公开(公告)号：EP2367928B1

公开(公告)日：2018-03-14

申请号：EP09775365.1

申请日：2009-12-24

申请人： DSM IP Assets B.V.

发明人： Teunissen, , Aloysius Wilhelmus Rudolphus Hubertus ,  De Bont, Johannes Adrianus Maria

IPC分类号： C12N1/14 ,  C12N1/16 ,  C12N1/18 ,  C12N1/19 ,  C12P7/08 ,  C12P7/10 ,  C12P7/16 ,  C12P7/42 ,  C12P7/52 ,  C12P7/54 ,  C12P7/56 ,  C12P7/48

CPC分类号： C12N9/90 ,  C12N9/92 ,  C12N15/52 ,  C12P5/026 ,  C12P7/06 ,  C12P7/14 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/52 ,  C12P7/54 ,  C12P7/56 ,  C12P13/04 ,  C12P17/10 ,  C12P35/00 ,  C12Y503/01005 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02P20/52

摘要： The present invention relates to eukaryotic cells which have the ability to isomerize xylose directly into xylulose by transformation with nucleotide sequences encoding a xylose isomerase that has one or more specific sequence elements typical for isomerases which are functionally expressed in yeasts, such as xylose isomerases obtainable from bacteria of the genera Clostridium and Fusobacterium or a tunicate from the genus Ciona. The cell preferably is a yeast or a filamentous fungus capable of anaerobic alcoholic fermentation. The cells may further comprise one or more genetic modifications that increase the flux of the pentose phosphate pathway or, reduce unspecific aldose reductase activity. The cell preferably has the ability to produce a fermentation product such as ethanol, lactic acid, 3-hydroxy-propionic acid, &bgr;-lactam antibiotics and cephalosporins. Also provided are processes for producing these fermentation products from xylose.

公开(公告)号：EP2681182B1

公开(公告)日：2017-12-27

申请号：EP12714104.2

申请日：2012-03-02

申请人： MICHIGAN BIOTECHNOLOGY INSTITUTE

发明人： HANCHAR, Robert, J. ,  KLEFF, Susanne ,  GUETTLER, Michael, V.

IPC分类号： C07C51/02 ,  C01C1/24 ,  C01D1/20 ,  C07C55/02 ,  C07C55/06 ,  C07C55/10 ,  C07C55/22 ,  C07C57/13 ,  C07C57/15 ,  C12P7/46 ,  C12P7/48

CPC分类号： C01C1/24 ,  C01D1/04 ,  C01F5/14 ,  C01F11/02 ,  C07C51/02 ,  C12P7/46 ,  C12P7/48 ,  C07C55/02 ,  C07C55/06 ,  C07C55/10 ,  C07C55/22 ,  C07C57/13 ,  C07C57/15

公开(公告)号：EP2710117B1

公开(公告)日：2016-04-27

申请号：EP13743087.2

申请日：2013-01-31

申请人： Lanzatech New Zealand Limited

发明人： KOEPKE, Michael ,  NAGARAJU, Shilpa ,  CHEN, Wendy

IPC分类号： C12N1/21 ,  C12N15/52 ,  C12N15/53 ,  C12N15/74 ,  C12P7/06 ,  C12P7/40

CPC分类号： C12P7/065 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/88 ,  C12N15/00 ,  C12N15/52 ,  C12N15/74 ,  C12N2510/02 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/50 ,  C12P7/56 ,  C12P13/06 ,  C12P13/08 ,  C12Y101/01004 ,  C12Y202/01006 ,  C12Y401/01005 ,  Y02E50/17

公开(公告)号：EP2841583B1

公开(公告)日：2016-04-06

申请号：EP13720846.8

申请日：2013-04-24

申请人： PURAC Biochem BV

发明人： VAN KRIEKEN,, Jan ,  KON,, Adriaan Dirk ,  DE HAAN,, André Banier ,  KOOL,, Frederik Gerrit Jan

IPC分类号： C12P7/40 ,  C12P7/44 ,  C12P7/46 ,  C12P7/50 ,  C12P7/56 ,  B01D21/26

CPC分类号： C12P7/56 ,  B01D21/267 ,  C12P7/44 ,  C12P7/46 ,  C12P7/48 ,  C12P7/50 ,  C12P7/52 ,  Y02P20/582

公开(公告)号：EP2276848B1

公开(公告)日：2014-12-17

申请号：EP09739766.5

申请日：2009-04-30

申请人： Danisco US Inc.

