-
1.发明公开VACCINES AND COMPOSITIONS AGAINST STREPTOCOCCUS PNEUMONIAE 审中-公开IMP FE E E E E E E E E E E E E E E E E E E
公开(公告)号：EP2448592A4
公开(公告)日：2013-04-24
申请号：EP10800303
申请日：2010-06-29
发明人： GIERAHN TODD , MALLEY RICHARD
IPC分类号： A61K38/02 , A61K31/04 , A61K38/16 , A61K39/09 , C07K14/315
CPC分类号： A61K38/16 , A61K38/02 , A61K39/00 , C07K14/3156
摘要： Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
摘要翻译： 肺炎链球菌是一个主要的健康问题，特别是在非常年轻，老年或免疫功能低下的患者。 本公开尤其提供了肺炎链球菌中的某些高效疫苗和药物组合物。 抗原可以用于治疗或预防。
-
公开(公告)号：EP2665490A4
公开(公告)日：2015-07-01
申请号：EP12736908
申请日：2012-01-20
发明人： GIERAHN TODD , MALLEY RICHARD
CPC分类号： A61K39/092 , A61K38/04 , A61K39/02
摘要： Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromized patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae. The antigens may be used therapeutically or prophylactically.
-
3.发明公开MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF 审中-公开具有多种抗原和方法免疫原性其组成及其用途
公开(公告)号：EP2706991A4
公开(公告)日：2015-05-06
申请号：EP12781636
申请日：2012-05-11
发明人： MALLEY RICHARD , LU YINGJIE , ZHANG FAN
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
-
4.发明公开MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS 审中-公开修饰型生物素结合蛋白，IT和应用程序蛋白融合
公开(公告)号：EP2709603A4
公开(公告)日：2015-08-26
申请号：EP12782582
申请日：2012-05-11
发明人： MALLEY RICHARD , LU YINGJIE , ZHANG FAN
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
-
公开(公告)号：EP2550289A4
公开(公告)日：2013-11-27
申请号：EP11754142
申请日：2011-03-11
发明人： MALLEY RICHARD , LU YINGJIE , MOFFITT KRISTIN L
IPC分类号： C07K1/02 , A61K39/00 , C07K14/195 , G01N33/53
CPC分类号： A61K39/092 , A61K2039/55544 , A61K2039/55583 , A61K2039/70 , C07K14/3156 , C07K2319/00
-
6.发明公开PROTEIN ANTIGENS THAT PROVIDE PROTECTION AGAINST PNEUMOCOCCAL COLONIZATION AND/OR DISEASE 审中-公开蛋白抗原保护针对肺炎球菌定植和/或侵扰
公开(公告)号：EP2953638A4
公开(公告)日：2016-08-03
申请号：EP14748672
申请日：2014-02-07
发明人： MALLEY RICHARD , LU YINGJIE , ZHANG FAN
IPC分类号： A61K38/00
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6087 , A61K2039/625 , C07K14/3156
摘要： The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., IL-17A response, a T cell-mediated and/or B-cell-mediated immune responses). The present invention also provides methods of prophylaxis and/or treatment of pneumococcal-mediated diseases, such as sepsis, comprising administering an immunogenic composition including one or more of a combination of pneumococcal antigens or functional fragments thereof as disclosed herein. In some embodiments, one or more pneumococcal antigens can be present in a polysaccharide conjugate. The compositions induce an anti-pneumoccocus immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and/or therapeutically to induce a thereapeutic immune response to an infected individual.
-
公开(公告)号：EP2804627A4
公开(公告)日：2015-12-30
申请号：EP13738798
申请日：2013-01-18
发明人： FLECHTNER JESSICA , MALLEY RICHARD
IPC分类号： A61K39/09
CPC分类号： C07K14/3156 , A61K39/092 , A61K39/39 , C07K2319/00
摘要： Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in Streptococcus pneumoniae that contain fusion proteins. The antigens may be used therapeutically or prophylactically.
摘要翻译： 肺炎链球菌是一个主要的健康问题，特别是在非常年轻，老年或免疫功能低下的患者。 本公开尤其提供了含有融合蛋白的肺炎链球菌中的某些高效疫苗和药物组合物。 抗原可以用于治疗或预防。
-
公开(公告)号：EP2485764A4
公开(公告)日：2014-01-29
申请号：EP10822835
申请日：2010-10-12
发明人： MALLEY RICHARD , ANDERSON PORTER , LU YINGJIE , ALDERSON MARK , ROBERTSON GEORGE A , MAISONNEUVE JEAN-FRANCOIS LUCIEN , TATE ANDREA MARIA , DE OLIVEIRA DIAS WALDELY , MIAMONI GONCALVES VIVIANE
IPC分类号： A61K39/395 , A61K39/02 , A61K39/09 , A61P31/00
CPC分类号： A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/55505 , A61K2039/55544
摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
-
公开(公告)号：EP2293815A4
公开(公告)日：2013-04-03
申请号：EP09751641
申请日：2009-05-22
发明人： LU YING-JIE , MALLEY RICHARD
IPC分类号： A61K39/385 , A61K39/09
CPC分类号： A61K39/092 , A61K2039/543 , A61K2039/55505 , A61K2039/6068 , A61K2039/6087 , C07K2319/00
摘要： An immunogenic composition comprising a fusion protein-polysaccharide conjugate consisting of a polysaccharide (PS) or pneumococcal bacterial cell wall polysaccharide (CWPS) conjugated to X:PdT where PdT represents the nonhemolytic variant of pneumolysin and X represents an antigenic peptide or protein of interest is provided. The immunity to X is synergistically enhanced by the fusion conjugate. Methods of protecting a subject from pneumococcal colonization or disease by administering an immunogenic composition including a fusion protein (PsaA:PdT) containing truncated PsaA and the nonhemolytic variant of pneumolysin (PdT) conjugated with CWPS (PsaA:PdT-CWPS) is also provided.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.008 秒)
