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    Diphenyl-methane derivative, pharmaceutical composition and use
    2.
    发明公开
    Diphenyl-methane derivative, pharmaceutical composition and use 失效
    二苯甲烷衍生物，药物组合物和用途

    公开(公告)号：EP0479332A3

    公开(公告)日：1992-04-15

    申请号：EP91119344.9

    申请日：1987-03-17

    申请人： Eisai Co., Ltd.

    发明人： Yamagishi, Youji ,  Akasaka, Kozo ,  Suzuki, Takeshi ,  Miyamato, Mitsuaki ,  Nakamoto, Kouji ,  Okano, Kazuo ,  Abe, Shinya ,  Ikuta, Hironori ,  Hayashi, Kenji ,  Yoshimura, Hiroyuki ,  Fujimori, Tohru ,  Harada, Koukichi ,  Yamatsu, Isao

    IPC分类号： C07C235/34 ,  C07C311/17 ,  C07C257/14 ,  A61K31/15 ,  A61K31/18 ,  A61K31/275 ,  C07C235/38 ,  C07C257/06 ,  C07C69/618 ,  C07C57/42

    CPC分类号： C07D257/04 ,  C07C59/64 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D339/08

    摘要： A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative.
    in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is = CXY or = N-O-W, X is hydrogen, cyano or -COR6, R6 being hydroxyl or an amino, Y is -R10-COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, -CO-NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, -CH2-NHS02-C6H5 or -C(R8) = NR7, R7 being a lower alkoxy or an aryl, R8 is -VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl, W is -CH2-CO-CH2-COOR13, R13 being hydrogen or a lower alkyl, -CH2-C(=NOR14)-CH2-COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, -CH(CN)-(CH2)q-COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or -(CH2)p-Z, Z being -SH, -SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2. A pharmaceutical composition containing compounds of formula (XX) or their pharmaceutically acceptable salts as active ingredients, and the use of compounds of formula (XX) or their pharmaceutically acceptable salts in the preparation of a medicament for treatment of diseases caused by blood stream disorders are also disclosed.

    摘要翻译： 新的二苯基甲烷衍生物可用于抑制血液凝聚，并由式（2）定义，包括二苯基乙烯衍生物和二苯甲酮肟醚衍生物。 其中R1和R2各自为氢，羟基或低级烷氧基，U为= CXY或= NOW，X为氢，氰基或-COR6，R6为羟基或氨基，Y为-R10-COOR3，R3为氢或 低级烷氧基，R 10为具有1至3个碳原子的亚烷基，直链或支链的-CO-NR 4 R 5，R 4和R 5各自为氢，低级烷基或低级芳烷基，-CH 2 -NHSO 2 -C 6 H 5或-C（R 8 ）= NR7，R7是低级烷氧基或芳基，R8是-VR9，V是氧，硫或氮，R9是烷基或芳基，W是-CH2-CO-CH2-COOR13，R13是氢或 低级烷基，-CH 2 -C（= NOR 14）-CH 2 -COOR 15，R 15是氢或低级烷基，R 14是低级烷基，-CH（CN） - （CH 2）q -COOR 16，R 16是氢或低级烷基 ，q为1至3的整数，或 - （CH 2）p Z，Z为-SH，-SCN或衍生自可被具有一个或多个硫的环取代的五元或六元环的一价基团 原子在环中，p为1或2.含有式（XX）化合物的药物组合物， 或其药学上可接受的盐作为活性成分，并且还公开了式（XX）的化合物或其药学上可接受的盐在制备用于治疗由血流障碍引起的疾病的药物中的用途。

    Diphenyl-methane derivative, pharmaceutical composition and use
    8.
    发明公开
    Diphenyl-methane derivative, pharmaceutical composition and use 失效
    二苯甲烷衍生物，药物Zusammensetzung und Verwendung。

    公开(公告)号：EP0238973A2

    公开(公告)日：1987-09-30

    申请号：EP87103834.5

    申请日：1987-03-17

    申请人： Eisai Co., Ltd.

    发明人： Yamagishi, Youji ,  Akasaka, Kozo ,  Suzuki, Takeshi ,  Miyamoto, Mitsuaki ,  Nakamoto, Kouji ,  Okano, Kazuo ,  Abe, Shinya ,  Ikuta, Hironori ,  Hayashi, Kenji ,  Yoshimura, Hiroyuki ,  Fujimori, Tohru ,  Harada, Koukichi ,  Yamatsu, Isao

    IPC分类号： C07C251/00 ,  C07C311/15 ,  C07C235/42 ,  C07C255/37 ,  C07C233/65 ,  C07D213/75 ,  C07C257/00 ,  C07C257/06 ,  C07C327/00 ,  C07C59/64 ,  A61K31/15

    CPC分类号： C07D257/04 ,  C07C59/64 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D339/08

    摘要： A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative.
    in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is =CXY or =N-O-W,
    X is hydrogen, cyano or -COR6, R6 being hydroxyl or an amino, Y is -R10-COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, -CO-NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, -CH2-NHSO2-C6H5 or -C(R8)=NR7, R7 being a lower alkoxy or an aryl, R8 is -VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,
    W is -CH2-CO-CH2-C00R13, R13 being hydrogen or a lower alkyl, -CH2-C(=NOR14)-CH2-COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, -CH(CN)-(CH2)q-COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or -(CH2)p-Z, Z being -SH, -SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.
    A pharmaceutical composition containing compounds of formula (XX) or their pharmaceutically acceptable salts as active ingredients, and the use of compounds of for­mula (XX) or their pharmaceutically acceptable salts in the preparation of a medicament for treatment of diseases caused by blood stream disorders are also disclosed.

