公开(公告)号：EP1507773B1

公开(公告)日：2015-09-16

申请号：EP03721353.5

申请日：2003-03-07

申请人： Eisai R&D Management Co., Ltd.

发明人： BOIVIN, Roch ,  CHIBA, Kenichi ,  MURAMOTO, Kenzo ,  SHIROTA, Hiroshi ,  DU, Hong ,  EGUCHI, Yoshihito ,  FUJITA, Masanori ,  GUSOVSKY, Fabian ,  GOTO, Masaki ,  HARMANGE, Jean-Christophe ,  INOUE, Atsushi ,  JIANG, Yimin ,  KAWADA, Megumi ,  KAWAI, Takatoshi ,  KAWAKAMI, Yoshiyuki ,  KIMURA, Akifumi ,  KOTAKE, Makoto ,  KUBOI, Yoshikazu ,  LEMELIN, Charles-André ,  LI, Xiang-Yi ,  MATSUSHIMA, Tomohiro ,  MIZUI, Yoshiharu ,  SAKURAI, Hideki ,  CHOW, Jesse ,  SHEN, Yong-Chun ,  SPYVEE, Mark ,  TANAKA, Isao ,  WANG, John (Yuan) ,  YAMAMOTO, Satoshi ,  YONEDA, Naoki ,  KOBAYASHI, Seiichi

IPC分类号： C07D313/00 ,  A61K31/335 ,  A61P29/00 ,  C07D225/06 ,  C07D407/12 ,  C07D491/04 ,  C07D267/00 ,  C07D493/04 ,  A61K31/36 ,  A61K31/395 ,  A61P11/06 ,  A61P17/06 ,  A61P17/16 ,  A61P19/04 ,  A61P35/00 ,  A61P37/06

CPC分类号： C07D405/12 ,  A61K31/335 ,  A61K31/36 ,  A61K31/395 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D313/00 ,  C07D401/12 ,  C07D491/04 ,  C07D491/044 ,  C07D493/04 ,  Y02A50/411

摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein.