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1.发明公开IFI206, A NOVEL INTERFERON-INDUCED POLYPEPTIDE, AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开IFI206，小说，干扰素诱导多肽，为此编码核酸
公开(公告)号：EP1282696A1
公开(公告)日：2003-02-12
申请号：EP01918720.2
申请日：2001-03-13
发明人： LEWIN, David, A. , ADAMS, Sean
IPC分类号： C12N15/00 , C12N15/12 , C12N15/20 , C07K14/435 , C07K14/455 , A61K38/17 , A61K38/21
摘要： The present invention provides novel mouse interferon-inducible proteins (IFI206 and naturally occuring variants) modulated under conditions that affect metabolic status and the polynucleotides that identify and encode IFI206. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IFI206 and for a method for producing the protein. The invention also provides pharmaceutical compositions containing IFI206 and the use of such compositions for the prevention or treatment of diseases associated with the expression of IFI206. Additionally, the invention provides antisense molecules to IFI206 and their use in the treatment of diseases associated with the expression of IFI206. The invention also provides diagnostic assays that utilize polynucleotides that hybridize with naturally occurring sequences encoding IFI206 and antibodies that specifically bind to the protein.
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2.发明公开CONTROL OF METABOLISM WITH COMPOSITIONS OF THE HUMAN 2-OXOGLUTARATE CARRIER 有权代谢控制借助人居在一起，2-酮戊二酸的载体
公开(公告)号：EP1294881A2
公开(公告)日：2003-03-26
申请号：EP01950401.8
申请日：2001-06-22
申请人： GENENTECH, INC.
发明人： ADAMS, Sean , YU, Xing Xian
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00 , C07K2319/43 , C12Q1/6809 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5079 , G01N2800/52
摘要： The present invention is directed to compositions and methods related to the use of human OGC as an uncoupling protein.
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3.发明授权CONTROL OF METABOLISM WITH COMPOSITIONS OF THE HUMAN 2-OXOGLUTARATE CARRIER 有权代谢控制借助人居在一起，2-酮戊二酸的载体
公开(公告)号：EP1294881B1
公开(公告)日：2004-09-15
申请号：EP01950401.8
申请日：2001-06-22
申请人： GENENTECH, INC.
发明人： ADAMS, Sean , YU, Xing Xian
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00 , C07K2319/43 , C12Q1/6809 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5079 , G01N2800/52
摘要： The present invention is directed to compositions and methods related to the use of human OGC as an uncoupling protein.
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公开(公告)号：EP1135496B1
公开(公告)日：2010-12-22
申请号：EP99973036.9
申请日：1999-11-03
申请人： Genentech, Inc.
发明人： ADAMS, Sean , PAN, James
IPC分类号： C12N15/12 , C12N15/70 , C12N15/81 , C12N15/85 , C12N5/10 , C12N1/19 , C07K14/47 , C07K16/18 , C12P21/02 , A61K38/17 , G01N33/53
CPC分类号： C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ('UCPs') and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1135496A2
公开(公告)日：2001-09-26
申请号：EP99973036.9
申请日：1999-11-03
申请人： Genentech, Inc.
发明人： ADAMS, Sean , PAN, James
IPC分类号： C12N15/12 , C12N15/70 , C12N15/81 , C12N15/85 , C12N5/10 , C12N1/19 , C07K14/47 , C07K16/18 , C12P21/02 , A61K38/17 , G01N33/53
CPC分类号： C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ('UCPs') and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与某些人解偶联蛋白质（“UCPs”）具有同源性的新多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体和用于产生本发明多肽的方法 发明。
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公开(公告)号：EP1115863B1
公开(公告)日：2007-11-28
申请号：EP99969439.1
申请日：1999-09-15
申请人： GENENTECH, INC.
发明人： ADAMS, Sean , PAN, James , ZHONG, Alan
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ("UCPs") and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与某些人解偶联蛋白质（“UCP”）具有同源性的新多肽以及编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体和用于产生本发明多肽的方法 发明。
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公开(公告)号：EP1115863A1
公开(公告)日：2001-07-18
申请号：EP99969439.1
申请日：1999-09-15
申请人： Genentech, Inc.
发明人： ADAMS, Sean , PAN, James , ZHONG, Alan
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins ('UCPs') and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及与某些人解偶联蛋白质（“UCPs”）具有同源性的新多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体和用于产生本发明多肽的方法 发明。
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