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公开(公告)号：EP2330193A4
公开(公告)日：2012-07-25
申请号：EP09816184
申请日：2009-09-25
发明人： IGAWA TOMOYUKI , ISHII SHINYA , MAEDA ATSUHIKO , SAKURAI MIKA , KOJIMA TETSUO , TACHIBANA TATSUHIKO , SHIRAIWA HIROTAKE , TSUNODA HIROYUKI , HIGUCHI YOSHINOBU
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00
CPC分类号： C07K16/2866 , A61K39/00 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2241332A4
公开(公告)日：2011-01-26
申请号：EP08857461
申请日：2008-12-05
IPC分类号： A61K45/00 , A61K39/395 , A61P17/04 , C07K16/28
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/76
摘要： The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus.
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公开(公告)号：EP1724287A4
公开(公告)日：2010-10-27
申请号：EP05720011
申请日：2005-03-04
发明人： IKEYA HITOSHI , MORIKAWA TADASHI , TAKAHASHI KOICHI , TAMURA TATSUYA , OKAMACHI AKIRA , ISHIZAWA TAKENORI , SATO HARUHIKO , HIGUCHI YOSHINOBU
IPC分类号： C08B37/08 , A61K31/519 , A61K47/48 , A61P19/02 , C07D475/10 , C07K5/00 , C07K9/00
CPC分类号： C08B37/0072 , A61K47/61 , A61K47/65 , C07D475/08 , C07K9/003
摘要： An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
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