    摘要翻译： 新的二苯基甲烷衍生物可用于抑制血液凝聚，并由式定义，包括二苯基乙烯衍生物和二苯甲酮肟醚衍生物。 其中R 1和R 2各自为氢，羟基或低级烷氧基，U为= XY =或NOW，X为氢，氰基或-COR 6，R6为羟基或氨基，Y为-R10-COOR3，R3 是氢或低级烷氧基，R10是具有1至3个碳原子的直链或支链的亚烷基，-CO-NR4R5，R4和R5各自为氢，低级烷基或低级芳基烷基，-CH2-NHSO2-C6H5或 - C（R8）= NR7，R7为低级烷氧基或芳基，R8为-VR9，V为氧，硫或氮，R9为烷基或芳基，W为-CH2-CO-CH2-C00R13，R13为 氢或低级烷基，-CH 2 -C（= NOR 14）-CH 2 -COOR 15，R 15为氢或低级烷基，R 14为低级烷基，-CH（CN） - （CH 2）q -COOR 16，R 16为氢或 低级烷基，q为1至3的整数，或 - （CH 2）pZ，Z为-SH，-SCN或衍生自五元或六元环的一价基团，其可被具有一个 或更多的硫原子，p为1或2.含有式（ XX）或其药学上可接受的盐作为活性成分，并且还公开了式（XX）化合物或其药学上可接受的盐在制备用于治疗由血液病症引起的疾病的药物中的用途。

    Diphenyl-methane derivative, pharmaceutical composition and use
    10.
    发明公开
    Diphenyl-methane derivative, pharmaceutical composition and use 失效
    二苯甲烷衍生物，药用植物佐剂和维他命。

    公开(公告)号：EP0479332A2

    公开(公告)日：1992-04-08

    申请号：EP91119344.9

    申请日：1987-03-17

    申请人： Eisai Co., Ltd.

    发明人： Yamagishi, Youji ,  Akasaka, Kozo ,  Suzuki, Takeshi ,  Miyamato, Mitsuaki ,  Nakamoto, Kouji ,  Okano, Kazuo ,  Abe, Shinya ,  Ikuta, Hironori ,  Hayashi, Kenji ,  Yoshimura, Hiroyuki ,  Fujimori, Tohru ,  Harada, Koukichi ,  Yamatsu, Isao

    IPC分类号： C07C235/34 ,  C07C311/17 ,  C07C257/14 ,  A61K31/15 ,  A61K31/18 ,  A61K31/275 ,  C07C235/38 ,  C07C257/06 ,  C07C69/618 ,  C07C57/42

    CPC分类号： C07D257/04 ,  C07C59/64 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D339/08

    摘要： A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative.
    in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is = CXY or = N-O-W,
    X is hydrogen, cyano or -COR6, R6 being hydroxyl or an amino, Y is -R10-COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, -CO-NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, -CH2-NHS02-C6H5 or -C(R8) = NR7, R7 being a lower alkoxy or an aryl, R8 is -VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,
    W is -CH2-CO-CH2-COOR13, R13 being hydrogen or a lower alkyl, -CH2-C(=NOR14)-CH2-COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, -CH(CN)-(CH2)q-COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or -(CH2)p-Z, Z being -SH, -SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.
    A pharmaceutical composition containing compounds of formula (XX) or their pharmaceutically acceptable salts as active ingredients, and the use of compounds of formula (XX) or their pharmaceutically acceptable salts in the preparation of a medicament for treatment of diseases caused by blood stream disorders are also disclosed.

    摘要翻译： 新的二苯基甲烷衍生物可用于抑制血液凝聚，并由式定义，包括二苯基乙烯衍生物和二苯甲酮肟醚衍生物。 其中R 1和R 2各自为氢，羟基或低级烷氧基，U为= XY =或NOW，X为氢，氰基或-COR 6，R6为羟基或氨基，Y为-R10-COOR3，R3 是氢或低级烷氧基，R10是具有1至3个碳原子的直链或支链的亚烷基，-CO-NR4R5，R4和R5各自为氢，低级烷基或低级芳基烷基，-CH2-NHSO2-C6H5或 - C（R8）= NR7，R7为低级烷氧基或芳基，R8为-VR9，V为氧，硫或氮，R9为烷基或芳基，W为-CH2-CO-CH2-COOR13，R13为 氢或低级烷基，-CH 2 -C（= NOR 14）-CH 2 -COOR 15，R 15为氢或低级烷基，R 14为低级烷基，-CH（CN） - （CH 2）q -COOR 16，R 16为氢或 低级烷基，q为1至3的整数，或 - （CH 2）pZ，Z为-SH，-SCN或衍生自五元或六元环的一价基团，其可被具有一个 或更多的硫原子，p为1或2.含有式（ XX）或其药学上可接受的盐作为活性成分，并且还公开了式（XX）化合物或其药学上可接受的盐在制备用于治疗由血液病症引起的疾病的药物中的用途。