公开(公告)号：EP2576428A2

公开(公告)日：2013-04-10

申请号：EP11725674.3

申请日：2011-06-06

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  California Institute of Technology

发明人： ERNST, Thomas ,  ANDREUCCI, Philippe ,  COLINET, Eric ,  DURAFFOURG, Laurent ,  MYERS, Edward B. ,  ROUKES, Michael, L.

IPC分类号： B81B7/04 ,  G01N29/02 ,  B81B7/00

CPC分类号： G06F17/00 ,  B81B2201/06 ,  B81C1/00238 ,  B81C2203/0771 ,  B81C2203/0792 ,  G01N30/6095 ,  G01N2291/0256 ,  Y10T29/49117

摘要： A device for analyzing a fluid, including a layer (II) provided with a plurality of sensors (2) of the MEMS and/or NEMS type, a layer (I) including means (4) for controlling the detectors and for processing information transmitted by the detectors (2), said control and processing means (4) being electrically connected to the detectors (2), and a layer (IV) positioned on the layer (II) provided with the sensors on the side of the face including the sensors (2) including means for spatially and temporally distributing said fluid on said sensors (2).

公开(公告)号：EP2480880B1

公开(公告)日：2014-03-19

申请号：EP10785510.8

申请日：2010-09-24

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  California Institute of Technology

发明人： DELAPIERRE, Guillaume ,  HOU-BROUTIN, Yanxia ,  MCCAIG, Heather ,  MYERS, Edward ,  ROUKES, Michael, L.

IPC分类号： G01N29/036 ,  G01N29/02

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

公开(公告)号：EP2577288B1

公开(公告)日：2013-11-20

申请号：EP11724416.0

申请日：2011-06-06

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  California Institute of Technology

发明人： PUGET, Pierre ,  MYERS, Edward B. ,  ROUKES, Michael, L.

IPC分类号： G01N30/60 ,  G01N30/78

CPC分类号： G01N30/78 ,  G01N30/463 ,  G01N30/60 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/8693

摘要： A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.

摘要翻译： 一种用于分析气体混合物的系统，该系统包括至少一个色谱柱，将该混合物注入该柱的机构以及检测形成该气体混合物的化合物的机构，该检测机构包括至少一个纳米传感器类型的检测器， 柱的出口和柱中纳米传感器类型的检测器，能够检测化合物的通过。 然后可以确定系统内每种化合物的速度。

公开(公告)号：EP2577288A1

公开(公告)日：2013-04-10

申请号：EP11724416.0

申请日：2011-06-06

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  California Institute of Technology

发明人： PUGET, Pierre ,  MYERS, Edward B. ,  ROUKES, Michael, L.

IPC分类号： G01N30/60 ,  G01N30/78

CPC分类号： G01N30/78 ,  G01N30/463 ,  G01N30/60 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/8693

摘要： A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system.

公开(公告)号：EP2480880A2

公开(公告)日：2012-08-01

申请号：EP10785510.8

申请日：2010-09-24

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  California Institute of Technology

发明人： DELAPIERRE, Guillaume ,  HOU-BROUTIN, Yanxia ,  MCCAIG, Heather ,  MYERS, Edward ,  ROUKES, Michael, L.

IPC分类号： G01N33/00 ,  G01N29/02

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426

摘要： The present invention concerns a device for detecting gases and/or volatile organic compounds (VOC) comprising at least one electrically conducting and /or semiconducting zone functionalized with at least an organic film resulting from the polymerization of at least one aromatic diazonium salt derived monomer corresponding to the following formula: m((R)nAr-N
2 +) Xm
- (I) A process for the preparation of such a device, and a process for detecting gases and/ or volatile organic compounds (VOC) are also parts of the invention.

公开(公告)号：EP1502279A2

公开(公告)日：2005-02-02

申请号：EP03731110.7

申请日：2003-05-07

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMON, Jerry, E. ,  CROSS, Michael, C. ,  ARLETT, Jessica, L.

IPC分类号： H01J37/26 ,  G01B5/28

CPC分类号： G01N33/54373

摘要： A bioNEMS device is disclosed comprising a BioNEMS cantilever (10) coupled to a constriction region (12) comprising a plurality of legs (20) such that the device operates in fluid and is used to investigate ligand properties using receptors implanted on the cantilever assembly.

公开(公告)号：EP3248210A1

公开(公告)日：2017-11-29

申请号：EP16704732.3

申请日：2016-01-22

申请人： California Institute of Technology ,  Thermo Fisher Scientific (Bremen) GmbH

发明人： ROUKES, Michael, L. ,  MAKAROV, Alexander, A.

IPC分类号： H01J49/06 ,  H01J49/26

CPC分类号： H01J49/0013 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/06 ,  H01J49/061 ,  H01J49/26 ,  H01J49/425

摘要： A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an integration zone coupling the first and second mass spectral systems, the integration zone including at least one directional device for controllably routing the ions to a selected one or both of the first and second mass spectral systems for analysis thereby. The second system can be an orbital electrostatic trap system. The ion beam can be electrically directed to one or the other system by ion optics. A chip with resonators can be used with cooling. Uses include analysis of large mass complexes found in biological systems, native single molecule analysis, and size and shape analysis.

公开(公告)号：EP1325302B1

公开(公告)日：2006-10-11

申请号：EP01964587.8

申请日：2001-08-09

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： ROUKES, Michael, L. ,  FRASER, Scott, E. ,  SOLOMAN,Jerry E. ,  CROSS,Michael C.

IPC分类号： B81B7/02 ,  G01N33/543 ,  B81B3/00

CPC分类号： G01N29/036 ,  B82Y5/00 ,  B82Y35/00 ,  G01N33/54373 ,  G01N2291/0257

摘要： A biofunctionalized nanoelectromechanical device (BioNEWS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEWS device during a binding event is provided. The biofunctionalized nanoelctromechanical device according to the invention generally comprises a nanomechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the machanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalzed nanoelectromechanical devices and a method for utilizing the biofunctionalized nanelectromechanical device of the present invention are also provided.

公开(公告)号：EP1390287A2

公开(公告)日：2004-02-25

申请号：EP02741690.8

申请日：2002-05-03

申请人： California Institute Of Technology

发明人： ROUKES, Michael, L. ,  EKINCI, Kamil, L.

IPC分类号： B81C1/00

CPC分类号： G01N29/036 ,  G01G3/16 ,  G01N2291/0256 ,  H01J49/26

摘要： The invention relates to the application of the techniques of nanoelectromechanical system (NEMS) to ultrasensitive mass detection. A pulsed flux of atoms is adsorbed onto the surface of a 32.8 MHz nanomechanical resonator (10) within an ultrahigh vacuum environment. The mass-induced frequency shifts from these adsorbates are then used to demonstrate a mass sensitivity of ∩1.46x106 Daltons (Da). For resonators (10) operating up to frequencies of 72 MHz, inverse mass responsivities as small as ∩8x10-20 grams/Hz (5x104 Da/Hz) are obtained. Our results offer a new approach to ultrahigh resolution mass spectrometry of individual, electrically-neutral macromolecules with clear prospects for single Dalton sensitivity.

公开(公告)号：EP1749185A2

公开(公告)日：2007-02-07

申请号：EP05736813.6

申请日：2005-04-15

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： TANG, Hongxing ,  LI, Mo ,  ROUKES, Michael, L.

IPC分类号： G01B5/28

CPC分类号： G01Q60/38 ,  G01Q20/04

摘要： Thin metallic films are used as the piezoresistive self-sensing element in microelectromechanical and nanoelectromechanical systems. The specific application to AFM probes is demonstrated.