERER AXEL ,  RAJAGOPAL ADITYA ,  KIM SEHEON ,  HOMYK ANDREW P

IPC: H01L31/04 ,  A61B5/00 ,  G01J3/02 ,  H01L27/142 ,  H01L31/0352 ,  H01L31/052 ,  H01L31/053 ,  H03F3/08 ,  H03F3/45 ,  H04B10/80

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

公开(公告)号：EP2909987A4

公开(公告)日：2016-07-13

申请号：EP13847242

申请日：2013-09-06

Applicant: CALIFORNIA INST OF TECHN

Inventor： CHANG CHIEH-FENG ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

IPC: H04L29/02 ,  G06K19/07 ,  H02J50/10 ,  H02J50/30 ,  H04B10/00

CPC classification number: H02J17/00 ,  A61B5/0017 ,  A61B5/0031 ,  A61B18/18 ,  A61B2560/0219 ,  A61N1/08 ,  G06K19/0707 ,  G06K19/0716 ,  G06K19/0717 ,  G06K19/07775 ,  H01L31/042 ,  H02J50/10 ,  H02J50/30

公开(公告)号：EP2809813A4

公开(公告)日：2016-06-01

申请号：EP13744261

申请日：2013-02-01

Applicant: CALIFORNIA INST OF TECHN

Inventor： KARTALOV EMIL P ,  RAJAGOPAL ADITYA ,  SCHERER AXEL

IPC: C12Q1/68 ,  G01N21/64 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/20 ,  G06F19/24

CPC classification number: G06F19/20 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G01N21/6486 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/24 ,  C12Q2537/101 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/107

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：EP2689005A4

公开(公告)日：2014-09-03

申请号：EP12760549

申请日：2012-03-19

Applicant: CALIFORNIA INST OF TECHN

Inventor： WALKER CHRISTOPHER I ,  RAJAGOPAL ADITYA

IPC: C12M1/38 ,  B01L3/00 ,  B01L7/00 ,  C12M1/34 ,  C12Q1/68

CPC classification number: B01L3/502707 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1827