公开(公告)号：EP1105474A2

公开(公告)日：2001-06-13

申请号：EP99925624.1

申请日：1999-05-13

申请人： Chiron Corporation ,  HYSEQ, INC.

发明人： WILLIAMS, Lewis, T ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  GIESE, Klaus ,  RANDAZZO, Filippo ,  KENNEDY, Giulia C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  JONES, Lee William ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C07K14/47 ,  C12Q1/68 ,  C07K16/18

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1190058A2

公开(公告)日：2002-03-27

申请号：EP98965500.6

申请日：1998-12-25

申请人： CHIRON CORPORATION ,  Hyseq Inc.

发明人： WILLIAMS, Lewis T. ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  GIESE, Klaus ,  RANDAZZO, Filippo ,  KENNEDY, Giulia, C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA,Veronica ,  JONES, Lee, William ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1309679A2

公开(公告)日：2003-05-14

申请号：EP01964160.4

申请日：2001-08-16

申请人： CHIRON CORPORATION ,  Hyseq Inc.

发明人： ESCOBEDO, Jaime ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  RANDAZZO, Filippo ,  LAMSON, George ,  SCOTT, Elizabeth, M. ,  ZHANG, Guozhong ,  KASSAM, Altaf ,  POT, David ,  LABAT, Ivan

IPC分类号： C12N15/00

CPC分类号： C07K14/47

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1268528A2

公开(公告)日：2003-01-02

申请号：EP01962418.8

申请日：2001-03-27

申请人： Chiron Corporation ,  Hyseq Inc.

发明人： WILLIAMS, Lewis T. ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  HE, Zhijun ,  RANDAZZO, Filippo ,  KENNEDY, Giulia C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  JONES, Lee William ,  STACHE-CRAIN, Birgit

IPC分类号： C07K14/00

CPC分类号： C07K14/47

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variant thereof, to genes corresponding to theses polynucleotides and to proteins expressed by the genes. This invention also relates to diagnostic and therapeutic agents employing such novel polynucleotides, their corresponding genes or gene products, ∫i⊃e.g.∫/i⊃, these genes and proteins, including probes, antisense constructs, and antibodies.

摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

公开(公告)号：EP1263956A2

公开(公告)日：2002-12-11

申请号：EP01918557.8

申请日：2001-03-09

申请人： Chiron Corporation ,  Hyseq Inc.

发明人： WILLIAMS, Lewis, T. ,  ESCOBEDO, Jaime ,  INNIS, Michael, A. ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  RANDAZZO, Filippo ,  KENNEDY, Giulia, C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C12N15/10 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/47

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP0915904A1

公开(公告)日：1999-05-19

申请号：EP97926403.0

申请日：1997-05-06

申请人： CHIRON CORPORATION

发明人： RANDAZZO, Filippo

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K48 ,  A61P35 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12P21 ,  C12Q1

CPC分类号： C07K14/4745 ,  A61K38/00

摘要： Mammalian Scm gene and amino acid sequences encoded by the mammalian Scm gene are described. The mammalian Scm gene and gene products are useful for diagnostic and therapeutic applications in proliferative and developmental disorders. Modulators of mammalian Scm can be identified using the disclosed genes. The modulators can be used in the context of cancer therapy or a treatment of a developmental disorder. Scm is also useful for inducing differentiation in a population of progenitor cells.

公开(公告)号：EP0960120A1

公开(公告)日：1999-12-01

申请号：EP97924583.0

申请日：1997-05-06

申请人： CHIRON CORPORATION

发明人： RANDAZZO, Filippo

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K48 ,  A61P35 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12P21 ,  C12Q1

CPC分类号： C07K14/4745 ,  A61K38/00

摘要： Mammalian Scm gene and amino acid sequences encoded by the mammalian Scm gene, are described. The mammalian Scm gene and gene products are useful for diagnostic and therapeutic applications in proliferative and developmental disorders. Modulators of mammalian Scm can be identified using the disclosed genes. The modulators can be used in the context of cancer therapy or a treatment of a developmental disorder. Scm is also useful for inducing de-differentiation in a population of progenitor cells.

公开(公告)号：EP1290029A2

公开(公告)日：2003-03-12

申请号：EP01942047.0

申请日：2001-06-05

申请人： CHIRON CORPORATION

发明人： REINHARD, Christoph ,  JEFFERSON, Anne, B. ,  WINTER, Jill, A. ,  RANDAZZO, Filippo

IPC分类号： C07K14/705 ,  C12N15/11 ,  A61K48/00 ,  A61P35/00 ,  C12Q1/68

CPC分类号： C12N15/1138 ,  A61K38/00 ,  A61K48/00 ,  C07K14/715 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Modulators of NET-4 are provided that reduce the expression or biological activities of NET-4 or the expression of NET-4mRNA in a mammalian cell. NET-4 modulators include antisense molecules, NET-4 modulators find use in compositions and methods for decreasing NET-4 gene expression as well as methods for inhibiting the proliferation of mammalian cells, including tumor cells, and methods for treating neoplastic diseases.

公开(公告)号：EP0927250A1

公开(公告)日：1999-07-07

申请号：EP97938553.0

申请日：1997-08-22

申请人： CHIRON CORPORATION

发明人： RANDAZZO, Filippo

IPC分类号： C07K14 ,  C12N1 ,  C12N15 ,  A61K38

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00

摘要： A novel human tumor suppressor gene termed polyhomeotic 1 is disclosed. The human polyhomeotic 1 gene and protein can be used as therapeutic and diagnostic tools for proliferative and developmental disorders. The gene can also be used to identify a p13 region of human chromosome 12.

摘要翻译： 公开了一种称为polyhomeotic 1的新型人类肿瘤抑制基因。 人多基因1基因和蛋白质可以用作增殖性和发育性疾病的治疗和诊断工具。 该基因也可用于鉴定人染色体12的p13区域。

公开(公告)号：EP0938559A2

公开(公告)日：1999-09-01

申请号：EP97948415.0

申请日：1997-11-19

申请人： CHIRON CORPORATION

发明人： RANDAZZO, Filippo

IPC分类号： C07K14 ,  C12N15 ,  A61K38 ,  A61K48

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

摘要： A human tumor suppressor gene termed polyhomeotic 2 and its expression products can be used as therapeutic, prognostic, and diagnostic tools for proliferative and developmental disorders. Nucleotide sequences of the gene can also be used to identify a p34.3 region of a human chromosome 1.

摘要翻译： 称为polyhomeotic 2及其表达产物的人类肿瘤抑制基因可用作增殖性和发育性疾病的治疗，预后和诊断工具。 该基因的核苷酸序列也可用于鉴定人染色体1的p34.3区域。