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公开(公告)号：EP2813512A4
公开(公告)日：2016-02-10
申请号：EP12861199
申请日：2012-12-28
发明人： KARIYUKI SHIORI , IIDA TAKEO , KOJIMA MIKI , TAKEYAMA RYUICHI , TANADA MIKIMASA , KOJIMA TETSUO , IIKURA HITOSHI , MATSUO ATSUSHI , SHIRAISHI TAKUYA , EMURA TAKASHI , NAKANO KAZUHIKO , TAKANO KOJI , ASOU KOUSUKE , TORIZAWA TAKUYA , TAKANO RYUSUKE , HISADA NOZOMI , MURAO NAOAKI , OHTA ATSUSHI , KIMURA KAORI , YAMAGISHI YUSUKE , KATO TATSUYA
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2.发明公开MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权多用途抗生素MLEEZIFISCHES抗生素MLEEKINL MIT EINER BLUTGERINNUNGSFAKTOR-VIII-WECHSELFUNKTION
公开(公告)号：EP2644698A4
公开(公告)日：2015-07-01
申请号：EP11842145
申请日：2011-11-17
发明人： IGAWA TOMOYUKI , SAMPEI ZENJIRO , KOJIMA TETSUO , SOEDA TETSUHIRO , MUTO ATSUSHI , KITAZAWA TAKEHISA , NISHIDA YUKIKO , IMAI CHIFUMI , SUZUKI TSUKASA , YOSHIHASHI KAZUTAKA
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译： 各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能代替血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能 活化血液凝固因子IX。 从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。
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公开(公告)号：EP1693386A4
公开(公告)日：2008-12-31
申请号：EP03770128
申请日：2003-11-04
发明人： MIYAZAKI TARO , KOJIMA TETSUO
CPC分类号： C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/626
摘要： Giving attention to the fact that no secretion occurs by H chain in one side due to "knobs-into-holes", it is found out that a target bispecific antibody can be preferentially formed by first expressing H chain and L chain in one side, after inhibiting the expression, expressing H chain and L chain in the other side to construct target HL molecules (HaLa and HbLb) and then pairing the H chains together (H2L2).
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公开(公告)号：EP1605058A4
公开(公告)日：2006-04-19
申请号：EP04703920
申请日：2004-01-21
发明人： KOJIMA TETSUO
CPC分类号： C07K16/005 , C07K2317/31 , C07K2317/55
摘要： A method of screening a common light chain which comprises: (a) the step of producing a host secreting the heavy chain of an antibody binding to a desired antigen; (b) the step of transferring an antibody light chain library into the host of the step (a) and thus producing libraries presenting antibodies consisting of the above heavy chain and the above light chain; (c) selecting a library presenting an antibody binding specifically to the desired antigen as described in the step (a); (d) the step of transferring the library selected in the step (c) into a host secreting the heavy chain of an antibody binding to a desired antigen, which is different from the antigen of the step (a), and thus producing libraries presenting antibodies consisting of the heavy chain and the light chain; and (e) selecting a library presenting an antibody binding specifically to the desired antigen as described in the step (d).
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公开(公告)号：EP2330193A4
公开(公告)日：2012-07-25
申请号：EP09816184
申请日：2009-09-25
发明人： IGAWA TOMOYUKI , ISHII SHINYA , MAEDA ATSUHIKO , SAKURAI MIKA , KOJIMA TETSUO , TACHIBANA TATSUHIKO , SHIRAIWA HIROTAKE , TSUNODA HIROYUKI , HIGUCHI YOSHINOBU
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00
CPC分类号： C07K16/2866 , A61K39/00 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP1876236A4
公开(公告)日：2009-07-29
申请号：EP06730769
申请日：2006-03-31
IPC分类号： C12N15/09 , A61K39/395 , A61P7/04 , C07K16/40 , C07K16/46
CPC分类号： C07K16/36 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/75
摘要： The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.
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公开(公告)号：EP1033374A4
公开(公告)日：2006-06-14
申请号：EP98955942
申请日：1998-11-26
发明人： KITAMURA TOSHIO , KOJIMA TETSUO
IPC分类号： C07K14/715 , C12N15/12 , C12N15/62 , C12N15/867 , C12Q1/68 , C12N5/16
CPC分类号： C12N15/625 , C07K2319/02 , C07K2319/75 , C12N2799/027 , C12Q1/6897
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公开(公告)号：EP2206775A4
公开(公告)日：2010-11-03
申请号：EP08833735
申请日：2008-09-26
发明人： IGAWA TOMOYUKI , SAKURAI MIKA , KOJIMA TETSUO , TACHIBANA TATSUHIKO , SHIRAIWA HIROTAKE , TSUNODA HIROYUKI , MAEDA ATSUHIKO
IPC分类号： C12N15/09 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6854 , G01N33/6869 , G01N2333/7155 , G01N2500/04 , G01N2500/10
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公开(公告)号：EP1688488A4
公开(公告)日：2008-03-05
申请号：EP04792180
申请日：2004-10-08
CPC分类号： C07K16/36 , C07K16/2866 , C07K2317/24 , C07K2317/31 , C07K2317/622
摘要： A bispecific antibody functionally substituting for blood coagulation factor VIII/activated blood coagulation factor VIII , which binds to both of blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and enhances an enzymatic reaction, is successfully constructed.
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公开(公告)号：EP1505148A4
公开(公告)日：2006-07-26
申请号：EP03719213
申请日：2003-04-25
发明人： KOJIMA TETSUO , SENOO CHIAKI
IPC分类号： A61P25/00 , A61P37/00 , C12P21/08 , C40B30/04 , G01N33/50 , G01N33/68 , C12N15/00 , A61K39/395 , C07K16/44 , C12N5/10 , C12Q1/02 , G01N33/15
CPC分类号： C40B30/04 , G01N33/5008
摘要： An agonistic antibody can be efficiently screened by superinfecting a cell strain, which proliferates depending on a ligand (factor), with antibody libraries respectively to various receptor chains and collecting an antibody gene from an autonomously growing strain by autocline of an agonistic antibody formed from an appropriate combination. Since antibodies are used as libraries in this method, the screening can be performed efficiently and conveniently without resort to troublesome operations.
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