公开(公告)号：EP1287026B1

公开(公告)日：2005-11-23

申请号：EP01928377.9

申请日：2001-04-05

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  CAMPOS-NETO, Antonio ,  WEBB, John, R. ,  DILLON, Davin, C. ,  SKEIKY, Yasir, A., W. ,  BHATIA, Ajay ,  COLER, Rhea, M. ,  PROBST, Peter

IPC分类号： C07K14/44 ,  C12N15/62

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y02A50/41

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

公开(公告)号：EP1420814A2

公开(公告)日：2004-05-26

申请号：EP02753437.9

申请日：2002-08-05

申请人： CORIXA CORPORATION

发明人： FANGER, Gary, R. ,  HIRST, Shannon, Kathleen ,  DILLON, Davin, C. ,  FOY, Teresa, M. ,  HOUGHTON, Raymond, L. ,  PERSING, David, H. ,  KALOS, Michael, D.

IPC分类号： A61K39/00

CPC分类号： C07K14/4748 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2710/24143 ,  C12N2740/10022 ,  C12N2740/14022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：EP0854924B1

公开(公告)日：2003-06-25

申请号：EP96933854.0

申请日：1996-09-20

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  CAMPOS-NETO, Antonio ,  WEBB, John, R. ,  DILLON, Davin, C. ,  SKEIKY, Yasir, A., W.

IPC分类号： C12N15/30 ,  C07K14/44 ,  C12N15/70 ,  C12N1/21 ,  A61K39/008 ,  G01N33/569

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/41 ,  Y10S530/806

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

公开(公告)号：EP1287026A2

公开(公告)日：2003-03-05

申请号：EP01928377.9

申请日：2001-04-05

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  CAMPOS-NETO, Antonio ,  WEBB, John, R. ,  DILLON, Davin, C. ,  SKEIKY, Yasir, A., W. ,  BHATIA, Ajay ,  COLER, Rhea, M. ,  PROBST, Peter

IPC分类号： C07K14/44 ,  C12N15/30 ,  A61K39/008 ,  G01N33/569

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y02A50/41

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

公开(公告)号：EP1173570A2

公开(公告)日：2002-01-23

申请号：EP00928254.2

申请日：2000-04-21

申请人： CORIXA CORPORATION

发明人： WANG, Tongtong ,  DILLON, Davin, C.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C12N5/10 ,  A61K38/17 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C12N9/6491 ,  C07K14/4741 ,  C07K14/52 ,  C07K14/705 ,  C07K14/78

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as head and neck cancer and lung cancer, are disclosed. Compositions may comprise one or more head and neck tumor proteins, immunogenic portions thereof or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a head and neck tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as head and neck cancer and lung cancer. Diagnostic methods based on detecting a head and neck tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：EP1183348B1

公开(公告)日：2011-06-29

申请号：EP00919352.5

申请日：2000-02-15

申请人： CORIXA CORPORATION

发明人： YUQIU, Jiang ,  DILLON, Davin, C. ,  MITCHAM, Jennifer, Lynn ,  XU, Jiangchun ,  HARLOCKER, Susan, L.

IPC分类号： C12N15/12 ,  C12N15/52 ,  C07K14/47 ,  C12N9/00 ,  C12N5/10 ,  C12N1/21 ,  A61K38/17 ,  A61K39/00 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  A61K39/395 ,  A61K35/12 ,  C07K19/00 ,  C12N15/62 ,  C12N5/00 ,  G01N33/68 ,  C12Q1/68 ,  C12N15/11

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portion thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：EP1515982A2

公开(公告)日：2005-03-23

申请号：EP02725984.5

申请日：2002-05-09

申请人： CORIXA CORPORATION

发明人： XU, Jiangchun ,  DILLON, Davin, C. ,  MITCHAM, Jennifer, L. ,  HARLOCKER, Susan, L. ,  JIANG, Yuqiu ,  HENDERSON, Robert, A. ,  KALOS, Michael, D. ,  FANGER, Gary, R. ,  RETTER, Marc, W. ,  STOLK, John, A. ,  DAY, Craig, H. ,  VEDVICK, Thomas, S. ,  CARTER, Darrick ,  LI, Samuel, X. ,  WANG, Aijun ,  SKEIKY, Yasir, A., W. ,  HEPLER, William, T. ,  HURAL, John ,  MCNEILL, Patricia, D. ,  HOUGHTON, Raymond L. Carlota ,  VINALS Y DE BASSOLS, Carlota ,  FOY, Teresa M. ,  WATANABE, Yoshihiro ,  DENG, Ta

IPC分类号： C07H21/02 ,  C12N15/63 ,  C12N15/85

CPC分类号： C07K16/3069 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/34 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 披露了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞和对表达此类多肽的细胞具有特异性的T细胞。 所公开的组合物可用于例如疾病的诊断，预防和/或治疗，特别是前列腺癌。

公开(公告)号：EP1283885A2

公开(公告)日：2003-02-19

申请号：EP01939366.9

申请日：2001-05-22

申请人： CORIXA CORPORATION

发明人： FRUDAKIS, Tony, N. ,  REED, Steven, G. ,  SMITH, John, M. ,  MISHER, Lynda, E. ,  DILLON, Davin, C. ,  RETTER, Marc, W. ,  WANG, Aijun ,  SKEIKY, Yasir, A., W. ,  HARLOCKER, Susan, L. ,  DAY, Craig, H.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/47 ,  C07K16/18 ,  A61K38/00 ,  G01N33/50

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。

公开(公告)号：EP1071451A2

公开(公告)日：2001-01-31

申请号：EP99908169.8

申请日：1999-02-17

申请人： CORIXA CORPORATION

发明人： REED, Steven, G. ,  SKEIKY, Yasir, A., W. ,  DILLON, Davin, C. ,  CAMPOS-NETO, Antonio ,  HOUGHTON, Raymond ,  VEDVICK, Thomas, S. ,  TWARDZIK, Daniel, R. ,  LODES, Michael, J. ,  HENDRICKSON, Ronald, C.

IPC分类号： A61K39/04 ,  A61K49/00 ,  G01N33/53 ,  C07K1/00 ,  C12N15/00

CPC分类号： C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

公开(公告)号：EP1005546A2

公开(公告)日：2000-06-07

申请号：EP98906649.3

申请日：1998-02-25

申请人： CORIXA CORPORATION

发明人： XU, Jiangchun ,  DILLON, Davin, C.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N5/10 ,  C12N1/21 ,  A61K38/17 ,  C12N1/19 ,  A61K39/00 ,  C12N15/62

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/90

摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

摘要翻译： 提供了用于治疗前列腺癌的化合物和方法。 本发明的化合物包括多肽至少含有前列腺肿瘤蛋白的一部分。 疫苗和前列腺癌，包括搜索多肽或编码检查的多肽的DNA分子的免疫治疗的药物组合物，所以被提供，连同DNA分子用于制备本发明的多肽。