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公开(公告)号：EP1868999B1
公开(公告)日：2009-07-01
申请号：EP06725329.4
申请日：2006-03-27
发明人： HEBEISEN, Paul , IDING, Hans , NETTEKOVEN, Matthias Heinrich , OBST, Ulrike , ROEVER, Stephan , WIRZ, Beat
IPC分类号： C07D213/64 , C07D213/74 , A61P25/34 , A61P3/00 , A61K31/465
CPC分类号： C07D213/64 , C07D213/74 , C07D213/82 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of the formula (I) wherein X and R1 to R8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors, such as obesity.
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公开(公告)号：EP1474391A1
公开(公告)日：2004-11-10
申请号：EP03737293.5
申请日：2003-01-30
发明人： ALIG, Leo , GROEBKE ZBINDEN, Katrin , OBST, Ulrike
IPC分类号： C07D211/22 , C07D211/42 , C07D211/46 , A61K31/4465 , A61P7/02
CPC分类号： C07D211/22 , C07D211/42
摘要： The invention is concerned with novel water soluble N-(4-carbamimidoyl-phenyl)- glycine derivatives of Formula (I); wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, Ixa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
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公开(公告)号：EP1149069B1
公开(公告)日：2004-08-25
申请号：EP99962221.0
申请日：1999-12-06
发明人： ACKERMANN, Jean , ALIG, Leo , CHUCHOLOWSKI, Alexander , GROEBKE, Katrin , HILPERT, Kurt , KUEHNE, Holger , OBST, Ulrike , WEBER, Lutz , WESSEL, Hans, Peter
IPC分类号： C07C257/18 , C07C259/18 , C07D295/155 , C07D211/46 , A61K31/155 , A61K31/40 , A61K31/435 , C07D211/96 , C07D309/12 , C07D213/74 , A61K31/34 , A61P7/02 , C07C255/59
CPC分类号： C07D207/27 , C07C257/18 , C07C259/18 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D209/48 , C07D211/46 , C07D211/58 , C07D211/96 , C07D213/30 , C07D213/55 , C07D213/65 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/18 , C07D249/08 , C07D261/04 , C07D271/06 , C07D277/24 , C07D295/155 , C07D307/12 , C07D307/20 , C07D307/54 , C07D309/12 , C07D309/14 , C07D317/64 , C07D319/18 , C07D321/10 , C07D333/24 , C07D335/04 , C07D403/12
摘要： The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I), wherein R?1, E, X1 to X4 and G1 and G2¿ are as defined in the description and the claims, as well as hydrates or solvates and physiologically usable salts thereof.
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公开(公告)号：EP1567498B1
公开(公告)日：2008-01-23
申请号：EP03767602.0
申请日：2003-11-21
发明人： BANNER, David, William , GOBBI, Luca, Claudio , GROEBKE ZBINDEN, Katrin , OBST, Ulrike , STAHL, Christoph, Martin
IPC分类号： C07D213/56 , C07D213/65 , C07D213/30 , C07D271/06 , C07D239/42 , C07D213/38 , C07D213/73 , C07C257/18 , C07C259/18 , C07C243/38 , C07C271/66 , C07D211/46 , C07D309/12 , C07D265/36 , C07D295/14 , C07D521/00 , C07D311/04 , A61K31/155
CPC分类号： C07C257/18 , C07C259/18 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/65 , C07D213/73 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D265/36 , C07D271/06 , C07D295/15 , C07D309/12 , C07D311/04
摘要： The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
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公开(公告)号：EP1868999A1
公开(公告)日：2007-12-26
申请号：EP06725329.4
申请日：2006-03-27
发明人： HEBEISEN, Paul , IDING, Hans , NETTEKOVEN, Matthias Heinrich , OBST, Ulrike , ROEVER, Stephan , WIRZ, Beat
IPC分类号： C07D213/64 , C07D213/74 , A61P25/34 , A61P3/00 , A61K31/465
CPC分类号： C07D213/64 , C07D213/74 , C07D213/82 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of the formula (I) wherein X and R1 to R8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors, such as obesity.
