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公开(公告)号：EP2697252B1
公开(公告)日：2016-08-10
申请号：EP12770605.9
申请日：2012-04-11
发明人： JESSEN, Holly J. , YI, Jian , LUNDORFF, Joshua , LIAO, Hans , NEGRETE-RAYMOND, Ana , SUOMINEN, Pirkko , ARISTIDOU, Aristos
IPC分类号： C12N1/19
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
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2.发明授权LACTIC ACID-PRODUCING YEAST CELLS HAVING NONFUNCTIONAL L-OR D-LACTATE: FERRICYTOCHROME C OXIDOREDUCTASE GENE 有权乳酸生产具有非功能性或L的D- LACTAT酵母细胞：高铁-C氧化还原酶基因：
公开(公告)号：EP1960516B1
公开(公告)日：2012-12-26
申请号：EP06850558.5
申请日：2006-11-17
发明人： MILLER, Matthew , SUOMINEN, Pirkko , ARISTIDOU, Aristos , HAUSE, Benjamin, Matthew , VAN HOEK, Pim , DUNDON, Catherine, Asleson
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
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3.发明公开YEAST CELLS HAVING DISRUPTED PATHWAY FROM DIHYDROXYACETONE PHOSPHATE TO GLYCEROL 有权HEFEZELLEN MIT UNTERBROCHENEM WEG VON DIHYDROXYACETON-PHOSPHATE BIS GLYCERIN
公开(公告)号：EP2001992A2
公开(公告)日：2008-12-17
申请号：EP07753061.6
申请日：2007-03-13
发明人： DUNDON, Catherine, Asleson , SUOMINEN, Pirkko , ARISTIDOU, Aristos , RUSH, Brian, J. , KOIVURANTA, Kari , HAUSE, Benjamin, Matthew , MCMULLIN, Thomas, William , ROBERG-PEREZ, Kevin
IPC分类号： C12N1/18
摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyυeromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
摘要翻译： 在发酵过程中，在发酵条件下和在碳源的存在下培养经遗传修饰以将天然代谢途径从磷酸二羟丙酮磷酸酯切割至甘油的全基因组复制酵母的细胞，以产生 所需的发酵产物，其中甘油产率基于由细胞消耗的碳源的重量小于2％，并且其中将甘油加入到发酵培养基中。
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4.发明授权GENETICALLY MODIFIED YEAST SPECIES AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权基因修饰，其中遗传修饰的酵母是所使用的酵母种类和发酵过程
公开(公告)号：EP1626979B1
公开(公告)日：2012-06-06
申请号：EP04751126.6
申请日：2004-05-03
发明人： RAJGARHIA, Vineet , KOIVURANTA, Kari , PENTTILÄ, Merja , ILMEN, Marja , SUOMINEN, Pirkko , ARISTIDOU, Aristos , MILLER, Chris , OLSON, Stacey , RUOHONEN, Laura
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
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公开(公告)号：EP2697252A2
公开(公告)日：2014-02-19
申请号：EP12770605.9
申请日：2012-04-11
发明人： JESSEN, Holly J. , YI, Jian , LUNDORFF, Joshua , LIAO, Hans , NEGRETE-RAYMOND, Ana , SUOMINEN, Pirkko , ARISTIDOU, Aristos
IPC分类号： C07K14/435 , E21B44/00
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
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