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1.发明公开DEVICES AND METHODS FOR ENRICHMENT AND ALTERATION OF CIRCULATING TUMOR CELLS AND OTHER PARTICLES 审中-公开器件和方法富集与蚀变与另一个粒子循环肿瘤细胞
公开(公告)号：EP1874920A4
公开(公告)日：2009-11-04
申请号：EP06749394
申请日：2006-04-05
发明人： FUCHS MARTIN , TONER MEHMET , WANG YING-XIN , HUANG YI-SHUIAN , HUANG LOTIEN RICHARD , KRUEGER NEIL X
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0487 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N33/574 , G01N2015/1006 , G01N2015/1087 , G01N2021/0346 , G01N2800/52
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2.发明公开MAGNETIC DEVICE FOR ISOLATION OF CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT 审中-公开在微流体环境隔离单元和生物分子的磁性器件
公开(公告)号：EP1776449A4
公开(公告)日：2009-08-12
申请号：EP05724574
申请日：2005-03-03
发明人： COSMAN MAURY D , KAPUR RAVI , CARVALHO BRUCE L , BARBER TOM , BALIS ULYSSES J , TONER MEHMET , HUANG LOTIEN RICHARD
IPC分类号： C12N13/00 , B01L3/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/551 , G01N33/553
CPC分类号： G01N33/54326 , B01L3/5027
摘要： The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis.
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3.发明公开DEVICES AND METHOD FOR ENRICHMENT AND ALTERATION OF CELLS AND OTHER PARTICLES 有权装置和方法进行浓缩和细胞及其它颗粒的改变
公开(公告)号：EP1866410A4
公开(公告)日：2009-11-04
申请号：EP06740612
申请日：2006-04-05
发明人： HUANG LOTIEN RICHARD , BARBER THOMAS A , CARVALHO BRUCE L , KAPUR RAVI , VERNUCCI PAUL , TONER MEHMET , WANG ZIHUA
CPC分类号： B03C1/30 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , B01L2400/0472 , B01L2400/0487 , B01L2400/086 , B03C1/32 , B03C2201/18 , B33Y80/00 , C12M47/04 , C12M47/06 , G01N1/40 , G01N1/4077 , G01N33/5044 , G01N2035/00237 , Y10T137/0318 , Y10T137/8593 , Y10T436/25 , Y10T436/25375
摘要： A device comprising a first region comprising a first array of obstacles through which particles can be flowed, wherein the first array of obstacles deterministically directs particles having a hydrodynamic size above a critical size in a first direction and particles having a hydrodynamic size below the critical size in a second direction. The first array of obstacles form a network of gaps, wherein a fluid passing through the gaps is divided unequally into a major flux and a minor flux so that particles having the hydrodynamic size above the critical size are displaced in the network and particles having the hydrodynamic size below the critical size are not displaced in the network. The device further comprises a bypass channel disposed in fluid communication with the first region, wherein the first array of obstacles directs the particles having the hydrodynamic size above the critical size either toward or away from the bypass channel.
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公开(公告)号：EP1931800A4
公开(公告)日：2011-06-15
申请号：EP06803736
申请日：2006-09-15
发明人： KAPUR RAVI , TONER MEHMET , HUANG LOTIEN RICHARD , BARBER TOM , CARVALHO BRUCE , GRAY DARREN , BALIS ULYSSES , WALSH JOHN , GRISHAM MICHAEL , TOMPKINS RON , SCHMIDT MARTIN
CPC分类号： G01N33/80 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , B03C2201/18 , B03C2201/26 , B82Y15/00 , B82Y30/00 , G01N1/4077 , G01N33/54366 , G01N33/569 , G01N33/574 , G01N2001/4088 , G01N2333/805 , G01N2800/387 , G06F19/18
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