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公开(公告)号：EP3362454A1
公开(公告)日：2018-08-22
申请号：EP16790486.1
申请日：2016-10-14
发明人： ZHENG, Wanjun , ZHU, Xiaojie , DU, Hong , POSTEMA, Maarten , JIANG, Yimin , LI, Jing , YU, Robert , CHOI, Hyeong-Wook , LEE, Jaemoon , FANG, Frank , CUSTAR, Daniel
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , A61P35/00 , C07D519/00
摘要： We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.
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公开(公告)号：EP1507773B1
公开(公告)日：2015-09-16
申请号：EP03721353.5
申请日：2003-03-07
发明人： BOIVIN, Roch , CHIBA, Kenichi , MURAMOTO, Kenzo , SHIROTA, Hiroshi , DU, Hong , EGUCHI, Yoshihito , FUJITA, Masanori , GUSOVSKY, Fabian , GOTO, Masaki , HARMANGE, Jean-Christophe , INOUE, Atsushi , JIANG, Yimin , KAWADA, Megumi , KAWAI, Takatoshi , KAWAKAMI, Yoshiyuki , KIMURA, Akifumi , KOTAKE, Makoto , KUBOI, Yoshikazu , LEMELIN, Charles-André , LI, Xiang-Yi , MATSUSHIMA, Tomohiro , MIZUI, Yoshiharu , SAKURAI, Hideki , CHOW, Jesse , SHEN, Yong-Chun , SPYVEE, Mark , TANAKA, Isao , WANG, John (Yuan) , YAMAMOTO, Satoshi , YONEDA, Naoki , KOBAYASHI, Seiichi
IPC分类号： C07D313/00 , A61K31/335 , A61P29/00 , C07D225/06 , C07D407/12 , C07D491/04 , C07D267/00 , C07D493/04 , A61K31/36 , A61K31/395 , A61P11/06 , A61P17/06 , A61P17/16 , A61P19/04 , A61P35/00 , A61P37/06
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein.
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公开(公告)号：EP2182941B1
公开(公告)日：2018-02-28
申请号：EP08796672.7
申请日：2008-07-25
发明人： AGOULNIK, Sergei , DECOSTA, Bruce , DU, Hong , JIANG, Yimin , LI, Xiang-Yi , NOMOTO, Kenichi , WANG, John (Yuan) , ZHANG, Huiming
IPC分类号： A61K31/365 , C07D313/00 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要： The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
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4.发明公开MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER 有权MULTIKINASE HEMMER ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2182941A2
公开(公告)日：2010-05-12
申请号：EP08796672.7
申请日：2008-07-25
发明人： AGOULNIK, Sergei , DECOSTA, Bruce , DU, Hong , JIANG, Yimin , LI, Xiang-Yi , NOMOTO, Kenichi , WANG, John (Yuan) , ZHANG, Huiming
IPC分类号： A61K31/365 , C07D313/00 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/365 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4523 , A61K31/496 , A61K31/5377 , A61K31/665 , A61K45/06
摘要： The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
摘要翻译： 本发明提供用于治疗特定癌症的化合物，药物组合物和方法。 这样的组合物通常可以包含式（I）的化合物：其中R 1 -R 3如本文所定义，或其药学上可接受的盐或酯; 和药学上可接受的载体。
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