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公开(公告)号：EP1507773B1
公开(公告)日：2015-09-16
申请号：EP03721353.5
申请日：2003-03-07
发明人： BOIVIN, Roch , CHIBA, Kenichi , MURAMOTO, Kenzo , SHIROTA, Hiroshi , DU, Hong , EGUCHI, Yoshihito , FUJITA, Masanori , GUSOVSKY, Fabian , GOTO, Masaki , HARMANGE, Jean-Christophe , INOUE, Atsushi , JIANG, Yimin , KAWADA, Megumi , KAWAI, Takatoshi , KAWAKAMI, Yoshiyuki , KIMURA, Akifumi , KOTAKE, Makoto , KUBOI, Yoshikazu , LEMELIN, Charles-André , LI, Xiang-Yi , MATSUSHIMA, Tomohiro , MIZUI, Yoshiharu , SAKURAI, Hideki , CHOW, Jesse , SHEN, Yong-Chun , SPYVEE, Mark , TANAKA, Isao , WANG, John (Yuan) , YAMAMOTO, Satoshi , YONEDA, Naoki , KOBAYASHI, Seiichi
IPC分类号： C07D313/00 , A61K31/335 , A61P29/00 , C07D225/06 , C07D407/12 , C07D491/04 , C07D267/00 , C07D493/04 , A61K31/36 , A61K31/395 , A61P11/06 , A61P17/06 , A61P17/16 , A61P19/04 , A61P35/00 , A61P37/06
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein.
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公开(公告)号：EP2000465B1
公开(公告)日：2010-12-15
申请号：EP07739256.1
申请日：2007-03-22
发明人： CLARK, Richard , MATSUURA, Fumiyoshi , KIRA, Kazunobu , HIROTA, Shinsuke , AZUMA, Hiroshi , NAGAKURA, Tadashi , HORIZOE, Tatsuo , TABATA, Kimiyo , KUSANO, Kazutomi , OMAE, Takao , INOUE, Atsushi
IPC分类号： C07D249/12 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/538 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： Compounds of the general formula (1), salts thereof and their hydrates. (1) In the formula, each of R1a, R1b, R1c and R1d independently is a hydrogen atom, etc. R2 is an optionally substituted phenyl, etc. R3 is an optionally substituted C6-10 aryl, etc. Each of Z1 and Z2 independently is a hydrogen atom. They are useful as a therapeutic agent and/or preventive for diseases caused by clot formation, being safer, and have appropriate physicochemical stability.
摘要翻译： 通式（1）的化合物，其盐及其水合物。 （1）式中，R 1a，R 1b，R 1c和R 1d各自独立地为氢原子等.R 2为任选取代的苯基等.R 3为任选取代的C 6-10芳基等。Z 1和Z 2 独立地是氢原子。 它们可用作治疗剂和/或预防由凝块形成引起的疾病，更安全并具有适当的物理化学稳定性。
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公开(公告)号：EP2000465A1
公开(公告)日：2008-12-10
申请号：EP07739256.1
申请日：2007-03-22
发明人： CLARK, Richard , MATSUURA, Fumiyoshi , KIRA, Kazunobu , HIROTA, Shinsuke , AZUMA, Hiroshi , NAGAKURA, Tadashi , HORIZOE, Tatsuo , TABATA, Kimiyo , KUSANO, Kazutomi , OMAE, Takao , INOUE, Atsushi
IPC分类号： C07D249/12 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/538 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability.
[wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc.; R 2 represents optionally substituted phenyl, etc.; R 3 represents optionally substituted C6-10 aryl, etc.; and Z 1 and Z 2 each independently represent hydrogen]摘要翻译： 由以下通式（1）表示的化合物，其盐或前述水合物是用于治疗和/或预防与血栓形成相关的疾病的新型化合物，并且其具有合适的物理化学稳定性更安全。 [其中R1a，R1b，R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R3代表任选取代的C6-10芳基等; Z1和Z2各自独立地表示氢]
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