公开(公告)号：EP0874902A2

公开(公告)日：1998-11-04

申请号：EP97902911.0

申请日：1997-01-10

申请人： CORIXA CORPORATION

发明人： FRUDAKIS, Tony, N. ,  SMITH, John, M. ,  REED, Steven, G.

IPC分类号： G01N33 ,  A61K35 ,  A61K39 ,  A61K48 ,  C07K14 ,  C07K16 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38 ,  C12R1

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/82 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

公开(公告)号：EP1283885A2

公开(公告)日：2003-02-19

申请号：EP01939366.9

申请日：2001-05-22

申请人： CORIXA CORPORATION

发明人： FRUDAKIS, Tony, N. ,  REED, Steven, G. ,  SMITH, John, M. ,  MISHER, Lynda, E. ,  DILLON, Davin, C. ,  RETTER, Marc, W. ,  WANG, Aijun ,  SKEIKY, Yasir, A., W. ,  HARLOCKER, Susan, L. ,  DAY, Craig, H.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/47 ,  C07K16/18 ,  A61K38/00 ,  G01N33/50

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。

公开(公告)号：EP1155322B1

公开(公告)日：2007-10-10

申请号：EP00910338.3

申请日：2000-02-24

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  SKEIKY, Yasir, A., W. ,  LODES, Michael, J. ,  HOUGHTON, Raymond, L. ,  SMITH, John, M. ,  MCNEILL, Patricia, D.

IPC分类号： G01N33/569 ,  C07K14/44

CPC分类号： G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/44 ,  G01N2333/44 ,  Y02A50/414

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

公开(公告)号：EP1169444A2

公开(公告)日：2002-01-09

申请号：EP00921869.4

申请日：2000-04-07

申请人： CORIXA CORPORATION

发明人： FRUDAKIS, Tony, N. ,  SMITH, John, M. ,  REED, Steven, G. ,  MISHER, Lynda, E. ,  RETTER, Marc, W. ,  DILLON, Davin, C.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C07K19/00 ,  C12N15/62 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  C12N5/08 ,  G01N33/574 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K2319/00

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

公开(公告)号：EP1155322A1

公开(公告)日：2001-11-21

申请号：EP00910338.3

申请日：2000-02-24

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  SKEIKY, Yasir, A., W. ,  LODES, Michael, J. ,  HOUGHTON, Raymond, L. ,  SMITH, John, M. ,  MCNEILL, Patricia, D.

IPC分类号： G01N33/569 ,  C07K14/44

CPC分类号： G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/44 ,  G01N2333/44 ,  Y02A50/414

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

公开(公告)号：EP1038000A1

公开(公告)日：2000-09-27

申请号：EP98962923.3

申请日：1998-12-04

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  SKEIKY, Yasir, A., W. ,  LODES, Michael, J. ,  HOUGHTON, Raymond, L. ,  SMITH, John, M. ,  McNEILL, Patricia, D.

IPC分类号： C12N15/31 ,  C07K14/44 ,  G01N33/569 ,  G01N33/577 ,  A61K39/005

CPC分类号： G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  G01N2333/44 ,  Y02A50/414

摘要： Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi antigens. The compounds are useful in a variety of immunoassays for detecting T. cruzi infection. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for inducing protective immunity against Chagas' disease in individuals exposed to T. cruzi.

公开(公告)号：EP0975666A2

公开(公告)日：2000-02-02

申请号：EP98915351.5

申请日：1998-04-09

申请人： CORIXA CORPORATION

发明人： FRUDAKIS, Tony, N. ,  SMITH, John, M. ,  REED, Steven, G.

IPC分类号： C07K14/47 ,  C07K14/82 ,  C07K14/15 ,  C12Q1/68 ,  G01N33/574 ,  A61K38/17 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/82 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer patient.