发明人： DUAN, Gang ,  RUAN, Zhenhua ,  SHETTY, Jayarama, K. ,  XU, Hongxian

IPC分类号： C12P19/02 ,  C12P7/06 ,  C12P19/18

CPC分类号： C12P13/04 ,  C12P7/06 ,  C12P7/42 ,  C12P7/48 ,  C12P19/14 ,  C12P19/18 ,  Y02E50/17

公开(公告)号：EP2809790A2

公开(公告)日：2014-12-10

申请号：EP13743122.7

申请日：2013-01-31

申请人： Matrix Genetics, LLC

发明人： HICKMAN, Jason, W. ,  ROBERTS, James ,  KOTOVIC, Kimberly, Marie ,  MILLER, Cameron ,  CARLETON, Michael ,  BUDDE, Mark ,  CROSS, Fred ,  KAISER, Brett, K. ,  WARRENER, Paul

IPC分类号： C12P7/64

CPC分类号： C12N15/74 ,  C12N1/38 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/90 ,  C12P5/02 ,  C12P7/04 ,  C12P7/16 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/48 ,  C12P7/50 ,  C12P7/52 ,  C12P7/64 ,  C12P7/6409 ,  C12P7/6445 ,  C12P7/649 ,  C12P9/00 ,  C12P13/001 ,  C12P19/02 ,  C12P21/02 ,  Y02E50/10 ,  Y02E50/13

摘要： The present invention relates to a continuous production system for producing carbon-containing compounds, comprising a genetically modified photosynthetic microorganism, such as a Cyanobacterium, that contains one or more mutations or deletions in a glycogen biosynthesis or storage pathway. The system and methods provided herein facilitate the production of carbon-containing compounds under reduced growth conditions, including biofuels, lipids, and other specialty chemicals, such as fatty acids, alkanes, alkenes, wax esters, and triglycerides.

公开(公告)号：EP2766476A1

公开(公告)日：2014-08-20

申请号：EP12775472.9

申请日：2012-10-11

申请人： Novozymes A/S

发明人： FRIIS, Esben Peter ,  DE MARIA, Leonardo ,  VIND, Jesper ,  POULSEN, Thomas A. ,  SVENDSEN, Allan ,  DANIELSEN, Steffen ,  LENHARD, Rolf T. ,  FRIIS-MADSEN, Henrik ,  SKOV, Lars K.

IPC分类号： C12N9/24

CPC分类号： C12N9/2428 ,  C12N9/242 ,  C12P5/002 ,  C12P5/02 ,  C12P7/06 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P13/20 ,  C12P19/20 ,  C12P37/00 ,  C12Y302/01001 ,  C12Y302/01003 ,  Y02E50/17

摘要： The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

公开(公告)号：EP2748187A1

公开(公告)日：2014-07-02

申请号：EP12825090.9

申请日：2012-07-13

申请人： Codexis, Inc.

发明人： BAIDYAROY, Dipnath ,  CLARK, Louis ,  ELGART, David ,  VOLADRI, Rama ,  ZHANG, Xiyun

IPC分类号： C07K14/37 ,  C12P7/10 ,  C12N15/55 ,  C07H1/00

CPC分类号： C12N9/2437 ,  C12N15/80 ,  C12P7/14 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P7/58 ,  C12P13/14 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01091 ,  Y02E50/16

摘要： The present invention relates to cellobiohydrolase variants having improved thermostability in comparison to wild-type CBH2a.

摘要翻译： 本发明涉及与野生型CBH2a相比具有改善的热稳定性的纤维二糖水解酶变体。

公开(公告)号：EP2739729A1

公开(公告)日：2014-06-11

申请号：EP12741015.7

申请日：2012-08-02

申请人： DSM IP Assets B.V.

发明人： KLAASSEN, Paul ,  DE JONG, René Marcel ,  VAN SUYLEKOM, Gijsberdina Pieternella

IPC分类号： C12N9/92 ,  C12P7/10 ,  C12N15/52

CPC分类号： C12N15/81 ,  C12N9/92 ,  C12N15/815 ,  C12P5/026 ,  C12P7/06 ,  C12P7/10 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P35/00 ,  C12Y503/01005 ,  Y02E50/16 ,  Y02E50/17

摘要： The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

摘要翻译： 本发明涉及包含编码木糖异构酶的核苷酸序列的细胞，其中所述木糖异构酶的氨基酸序列与SEQ ID NO：2所示的氨基酸序列具有至少75％的序列同一性，并且其中所述核苷酸序列 与宿主异源。 本发明的细胞可以用于生产发酵产物如乙醇的方法。 这样的方法可以包括用本发明的细胞发酵含有木糖来源的培养基，使得细胞向发酵产物发酵木糖。

公开(公告)号：EP2710117A4

公开(公告)日：2014-04-16

申请号：EP13743087

申请日：2013-01-31

申请人： LANZATECH NEW ZEALAND LTD

发明人： KOEPKE MICHAEL ,  NAGARAJU SHILPA ,  CHEN WENDY

IPC分类号： C12N1/21 ,  C12N15/52 ,  C12N15/53 ,  C12N15/74 ,  C12P7/06 ,  C12P7/40

CPC分类号： C12P7/065 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/88 ,  C12N15/00 ,  C12N15/52 ,  C12N15/74 ,  C12N2510/02 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/50 ,  C12P7/56 ,  C12P13/06 ,  C12P13/08 ,  C12Y101/01004 ,  C12Y202/01006 ,  C12Y401/01005 ,  Y02E50/17