公开(公告)号：EP1853711A2

公开(公告)日：2007-11-14

申请号：EP06736787.0

申请日：2006-03-02

申请人： Dow AgroSciences LLC

发明人： LARRINUA, Ignacio, M. ,  MERLO, Donald, J. ,  WOOSLEY, Aaron, Todd ,  HEY, Timothy, D. ,  MEADE, Thomas ,  BURTON, Stephanie, Love

IPC分类号： C12N15/82 ,  C07K14/195 ,  C07K14/37

CPC分类号： C07K14/195 ,  A01N63/00 ,  A01N63/04 ,  C07K14/20 ,  C07K14/21 ,  C07K14/37 ,  C07K16/14 ,  C07K2319/00 ,  Y10S530/858

摘要： The subject invention provides exciting new sources for surprising, new types of toxin complex ('TC') proteins. The subject invention includes these new classes and types of TC proteins. The subject invention also includes polynucleotides that encode the subject proteins. The subject invention further provides vectors and cells comprising these polynucleotides. The subject invention also provides novel methods of controlling insects. The subject invention relates in part to the surprising discovery that new types of TC proteins can be obtained from a widely diverse phylogenetic spectrum of organisms including, most notably and surprisingly, eukaryotic fungus.

公开(公告)号：EP2560475A1

公开(公告)日：2013-02-27

申请号：EP11772785.9

申请日：2011-04-22

申请人： Dow AgroSciences, LLC

发明人： NARVA, Kenneth, E. ,  MEADE, Thomas ,  FENCIL, Kristin, J. ,  LI, Huarong ,  HEY, Timothy, D. ,  WOOSLEY, Aaron, T. ,  OLSON, Monica, Britt

IPC分类号： A01H5/00 ,  C12N5/04 ,  A01N37/18

CPC分类号： C12N15/8286 ,  A01G22/00 ,  A01H5/10 ,  A01N37/18 ,  A01N43/50 ,  B32B1/02 ,  B65D85/00 ,  C07K14/325 ,  Y02A40/162 ,  Y10T428/13

摘要： The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins "triple stacked" with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.

摘要翻译： 本主题发明涉及在与Cry6Aa组合部分Cry34Ab / 35AB。 本主题发明部分地涉及令人惊讶的发现所做Cry34Ab / Cry35Ab和Cry6Aa的组合是用于由玉米根虫防治耐药性的发展（单独的任一杀昆虫蛋白系统）有用（叶甲属）种群。 包括在本发明中是植物生产合成杀虫Cry蛋白，这些都是减轻的关注做了一个玉米根虫群可以发展做了单独会是要么耐合成杀虫蛋白系统是有用的。 植物（和种植面积与检查植物）确实产生合成2个杀虫蛋白系统都包括在本发明的范围之内。 本主题发明部分因此涉及具有Cry6Aa蛋白Cry34Ab / 35AB和的Cry3Aa蛋白的结合“三层堆叠”。 转基因植物，包括玉米，包括cry6Aa基因，cry34Ab / 35AB基因，以及基因的Cry3Aa被包括在本发明的范围之内。 因此，调查了实施例中的目标用行动的三种模式根虫。

公开(公告)号：EP1234045A2

公开(公告)日：2002-08-28

申请号：EP00982321.2

申请日：2000-12-01

申请人： Dow AgroSciences LLC

发明人： ARMSTRONG, Katherine ,  HEY, Timothy, D. ,  FOLKERTS, Otto ,  SMITH, Kelley, A. ,  HOPKINS, Nicole, L.

IPC分类号： C12N15/82 ,  A01H5/00 ,  A01H5/10

CPC分类号： C12N15/8222 ,  C12N9/90 ,  C12N15/8234

摘要： The maize myo-inositol-1-phosphate synthase (MIP synthase) gene and novel embryo specific regulatory sequences derived from the MIP synthase gene are useful in plant genetic engineering.

公开(公告)号：EP2560478B1

公开(公告)日：2018-02-14

申请号：EP11772790.9

申请日：2011-04-22

申请人： Dow AgroSciences, LLC

发明人： NARVA, Kenneth, E. ,  MEADE, Thomas ,  FENCIL, Kristin, J. ,  LI, Huarong ,  HEY, Timothy, D. ,  WOOSLEY, Aaron, T. ,  OLSON,Monica, Britt

IPC分类号： A01H5/00 ,  A01H5/10 ,  C12N5/04 ,  A01N63/02 ,  C12N15/82

CPC分类号： C12N15/8286 ,  A01G22/00 ,  A01H5/10 ,  A01N37/18 ,  A01N43/50 ,  B32B1/02 ,  B65D85/00 ,  C07K14/325 ,  Y02A40/162 ,  Y10T428/13

摘要： The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins "triple stacked" with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.

