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1.发明公开
公开(公告)号：EP1224189A2
公开(公告)日：2002-07-24
申请号：EP00968314.5
申请日：2000-09-22
发明人： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC分类号： C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1385852B1
公开(公告)日：2005-07-20
申请号：EP02719126.1
申请日：2002-03-27
IPC分类号： C07D498/14 , A61K31/44 , A61P35/00
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I) which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1385852A1
公开(公告)日：2004-02-04
申请号：EP02719126.1
申请日：2002-03-27
IPC分类号： C07D498/14 , A61K31/44 , A61P35/00
CPC分类号： C07D498/04
摘要： The present invention relates to a compound of formula (I) which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1250340A1
公开(公告)日：2002-10-23
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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5.发明授权
公开(公告)号：EP1224189B1
公开(公告)日：2006-01-25
申请号：EP00968314.5
申请日：2000-09-22
发明人： BONJOUKLIAN, Rosanne , JOHNSON, Douglas, Webb , LANDER, Peter, Ambrose , LOHMAN, Mark, Christopher , PATEL, Vinod, Francis , VEPACHEDU, Sreenivasarao , XIE, Yongping
IPC分类号： C07D498/04 , C07D471/04 , A61K31/4741 , A61K31/4745 , A61P35/00 , C07D261/00 , C07D221/00 , C07D231/00 , C07D263/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.
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公开(公告)号：EP1250340B1
公开(公告)日：2004-11-17
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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