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22 条记录 (耗时 0.026 秒)

    COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG CANCERS (NSCLC)
    1.
    发明公开
    COMPOSITION FOR TREATING LUNG CANCER, PARTICULARLY OF NON-SMALL LUNG CANCERS (NSCLC) 有权
    组成肺癌的治疗，尤其是NSCLC

    公开(公告)号：EP2197481A2

    公开(公告)日：2010-06-23

    申请号：EP08838033.2

    申请日：2008-10-08

    申请人： CureVac GmbH

    发明人： BARNER, Marijke ,  PROBST, Jochen ,  LANDER, Thomas ,  HOERR, Ingmar

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0011 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70

    摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.

    摘要翻译： 本发明涉及到活性（免疫刺激）组合物包含至少一种RNA，优选mRNA的一个，编码至少两种（优选不同的）抗原能够在（自适应）在哺乳动物的免疫应答引发的。 本发明进一步更涉及一种疫苗，其包含所述活性（免疫刺激）组合物，以及使用所述活性（免疫刺激）组合物（用于疫苗的制备）和/或疫苗的在（自适应），用于免疫应答引发 治疗肺癌，特别是非小细胞肺癌（NSCLC），优选三个主要的子类型鳞状细胞肺癌，腺癌和大细胞肺癌，或与其相关的病症组成的组。 最后，本发明涉及试剂盒，特别是零件的试剂盒，含有活性（免疫刺激）组合物和/或疫苗。

    COMPOSITION FOR TREATING PROSTATE CANCER (PCa)
    9.
    发明公开
    COMPOSITION FOR TREATING PROSTATE CANCER (PCa) 有权
    成分对前列腺癌的治疗（PCA）

    公开(公告)号：EP2195015A1

    公开(公告)日：2010-06-16

    申请号：EP08802829.5

    申请日：2008-10-08

    申请人： Curevac GmbH

    发明人： PROBST, Jochen ,  HOERR, Ingmar ,  LANDER, Thomas

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70

    摘要： The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate- Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.