公开(公告)号：EP2560478A1

公开(公告)日：2013-02-27

申请号：EP11772790.9

申请日：2011-04-22

申请人： Dow AgroSciences, LLC

发明人： NARVA, Kenneth, E. ,  MEADE, Thomas ,  FENCIL, Kristin, J. ,  LI, Huarong ,  HEY, Timothy, D. ,  WOOSLEY, Aaron, T. ,  OLSON,Monica, Britt

IPC分类号： A01H5/00 ,  C12N5/04 ,  A01N37/18

CPC分类号： C12N15/8286 ,  A01G22/00 ,  A01H5/10 ,  A01N37/18 ,  A01N43/50 ,  B32B1/02 ,  B65D85/00 ,  C07K14/325 ,  Y02A40/162 ,  Y10T428/13

摘要： The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins "triple stacked" with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.

摘要翻译： 本主题发明涉及在与Cry6Aa组合部分Cry34Ab / 35AB。 本主题发明部分地涉及令人惊讶的发现所做Cry34Ab / Cry35Ab和Cry6Aa的组合是用于由玉米根虫防治耐药性的发展（单独的任一杀昆虫蛋白系统）有用（叶甲属）种群。 包括在本发明中是植物生产合成杀虫Cry蛋白，这些都是减轻的关注做了一个玉米根虫群可以发展做了单独会是要么耐合成杀虫蛋白系统是有用的。 植物（和种植面积与检查植物）确实产生合成2个杀虫蛋白系统都包括在本发明的范围之内。 本主题发明部分因此涉及具有Cry6Aa蛋白Cry34Ab / 35AB和的Cry3Aa蛋白的结合“三层堆叠”。 转基因植物，包括玉米，包括cry6Aa基因，cry34Ab / 35AB基因，以及基因的Cry3Aa被包括在本发明的范围之内。 因此，调查了实施例中的目标用行动的三种模式根虫。

公开(公告)号：EP2560477A1

公开(公告)日：2013-02-27

申请号：EP11772789.1

申请日：2011-04-22

申请人： Dow AgroSciences, LLC

发明人： NARVA, Kenneth, E. ,  MEADE, Thomas ,  FENCIL, Kristin, J. ,  LI, Huarong ,  HEY, Timothy, D. ,  WOOSLEY, Aaron, T. ,  OLSON, Monica, Britt

IPC分类号： A01H5/00 ,  C12N5/02

CPC分类号： C12N15/8286 ,  A01G22/00 ,  A01H5/10 ,  A01N37/18 ,  A01N43/50 ,  B32B1/02 ,  B65D85/00 ,  C07K14/325 ,  Y02A40/162 ,  Y10T428/13

摘要： The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins "triple stacked" with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.

摘要翻译： 本发明部分涉及与Cry6Aa组合的Cry34Ab / 35Ab。 本发明部分涉及令人惊讶的发现，即Cry34Ab / Cry35Ab和Cry6Aa的组合可用于预防玉米根虫（Diabrotica spp。）种群对抗（单独针对杀虫蛋白系统）的抗性发展。 包括在本发明中的是产生这些杀虫Cry蛋白的植物，其可用于减轻玉米根虫群体可能发展的对单独对这些杀虫蛋白系统中的任一个有抗性的担忧。 产生这两种杀虫蛋白质系统的植物（和种植这些植物的种植面积）包括在本发明的范围内。 本发明还部分涉及Cry3Ab / 35Ab和Cry3Aa蛋白与Cry6Aa蛋白“三重堆叠”的组合。 包含cry6Aa基因，cry34Ab / 35Ab基因和cry3Aa基因的转基因植物，包括玉米，包括在本发明的范围内。 因此，这些实施方案以三种作用模式针对根虫。

公开(公告)号：EP2560476A1

公开(公告)日：2013-02-27

申请号：EP11772786.7

申请日：2011-04-22

申请人： Dow AgroSciences, LLC

发明人： NARVA, Kenneth, E. ,  MEADE, Thomas ,  FENCIL, Kristin, J. ,  LI, Huarong ,  HEY, Timothy, D. ,  WOOSLEY, Aaron, T. ,  OLSON, Monica, Britt

IPC分类号： A01H5/00 ,  C12N5/04 ,  A01N37/18

CPC分类号： C12N15/8286 ,  A01G22/00 ,  A01H5/10 ,  A01N37/18 ,  A01N43/50 ,  B32B1/02 ,  B65D85/00 ,  C07K14/325 ,  Y02A40/162 ,  Y10T428/13

摘要： The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins "triple stacked" with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.

