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公开(公告)号：EP1292573A2
公开(公告)日：2003-03-19
申请号：EP01937424.8
申请日：2001-05-16
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , MALLAMO, John, P. , VAUGHT, Jeffry, L. , MILLER, Matthew, S.
IPC分类号： C07C323/60 , C07C317/44 , C07D333/18 , C07D277/26 , C07D417/06 , C07D231/54 , A61K31/165 , A61K31/381 , A61K31/416 , A61K31/427 , A61P1/14 , A61P9/10 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D495/04 , C07C317/44 , C07C323/60 , C07C2603/18 , C07D207/16 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06
摘要： The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredness Parkinson's disease, cerebral ischaemia, stroke, sleep apneas, eating disorders, attention deficit hyperactivity disorder, cognitive dysfunction or fatigue, for the promotion of wakefulness, stimulation of appetite or weight gain or for the treatment of disorders associated with hypofunctionality of the cerebral cortex such as depression, schizophrenia and chronic fatigue syndrome.
摘要翻译： 本发明涉及式（I）的取代的硫代乙酰胺：其中Ar 1，Ar 2，R 1 -R 4和n如权利要求中所定义，其制备方法和硫代乙酰胺用于治疗嗜睡，疲劳，帕金森氏症 疾病，脑缺血，中风，睡眠呼吸暂停，进食障碍，注意缺陷多动障碍，认知功能障碍或疲劳; 用于促进觉醒，刺激食欲或体重增加或用于治疗与大脑皮质功能低下相关的疾病，例如抑郁症，精神分裂症和慢性疲劳综合征。 。
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公开(公告)号：EP0786996A1
公开(公告)日：1997-08-06
申请号：EP95940706.0
申请日：1995-11-03
申请人： CEPHALON, INC.
IPC分类号： C12N9 , A61K31 , A61P43 , C07C59 , C07D235 , C07D249 , C07D311 , C07D405 , C07D471 , C07D521
CPC分类号： C07D405/12 , C07C59/84 , C07D235/22 , C07D249/18 , C07D311/82 , C07D471/04
摘要： The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of the protease inhibitors are also described.
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3.发明授权NOVEL QUINOLINE- AND NAPHTHALENECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING CALPAIN 失效喹啉和NAPHTHALINCARBOXAMIDE，药物制剂以及抑制蛋白酶方法
公开(公告)号：EP0983243B1
公开(公告)日：2004-06-16
申请号：EP98910350.2
申请日：1998-03-13
IPC分类号： C07D215/52 , C07D401/12 , C07D401/06 , C07D401/10 , A61K31/47
CPC分类号： C07D215/50 , C07D215/22 , C07D215/52 , C07D221/18 , C07D401/06 , C07D401/10
摘要： Pharmaceutical compositions and methods of inhibiting calpain using novel quinoline- or naphthalenecarboxamides are disclosed.
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公开(公告)号：EP0918777B1
公开(公告)日：2002-08-28
申请号：EP97927906.4
申请日：1997-06-02
IPC分类号： C07D498/22 , A61K31/55
CPC分类号： C07D498/22
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公开(公告)号：EP1115390A1
公开(公告)日：2001-07-18
申请号：EP99969333.6
申请日：1999-09-20
申请人： CEPHALON, INC.
IPC分类号： A61K31/16 , A61K31/27 , A61K31/215 , C07C233/05 , C07C259/04 , C07C269/00
CPC分类号： C07C271/22 , C07C259/06 , C07C311/06 , C07C2601/14
摘要： The present invention is directed to hydroxamate-containing inhibitors of cysteine and serine proteases. Methods for the use of the protease inhibitors are also described.
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公开(公告)号：EP0918777A1
公开(公告)日：1999-06-02
申请号：EP97927906.0
申请日：1997-06-02
CPC分类号： C07D498/22
摘要： Disclosed herein are selected indolocarbazole derivatives which are represented by general formula (I). The compounds are useful for enhancing the function and/or survival of a trophic factor responsive cell. They inhibit interleukin-2 production and have immunosuppressive activity.
摘要翻译： 本文公开了由通式（I）表示的选择的吲哚并咔唑衍生物。 该化合物可用于增强营养因子应答细胞的功能和/或存活。 它们抑制白细胞介素-2的产生并具有免疫抑制活性。
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公开(公告)号：EP1438288B1
公开(公告)日：2009-04-29
申请号：EP02786511.2
申请日：2002-10-25
申请人： CEPHALON, INC.
发明人： BACON, Edward, R. , CHATTERJEE, Sankar , DUNN, Derek , MALLAMO, John, P. , MILLER, Matthew, S. , TRIPATHY, Rabindranath , VAUGHT, Jeffry, L.
IPC分类号： C07C317/44 , C07C323/60 , C07D207/40 , C07D211/88 , C07D231/54 , C07D277/26 , C07D295/18 , C07D333/18 , C07D417/06 , A61K31/165 , A61P1/14 , A61P9/10 , A61P25/16 , A61P25/18 , A61P25/28
CPC分类号： C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要： The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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8.发明授权NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN 失效新INDOLCARBOXAMIDE，药物组合物和蛋白酶的抑制方法
公开(公告)号：EP1018878B1
公开(公告)日：2004-10-06
申请号：EP98909146.7
申请日：1998-03-13
IPC分类号： A61K31/405 , C07D209/42
CPC分类号： C07D209/42
摘要： Pharmaceutical compositions and methods of inhibiting calpain using novel indolecarboxamides are disclosed.
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公开(公告)号：EP1083903B1
公开(公告)日：2004-08-25
申请号：EP99927234.7
申请日：1999-06-04
申请人： CEPHALON, INC.
发明人： SINGH, Jasbir , HUDKINS, Robert, L. , MALLAMO, John, P. , UNDERINER, Theodore, L. , TRIPATHY, Rabindranath
IPC分类号： A61K31/55 , C07D498/22
CPC分类号： C07D498/22
摘要： The present invention is directed to novel fused aryl and heteroaryl bridged indenopyrrolocarbazoles which are useful, inter alia, as therapeutic agents. The invention is also directed to methods for making and using the bridged indenopyrrolocarbazoles.
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公开(公告)号：EP0871454B1
公开(公告)日：2003-11-12
申请号：EP96923756.9
申请日：1996-07-12
申请人： CEPHALON, INC.
IPC分类号： A61K31/66 , A61K31/665 , A61K31/675 , C07F9/09 , C07F9/6574 , C07K5/06
CPC分类号： C07F9/091 , A61K38/00 , C07F9/3211 , C07F9/3252 , C07F9/3264 , C07F9/4006 , C07F9/4065 , C07F9/4075 , C07F9/5721 , C07F9/6533 , C07F9/657163 , C07F9/65742 , C07K5/06191
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