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公开(公告)号：EP2758052B9
公开(公告)日：2019-03-27
申请号：EP12831417.6
申请日：2012-09-14
申请人： EURO-CELTIQUE S.A.
发明人： CHEN, Yu , YANG, Lan , FENG, Feiyu , GE, Qiufu , GUO, Dianwu , CHEN, Yi
IPC分类号： A61K47/50 , A61K47/40 , A61K31/4184 , A61K31/4164 , A61K31/16 , A61P35/00 , A61K9/19 , A61K9/00 , C07D235/16
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公开(公告)号：EP2758052A2
公开(公告)日：2014-07-30
申请号：EP12831417.6
申请日：2012-09-14
申请人： EURO-CELTIQUE S.A.
发明人： CHEN, Yu , YANG, Lan , FENG, Feiyu , GE, Qiufu , GUO, Dianwu , CHEN, Yi
IPC分类号： A61K31/4184 , A61K31/4164 , A61K31/16 , A61P35/00
CPC分类号： C07D235/16 , A61K9/0019 , A61K9/19 , A61K31/16 , A61K31/4184 , A61K47/40 , A61K47/6951 , Y02A50/414
摘要： The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X1, X2, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.
摘要翻译： 本发明涉及药物组合物，其包含：（a）环多糖和（b）式（I）化合物或其药学上可接受的盐：其中X 1，X 2，Q，Z和m如本文所定义。 还公开了用这些组合物治疗肿瘤疾病或免疫疾病的方法。
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公开(公告)号：EP2760860B1
公开(公告)日：2016-11-16
申请号：EP12836986.5
申请日：2012-09-27
申请人： Euro-Celtique S.A.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14
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公开(公告)号：EP2809657A1
公开(公告)日：2014-12-10
申请号：EP13702055.8
申请日：2013-01-31
申请人： EURO-CELTIQUE S.A.
IPC分类号： C07D235/30 , A61K31/4184 , C07D235/14
CPC分类号： C07D235/30 , A61K31/4184 , A61K45/06 , C07D235/14 , C07D235/18 , Y02A50/414 , A61K2300/00
摘要： The present invention relates to a class of hydroxamic acid compounds of Formula (I), which act as alkylating agents and/or inhibitors of the HDAC pathway, having potential utility in the treatment of a neoplastic disease and immune diseases.
摘要翻译： 本发明涉及一类作为烷化剂和/或HDAC途径的抑制剂的式（I）的异羟肟酸化合物，具有潜在的用途来治疗肿瘤疾病和免疫疾病。
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公开(公告)号：EP2809657B1
公开(公告)日：2017-09-06
申请号：EP13702055.8
申请日：2013-01-31
申请人： EURO-CELTIQUE S.A.
IPC分类号： A61K45/06 , C07D235/18 , C07D235/30 , C07D235/14 , A61K31/4184
CPC分类号： C07D235/30 , A61K31/4184 , A61K45/06 , C07D235/14 , C07D235/18 , Y02A50/414 , A61K2300/00
摘要： The present invention relates to a class of hydroxamic acid compounds of Formula (I), which act as alkylating agents and/or inhibitors of the HDAC pathway, having potential utility in the treatment of a neoplastic disease and immune diseases.
摘要翻译： 本发明涉及一类式（I）的异羟肟酸化合物，其作为HDAC途径的烷化剂和/或抑制剂，在治疗肿瘤疾病和免疫疾病中具有潜在的用途。
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公开(公告)号：EP2760860B8
公开(公告)日：2017-03-08
申请号：EP12836986.5
申请日：2012-09-27
申请人： Euro-Celtique S.A.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14
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公开(公告)号：EP2760860A2
公开(公告)日：2014-08-06
申请号：EP12836986.5
申请日：2012-09-27
申请人： Euro-Celtique S.A.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14
摘要： The disclosure includes compounds of Formula (1): wherein X
1 , X
2 , Q, Z, R
1 , and R
2 are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.-
8.发明授权Pharmaceutical composition comprising an HDAC inhibitor and a cyclopolysaccharide 有权包含HDAC抑制剂和环多糖的药物组合物
公开(公告)号：EP2758052B1
公开(公告)日：2018-02-14
申请号：EP12831417.6
申请日：2012-09-14
申请人： EURO-CELTIQUE S.A.
发明人： CHEN, Yu , YANG, Lan , FENG, Feiyu , GE, Qiufu , GUO, Dianwu , CHEN, Yi
IPC分类号： A61K47/50 , A61K47/40 , A61K31/4184 , A61K31/4164 , A61K31/16 , A61P35/00 , A61K9/19 , A61K9/00 , C07D235/16
CPC分类号： C07D235/16 , A61K9/0019 , A61K9/19 , A61K31/16 , A61K31/4184 , A61K47/40 , A61K47/6951 , Y02A50/414
摘要： The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X 1 , X 2 , Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.
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公开(公告)号：EP2389375B1
公开(公告)日：2015-05-20
申请号：EP10733747.9
申请日：2010-01-07
申请人： Euro-Celtique S.A.
IPC分类号： C07D405/04 , C07D317/72 , C07D319/08 , C07D235/08 , A61K31/357 , A61K31/495 , A61P35/00 , A61P37/02
CPC分类号： C07F15/0013 , A61K31/4184 , C07C259/06 , C07D235/16 , C07D235/26 , C07D235/28 , C07D235/30 , C07D239/10 , C07D239/46 , C07D239/47 , C07D405/04 , C07F15/0093 , Y02A50/414
摘要： The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.
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