摘要翻译： 本发明部分涉及与Cry3Ba组合的Cry34Ab / 35Ab。 本发明部分涉及令人惊讶的发现，即Cry34Ab / Cry35Ab和Cry3Ba可用于防止玉米根虫（Diabrotica spp。）群体产生抗性（单独针对任一种杀虫蛋白系统）的发展。 如本领域技术人员从本公开内容的益处将认识到的，产生这些杀虫Cry蛋白的植物将有助于减轻对单独对这些杀虫蛋白系统中的任一个有抗性的玉米根虫群体可能发育的担忧。 本发明部分得到以下发现的支持：这些Cry蛋白系统的组分不会彼此竞争结合玉米根虫肠道受体。 本发明还部分涉及三种（或多种）毒素系统的三重叠层或“金字塔”，其中Cry34Ab / Cry35Ab和Cry3Ba是碱基对。 因此，产生这两种杀虫蛋白质系统的植物（和种植有这种植物的种植面积）包括在本发明的范围内。

公开(公告)号：EP1234045B1

公开(公告)日：2010-09-22

申请号：EP00982321.2

申请日：2000-12-01

申请人： Dow AgroSciences LLC

发明人： ARMSTRONG, Katherine ,  HEY, Timothy, D. ,  FOLKERTS, Otto ,  SMITH, Kelley, A. ,  HOPKINS, Nicole, L.

IPC分类号： C12N15/82 ,  A01H5/00 ,  A01H5/10

CPC分类号： C12N15/8222 ,  C12N9/90 ,  C12N15/8234

摘要： The maize myo-inositol-1-phosphate synthase (MIP synthase) gene and novel embryo specific regulatory sequences derived from the MIP synthase gene are useful in plant genetic engineering.

公开(公告)号：EP1706491A2

公开(公告)日：2006-10-04

申请号：EP04815116.1

申请日：2004-12-23

申请人： Dow AgroSciences LLC

发明人： APEL-BIRKHOLD, Patricia, C. ,  HEY, Timothy, D. ,  SHEETS, Joel, J. ,  MEADE, Thomas ,  LI, Ze, Sheng ,  LIRA, Justin, M. ,  RUSSELL, Sean, M. ,  THOMPSON, Robin, L. ,  MITCHELL, Jon, C. ,  FENCIL, Kristin

IPC分类号： C12N15/31 ,  C12N15/32 ,  C12N15/00 ,  C12N15/03 ,  C12N15/05 ,  C12N15/08 ,  C12N15/10 ,  C12P21/02

CPC分类号： C12N15/8286 ,  A01N63/00 ,  A01N63/02 ,  C07H21/04 ,  C07K14/24 ,  C12N15/8279 ,  Y02A40/162 ,  Y10S530/825

摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins encoded by genes from Xenorhabdus bovienii strain ILM 104, and methods of controlling an insect with the toxin proteins.

公开(公告)号：EP2560475B1

公开(公告)日：2018-02-14

申请号：EP11772785.9

申请日：2011-04-22

申请人： Dow AgroSciences LLC

发明人： NARVA, Kenneth, E. ,  MEADE, Thomas ,  FENCIL, Kristin, J. ,  LI, Huarong ,  HEY, Timothy, D. ,  WOOSLEY, Aaron, T. ,  OLSON, Monica, Britt

IPC分类号： A01H5/00 ,  A01H5/10 ,  C12N5/04 ,  A01N63/02 ,  C12N15/82

CPC分类号： C12N15/8286 ,  A01G22/00 ,  A01H5/10 ,  A01N37/18 ,  A01N43/50 ,  B32B1/02 ,  B65D85/00 ,  C07K14/325 ,  Y02A40/162 ,  Y10T428/13

摘要： The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm (Diabrotica spp.) population. Included within the subject invention are plants producing these insecticidal Cry proteins, which are useful to mitigate concern that a corn rootworm population could develop that would be resistant to either of these insecticidal protein systems alone. Plants (and acreage planted with such plants) that produce these two insecticidal protein systems are included within the scope of the subject invention. The subject invention also relates in part to combinations of Cry34Ab/35Ab and Cry3Aa proteins "triple stacked" with a Cry6Aa protein. Transgenic plants, including corn, comprising a cry6Aa gene, cry34Ab/35Ab genes, and a cry3Aa gene are included within the scope of the subject invention. Thus, such embodiments target rootworms with three modes of action.