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公开(公告)号：EP4356135A1
公开(公告)日：2024-04-24
申请号：EP22735381.0
申请日：2022-06-17
IPC分类号： G01N33/543 , C07K14/00
CPC分类号： G01N33/54353 , G01N2333/24520130101 , C07K14/195 , C07K2319/0020130101 , C07K2319/2120130101
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2.发明公开
公开(公告)号：EP1345628A2
公开(公告)日：2003-09-24
申请号：EP01984811.8
申请日：2001-12-08
发明人： BURG, Josef , ENGEL, Alfred , FRANZE, Reinhard , HILGER, Bernd , SCHURIG, Hartmut, Ernst , TISCHER, Wilhelm , WOZNY, Manfred
IPC分类号： A61K47/48
摘要： The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal α-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula -CO-(CH2)x-(OCH2CH2)m-OR with the -CO of the poly(ethylene glycol) group forming an amide bond with said N-terminal α-amino group; wherein R is lower alkyl; x is 2 or 3; and m is from about 450 to about 1350.
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公开(公告)号：EP4107182A1
公开(公告)日：2022-12-28
申请号：EP21705555.7
申请日：2021-02-19
申请人： Universiteit Maastricht , F. Hoffmann-La Roche AG , Roche Diagnostics GmbH , Academisch ziekenhuis Maastricht
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公开(公告)号：EP3017041B1
公开(公告)日：2019-11-06
申请号：EP14735569.7
申请日：2014-07-03
发明人： CZABANY, Tibor , ENGEL, Alfred , GREIF, Michael , JUNG, Christine , LULEY, Christiane , MALIK, Sebastian , MUELLER, Rainer , NIDETZKY, Bernd , RIBITSCH, Doris , SCHMOELZER, Katharina , SCHWAB, Helmut , SOBEK, Harald , SUPPMANN, Bernhard , THOMANN, Marco , ZITZENBACHER, Sabine
IPC分类号： C12N9/10
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公开(公告)号：EP3485281A1
公开(公告)日：2019-05-22
申请号：EP17745137.4
申请日：2017-07-13
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6.发明授权A SOLUBLE COMPLEX COMPRISING A RETROVIRAL SURFACE GLYCOPROTEIN AND FKPA OR SLYD 有权逆转录病毒表面的糖蛋白和OR FkpA的SlyD含有可溶性络合物
公开(公告)号：EP1402015B1
公开(公告)日：2011-08-31
申请号：EP02758265.9
申请日：2002-06-24
IPC分类号： C12N9/90
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)- chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively are also described.
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公开(公告)号：EP3781600A1
公开(公告)日：2021-02-24
申请号：EP19715804.1
申请日：2019-04-16
发明人： DUEFEL, Hartmut , ENGEL, Alfred , KRONER, Frank , MEIER, Thomas , RUTZ, Sandra , SCHRAEML, Michael , TABARES, Gloria , KURTKAYA, Ulrike , PINCHUK, Boris , ZIMMERMANN, Christina
IPC分类号： C07K16/40 , G01N33/577
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公开(公告)号：EP3359966B1
公开(公告)日：2020-01-01
申请号：EP16778831.4
申请日：2016-10-10
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9.发明授权
公开(公告)号：EP1345628B1
公开(公告)日：2011-04-13
申请号：EP01984811.8
申请日：2001-12-08
发明人： BURG, Josef , ENGEL, Alfred , FRANZE, Reinhard , HILGER, Bernd , SCHURIG, Hartmut, Ernst , TISCHER, Wilhelm , WOZNY, Manfred
IPC分类号： A61K47/48
摘要： The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal α-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula -CO-(CH2)x-(OCH2CH2)m-OR with the -CO of the poly(ethylene glycol) group forming an amide bond with said N-terminal α-amino group; wherein R is lower alkyl; x is 2 or 3; and m is from about 450 to about 1350.
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10.发明公开
公开(公告)号：EP1402015A2
公开(公告)日：2004-03-31
申请号：EP02758265.9
申请日：2002-06-24
IPC分类号： C12N9/90
CPC分类号： G01N33/56988 , A61K39/00 , A61K47/64 , C07K14/005 , C07K2319/00 , C12N9/90 , C12N2740/16122 , G01N33/54306 , G01N33/56911 , G01N33/56983 , G01N2333/005 , G01N2333/16 , G01N2333/195 , G01N2469/20
摘要： The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein- (or transmembrane glycoprotein)- chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively are also described.
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