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公开(公告)号：EP1149069A1
公开(公告)日：2001-10-31
申请号：EP99962221.0
申请日：1999-12-06
发明人： ACKERMANN, Jean , ALIG, Leo , CHUCHOLOWSKI, Alexander , GROEBKE, Katrin , HILPERT, Kurt , KUEHNE, Holger , OBST, Ulrike , WEBER, Lutz , WESSEL, Hans, Peter
IPC分类号： C07C257/18 , C07C259/18 , C07D295/155 , C07D211/46 , A61K31/155 , A61K31/40 , A61K31/435 , C07D211/96 , C07D309/12 , C07D213/74 , A61K31/34 , A61P7/02 , C07C255/59
CPC分类号： C07D207/27 , C07C257/18 , C07C259/18 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D209/48 , C07D211/46 , C07D211/58 , C07D211/96 , C07D213/30 , C07D213/55 , C07D213/65 , C07D213/74 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/18 , C07D249/08 , C07D261/04 , C07D271/06 , C07D277/24 , C07D295/155 , C07D307/12 , C07D307/20 , C07D307/54 , C07D309/12 , C07D309/14 , C07D317/64 , C07D319/18 , C07D321/10 , C07D333/24 , C07D335/04 , C07D403/12
摘要： The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of formula (I), wherein R?1, E, X1 to X4 and G1 and G2¿ are as defined in the description and the claims, as well as hydrates or solvates and physiologically usable salts thereof.
摘要翻译： 本发明涉及下式的新型N-（4-甲脒基 - 苯基） - 甘氨酸衍生物：其中R 1，E，X 1至X 4和G 1和G 2是 如在说明书和权利要求书中所定义的，以及其水合物或溶剂合物及其生理上可用的盐。
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公开(公告)号：EP1567498A2
公开(公告)日：2005-08-31
申请号：EP03767602.0
申请日：2003-11-21
发明人： BANNER, David, William , GOBBI, Luca, Claudio , GROEBKE ZBINDEN, Katrin , OBST, Ulrike , STAHL, Christoph, Martin
IPC分类号： C07D213/56 , C07D213/65 , C07D213/30 , C07D271/06 , C07D239/42 , C07D213/38 , C07D213/73 , C07C257/18 , C07C259/18 , C07C243/38 , C07C271/66 , C07D211/46 , C07D309/12 , C07D265/36 , C07D295/14 , C07D521/00 , C07D311/04 , A61K31/155
CPC分类号： C07C257/18 , C07C259/18 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/65 , C07D213/73 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D265/36 , C07D271/06 , C07D295/15 , C07D309/12 , C07D311/04
摘要： The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
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公开(公告)号：EP1303486A1
公开(公告)日：2003-04-23
申请号：EP01956523.3
申请日：2001-07-10
发明人： AEBI, Johannes , BUR, Daniel , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , KITAS, Eric, Argirios , OBST, Ulrike , WESSEL, Hans, Peter
IPC分类号： C07D207/48 , C07D207/36 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D401/12 , C07D403/06 , A61K31/40 , A61P9/00
CPC分类号： C07D401/12 , C07D207/36 , C07D207/48 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： The present invention relates to compounds of formula (I) wherein R?1, R2, R3, R4, R5, R6¿, Y, n, m, o. p and q are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
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9.发明公开PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME 审中-公开吡咯烷酮衍生物ALS内皮素KONVERTIERENDE ENZYMINHIBITOREN
公开(公告)号：EP1303485A1
公开(公告)日：2003-04-23
申请号：EP01949485.5
申请日：2001-07-10
发明人： AEBI, Johannes , BLUM, Denise , BUR, Daniel , CHUCHOLOWSKI, Alexander , DEHMLOW, Henrietta , KITAS, Eric, Argirios , LOEFFLER, Bernd, Michael , OBST, Ulrike , WALLBAUM, Sabine
IPC分类号： C07D207/12 , C07D207/16 , C07D207/48 , C07D409/12 , C07D403/12 , C07D401/06 , A61K31/40 , A61P9/10 , A61P9/12 , A61P39/06
CPC分类号： C07D401/12 , C07D207/12 , C07D207/16 , C07D207/48 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, A, X and m are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors or metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
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公开(公告)号：EP1289939A1
公开(公告)日：2003-03-12
申请号：EP01960221.8
申请日：2001-05-17
发明人： ALIG, Leo , GROEBKE ZBINDEN, Katrin , HILPERT, Kurt , KUEHNE, Holger , OBST, Ulrike , WESSEL, Hans, Peter
IPC分类号： C07C257/18 , C07C259/18 , C07D307/20 , A61K31/155 , A61P7/02
CPC分类号： C07D317/36 , C07C257/18 , C07C259/18 , C07D307/20
摘要： The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R1 to R5 are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologically acceptable salts thereof and/or physiologically acceptable esters thereof.
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