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公开(公告)号：EP3484621A1
公开(公告)日：2019-05-22
申请号：EP17828363.6
申请日：2017-07-12
发明人： LEVNER, Daniel , HINOJOSA, Christopher, David , WEN, Norman , FRASER, Jacob , NGUYEN, Justin , BARRILE, Riccardo , HAMILTON, Geraldine , KARALIS, Catherine , PARK, Hyoung Shin , VARONE, Antonio , VAN DER MEER, Andries , OTIENO, Monicah , CONEGLIANO, David
IPC分类号： B01L3/00
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公开(公告)号：EP3504319A1
公开(公告)日：2019-07-03
申请号：EP17847365.8
申请日：2017-08-29
发明人： KERNS, S., Jordan , WEN, Norman , LUCCHESI, Carol , HINOJOSA, Christopher , FRASER, Jacob , HAMILTON, Geraldine , VATINE, Gad , SANCES, Samuel , SVENDSEN, Clive , LEVNER, Daniel , SAREEN, Dhruv
IPC分类号： C12N5/071 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N15/85
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公开(公告)号：EP3484991A1
公开(公告)日：2019-05-22
申请号：EP17828406.3
申请日：2017-07-12
申请人： Emulate, Inc.
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公开(公告)号：EP3411470A2
公开(公告)日：2018-12-12
申请号：EP17748084.5
申请日：2017-02-01
发明人： KERNS, S. Jordan , WEN, Norman , LUCCHESI, Carol , HINOJOSA, Christopher David , FRASER, Jacob , PUERTA, Jefferson , HAMILTON, Geraldine , BARRETT, Robert , SVENDSEN, Clive , LEVNER, Daniel , TARGAN, Stephen R. , WORKMAN, Michael , SAREEN, Dhruv , RAJAMANI, Uthra , KASENDRA, Magdalena
IPC分类号： C12N5/02 , C12N5/074 , C12N5/0793 , C12N5/0797
CPC分类号： C12N5/0696 , C12M23/16 , C12N5/0679 , C12N2501/11 , C12N2501/119 , C12N2501/16 , C12N2501/24 , C12N2501/415 , C12N2501/998 , C12N2506/45 , C12N2535/00
摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
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公开(公告)号：EP3365424A1
公开(公告)日：2018-08-29
申请号：EP16858141.1
申请日：2016-10-19
发明人： KERNS, S., Jordan , WEN, Norman , LUCCHESI, Carol , HINOJOSA, Chris , FRASER, Jacob , HAMILTON, Geraldine , VATINE, Gad , SANCES, Samuel , SVENDSEN, Clive , LEVNER, Daniel , SAREEN, Dhruv
IPC分类号： C12M1/34 , C12M3/00 , C12N5/0793 , C12N5/0797
CPC分类号： C12M23/16 , B01L3/5027 , B01L2200/0647 , B01L2300/0861 , C12M25/02 , C12M35/08 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/069 , C12N5/0692 , C12N2502/081 , C12N2502/086 , C12N2502/28 , C12N2506/45 , C12N2531/00 , C12N2533/52 , C12N2533/54 , C12N2533/56 , C12N2535/10 , C12N2539/00 , C12Q1/02
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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