公开(公告)号：EP1069897A1

公开(公告)日：2001-01-24

申请号：EP99916334.8

申请日：1999-04-07

Applicant: ELI LILLY AND COMPANY

Inventor： GRUBER, Joseph, Michael ,  NORMAN, Bryan, H.

IPC: A61K31/44 ,  C07D498/02

CPC classification number: C07D498/04 ,  A61K31/4745

Abstract: The present invention relates to a compound of formula (I) which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

公开(公告)号：EP1067932A1

公开(公告)日：2001-01-17

申请号：EP99917359.4

申请日：1999-04-07

Applicant: ELI LILLY AND COMPANY

Inventor： GRUBER, Joseph, Michael ,  HOLLINSHEAD, Sean, Patrick ,  NORMAN, Bryan, Hurst ,  WILSON, Joseph, Wendell

IPC: A61K31/47 ,  C07D498/04

CPC classification number: C07D498/04

Abstract: The present invention relates to a compound of formula (I) which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

Abstract translation: 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性肿瘤。

公开(公告)号：EP1250340B1

公开(公告)日：2004-11-17

申请号：EP00986242.6

申请日：2000-12-11

Applicant: ELI LILLY AND COMPANY

Inventor： BONJOUKLIAN, Rosanne ,  COHEN, Jeffrey, Daniel ,  GRUBER, Joseph, Michael ,  JOHNSON, Douglas, Webb ,  JUNGHEIM, Louis, Nickolaus ,  KROIN, Julian, Stanley ,  LANDER, Peter, Ambrose ,  LIN, Ho-Shen ,  LOHMAN, Mark, Christopher ,  MUEHL, Brian, Stephen ,  NORMAN, Bryan, Hurst ,  PATEL, Vinod, Francis ,  RICHETT, Michael, Enrico ,  THRASHER, Kenneth, Jeff ,  VEPACHEDU, Sreenivasarao ,  WHITE, Wesley, Todd ,  XIE, Yongping ,  YORK, Jeremy Schulenburg ,  PARKHURST, Brandon, Lee ,  WANG, Quiping

IPC: C07D498/04 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00

CPC classification number: C07D471/04

Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).

公开(公告)号：EP1067928A1

公开(公告)日：2001-01-17

申请号：EP99916456.9

申请日：1999-04-07

Applicant: ELI LILLY AND COMPANY

Inventor： GRUBER, Joseph, Michael ,  KROIN, Julian, Stanley ,  NORMAN, Bryan, Hurst

IPC: A61K31/44 ,  C07D498/02

CPC classification number: A61K31/704 ,  A61K31/475 ,  A61K45/06 ,  C07D498/02 ,  A61K2300/00

Abstract: The present invention relates to a compound of formula (I), which is useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

公开(公告)号：EP1250340A1

公开(公告)日：2002-10-23

申请号：EP00986242.6

申请日：2000-12-11

Applicant: ELI LILLY AND COMPANY ,  Wang, Qiuping

Inventor： BONJOUKLIAN, Rosanne ,  COHEN, Jeffrey, Daniel ,  GRUBER, Joseph, Michael ,  JOHNSON, Douglas, Webb ,  JUNGHEIM, Louis, Nickolaus ,  KROIN, Julian, Stanley ,  LANDER, Peter, Ambrose ,  LIN, Ho-Shen ,  LOHMAN, Mark, Christopher ,  MUEHL, Brian, Stephen ,  NORMAN, Bryan, Hurst ,  PATEL, Vinod, Francis ,  RICHETT, Michael, Enrico ,  THRASHER, Kenneth, Jeff ,  VEPACHEDU, Sreenivasarao ,  WHITE, Wesley, Todd ,  XIE, Yongping ,  YORK, Jeremy Schulenburg ,  PARKHURST, Brandon, Lee ,  WANG, Quiping

IPC: C07D498/04 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00

CPC classification number: C07D471/04

Abstract: The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).

公开(公告)号：EP1077701A1

公开(公告)日：2001-02-28

申请号：EP98923565.0

申请日：1998-05-20

Applicant: ELI LILLY AND COMPANY

Inventor： EZQUERRA-CARRERA, Jesus ,  GRUBER, Joseph, Michael ,  HAMDOUCHI, Chafiq, Hamdouchi ,  HOLMES, Richard, Elmer ,  SPITZER, Wayne, Alfred

IPC: A61K31/44 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of Formula (I), which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. In said Formula, A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF¿3?; X is N-OH, O, or CHR?1; R1¿ is hydrogen, halo, CN, C¿1?-C4 alkyl, -C CH, CO(C1-C4 alkyl), CO2(C1-C4 alkyl), or CONR?2R3; R2 and R3¿ are independently hydrogen or C¿1?-C4 alkyl; A' is hydrogen, halo, C1-C6 alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR?4¿, S(O)¿nR?4, or a group of formula (II); R4 is C1-C6 alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5 is independently at each occurance hydrogen or halo; m is 1, 2, 3, or 4; and R6 is hydrogen, halo, CF¿3?, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4 alkyl, or CO2(C1-C4 alkyl), C1-C4 alkoxy; or pharmaceutically acceptable salts thereof.