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公开(公告)号：EP0704435B1
公开(公告)日：1998-06-24
申请号：EP94921818.4
申请日：1994-07-26
IPC分类号： C07D213/30 , C07D213/61 , C07D417/06 , A61K31/44
CPC分类号： C07D213/30 , C07D417/06
摘要： Intermediates used in producing benzothiazole derivatives useful for preventing and treating diseases against which the activity of inhibiting leucotriene and thromboxane production is efficacious; and a process for producing the same. The process comprises condensing a hydroquinone derivative with a pyridylcarboxaldehyde derivative without protecting the hydroxyl groups of the hydroquinone and oxidizing the formed pyridylmethylhydroquinone derivative into a pyridylmethyl-1,4-benzoquinone derivative.
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公开(公告)号：EP0609442A1
公开(公告)日：1994-08-10
申请号：EP92920995.5
申请日：1992-10-06
申请人： Eisai Co., Ltd.
发明人： KABASAWA, Yasuhiro , OZAKI, Fumihiro , ISHIBASHI, Keiji , HASEGAWA, Takashi , OINUMA, Hitoshi , OGAWA, Toshiaki , ADACHI, Hideyuki , KATOH, Hiroshi , KODAMA, Kohtarou , OHARA, Hideto , MORI, Nobuyuki , MINAMI, Norio
IPC分类号： C07D233/95 , A61K31/435 , A61K31/415 , A61K31/40 , C07D471/04 , A61K31/38 , A61K31/41 , A61K31/495 , A61K31/335 , C07D213/63 , C07D231/12 , C07D249/02 , C07D257/04 , C07D335/02 , C07D275/02 , C07D487/04 , C07D207/327 , C07D409/04 , C07D261/08 , C07D263/10 , C07D333/24 , C07D307/54 , C07D271/12 , C07D235/04 , C07D498/04 , C07D513/04
CPC分类号： C07D233/92 , C07D471/04
摘要： A thioformamide derivative represented by general formula (I), which is highly safe, readily available and useful as excellent hypotensive and a remedy for cardiac diseases, or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the same as the active ingredient, wherein Y represents (a), (b), (c), (d), etc. (wherein R⁷ represents benzyloxy, etc.; R¹¹ and R¹² represent each hydrogen, hydroxy, benzoyloxy, benzyloxy, (e) (wherein R¹⁴ and R¹⁵ represent each hydrogen, benzyl, etc.), etc.); Z represents -CH₂-, etc.; A represents imidazolyl or imidazopyridyl each of which may have one or two substituents, etc.; R¹ and R² represent each hydrogen, lower alkyl, etc.; and R³ and R⁴ represent each hydrogen, lower alkyl, etc.
摘要翻译： 由通式（I）代表的硫代甲酰胺衍生物，其是高度安全的，容易获得的并且可用作心脏疾病的优良降血压药和治疗药或其药理学上可接受的盐，以及含有该活性成分的药物组合物，其中 Y表示（a），（b），（c），（d）等（其中R 7表示苄氧基等; R 1和R 1均表示氢 ，羟基，苯甲酰氧基，苄氧基，（e）（其中R 1和R 5各自表示氢，苄基等）等）。 Z表示-CH 2 - 等; A表示咪唑基或咪唑并吡啶，其各自可具有一个或两个取代基等; R 1和R 2代表每个氢，低级烷基等; R 3和R 4各自代表氢，低级烷基等
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公开(公告)号：EP0704435A1
公开(公告)日：1996-04-03
申请号：EP94921818.4
申请日：1994-07-26
IPC分类号： C07D213/30 , C07D213/61 , C07D417/06 , A61K31/44
CPC分类号： C07D213/30 , C07D417/06
摘要： Intermediates used in producing benzothiazole derivatives useful for preventing and treating diseases against which the activity of inhibiting leucotriene and thromboxane production is efficacious; and a process for producing the same. The process comprises condensing a hydroquinone derivative with a pyridylcarboxaldehyde derivative without protecting the hydroxyl groups of the hydroquinone and oxidizing the formed pyridylmethylhydroquinone derivative into a pyridylmethyl-1,4-benzoquinone derivative.
摘要翻译： 用于生产苯并噻唑衍生物的中间体，用于预防和治疗抑制白三烯和血栓素生成的活性有效的疾病; 及其制造方法。 该方法包括使氢醌衍生物与吡啶基甲醛衍生物缩合而不保护氢醌的羟基并将形成的吡啶基甲基氢醌衍生物氧化成吡啶基甲基-1,4-苯醌衍生物。
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