公开(公告)号：EP2794884A1

公开(公告)日：2014-10-29

申请号：EP12859599.8

申请日：2012-12-13

申请人： Codexis, Inc.

发明人： CLARK, Louis ,  KARLSHOEJ, Kristian ,  CHOUDHARY, Patricia

IPC分类号： C12N15/53 ,  C12N1/21 ,  C12N9/02

CPC分类号： C12P7/04 ,  A61K8/342 ,  A61K2800/10 ,  A61Q5/00 ,  A61Q19/00 ,  C07C31/125 ,  C12N9/0008 ,  C12Y102/01 ,  C12Y102/0105 ,  C12Y102/0108 ,  Y02P20/52

摘要： The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides fatty acyl-CoA reductase (FAR) variant enzymes, polynucleotides encoding the FAR variant enzymes, and vectors and host cells comprising polynucleotides encoding the FAR variant enzymes.

公开(公告)号：EP2379713A2

公开(公告)日：2011-10-26

申请号：EP09838003.3

申请日：2009-12-18

申请人： Codexis, Inc.

发明人： DE VRIES, Erik ,  CLARK, Louis ,  MC VICAR, Scott ,  SEGRAVES, Erika ,  SONG, Shiwei ,  TAN, Kheng, Lin

IPC分类号： C12N9/02 ,  C12N15/53 ,  C12N15/70

CPC分类号： C12N9/88 ,  C12P7/02

摘要： The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the engineered HHDH enzymes, host cells capable of expressing the engineered HHDH enzymes, and methods of using the engineered HHDH enzymes to synthesize a variety of chiral compounds including chiral epoxides and chiral alcohols.

公开(公告)号：EP2585587B1

公开(公告)日：2017-08-09

申请号：EP11804150.8

申请日：2011-06-28

申请人： Codexis, Inc.

发明人： BEHROUZIAN, Behnaz ,  CLARK, Louis ,  ZHU, Yihui ,  CLAY, Michael ,  KARLSHOEJ, Kristian

IPC分类号： C12N9/00

CPC分类号： C12N9/0008 ,  C07C1/22 ,  C07K2319/00 ,  C07K2319/036 ,  C10G3/00 ,  C10G3/40 ,  C10G2300/1011 ,  C10G2400/04 ,  C11D3/2003 ,  C11D3/2013 ,  C11D3/2031 ,  C12N9/0006 ,  C12P7/04 ,  Y02P30/20

公开(公告)号：EP2432890B1

公开(公告)日：2015-09-02

申请号：EP10778451.4

申请日：2010-05-21

申请人： Codexis, Inc.

发明人： BEHROUZIAN, Behnaz ,  MCDANIEL, Robert ,  ZHANG, Xiyun ,  CLARK, Louis

IPC分类号： C12P7/64

CPC分类号： C12P7/04 ,  C12N9/0008 ,  C12N9/1288

公开(公告)号：EP2702154A1

公开(公告)日：2014-03-05

申请号：EP12776541.0

申请日：2012-04-27

申请人： Codexis, Inc.

发明人： VOLADRI, Rama ,  ZHANG, Xiyun ,  PATIL, Sachin ,  ELGART, David ,  MILLER, Gregory ,  CLARK, Louis ,  CHAN, Kui

IPC分类号： C12N9/42

CPC分类号： C12N9/2437 ,  C12N9/2434 ,  C12P19/02 ,  C12P19/14

摘要： The present invention relates to cellobiohydrolase variants having improved thermostability and/or thermoactivity in comparison to wild-type
Myceliophthora thermophila CBH2b.

摘要翻译： 本发明涉及与野生型嗜热毁丝霉CBH2b相比具有改善的热稳定性和/或热活性的纤维二糖水解酶变体。

公开(公告)号：EP2443235A2

公开(公告)日：2012-04-25

申请号：EP10790160.5

申请日：2010-06-16

申请人： Codexis, Inc.

发明人： ZHANG, Xiyun ,  YANG, Jie ,  BAIDYAROY, Dipnath ,  POSTLETHWAITE, Sally Rhiannon ,  ANDOR, Attila ,  CLARK, Louis ,  NEWMAN, Lisa, M.

IPC分类号： C12N9/42 ,  C12N15/00

CPC分类号： C12N9/2445 ,  C12N9/2482 ,  C12Y302/01021 ,  Y02E50/17

摘要： The invention relates to recombinantly produced β-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β- glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.

摘要翻译： 本发明涉及与天然存在的蛋白质相比具有增强的热活性的重组产生的和 - 葡萄糖苷酶变体。 本发明还提供了通过鉴定靶标和葡糖苷酶多肽中的性能敏感位置并用热活性增强残基取代该位置处的残基来制备具有改进的热活性的变体和葡萄糖苷酶多肽的方法。

公开(公告)号：EP2443139B1

公开(公告)日：2016-08-10

申请号：EP10790144.9

申请日：2010-06-16

申请人： Codexis, Inc.

发明人： POSTLETHWAITE, Sally, Rhiannon ,  CLARK, Louis ,  CHO, Catherine M

IPC分类号： C12N9/42 ,  C12P7/06 ,  C12P19/14

CPC分类号： C12N9/42 ,  C12N9/2445 ,  C12P7/06 ,  C12P19/14 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

公开(公告)号：EP2748187A1

公开(公告)日：2014-07-02

申请号：EP12825090.9

申请日：2012-07-13

申请人： Codexis, Inc.

发明人： BAIDYAROY, Dipnath ,  CLARK, Louis ,  ELGART, David ,  VOLADRI, Rama ,  ZHANG, Xiyun

IPC分类号： C07K14/37 ,  C12P7/10 ,  C12N15/55 ,  C07H1/00

CPC分类号： C12N9/2437 ,  C12N15/80 ,  C12P7/14 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P7/58 ,  C12P13/14 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01091 ,  Y02E50/16

摘要： The present invention relates to cellobiohydrolase variants having improved thermostability in comparison to wild-type CBH2a.

摘要翻译： 本发明涉及与野生型CBH2a相比具有改善的热稳定性的纤维二糖水解酶变体。

公开(公告)号：EP2504431A1

公开(公告)日：2012-10-03

申请号：EP10833801.3

申请日：2010-11-19

申请人： Codexis, Inc.

发明人： BAIDYAROY, Dipnath ,  CLARK, Louis ,  NEWMAN, Lisa, M.

IPC分类号： C12N9/42

CPC分类号： C12N9/2445 ,  C12P19/14 ,  C12Y302/01021 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention provides compositions and methods for the expression of recombinant β-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.

公开(公告)号：EP2385982A2

公开(公告)日：2011-11-16

申请号：EP10729574.3

申请日：2010-01-08

申请人： Codexis, Inc.

发明人： NEWMAN, Lisa, M. ,  CLARK, Louis ,  CHING, Charlene ,  ZIMMERMAN, Sabrina

IPC分类号： C12N9/04 ,  C12N15/63 ,  C07K14/195

CPC分类号： C12N9/88 ,  C12Y402/01001

摘要： The present disclosure relates to recombinant carbonic anhydrase enzymes having improved properties as compared to a naturally occurring wild type carbonic anhydrase and uses thereof for the sequestration of carbon dioxide as well as for the release of carbon dioxide from a composition comprising bicarbonate. Also provided are polynucleotides encoding the recombinant carbonic anhydrase enzymes and host cells capable of expressing the recombinant carbonic anhydrase enzymes.