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    METHOD OF ANALYZING DYNAMICS IN THE DIFFERENTIATION OF VASCULAR ENDOTHELIAL PROGENITOR CELLS
    1.
    发明公开
    METHOD OF ANALYZING DYNAMICS IN THE DIFFERENTIATION OF VASCULAR ENDOTHELIAL PROGENITOR CELLS 审中-公开
    VERFAHREN ZUR DYNAMIKANALYSE BEI DER DIFFERENZIERUNGVASKULÄRERENDOTHORVORLÄUFERZELLEN

    公开(公告)号：EP1860196A1

    公开(公告)日：2007-11-28

    申请号：EP06714938.5

    申请日：2006-02-22

    申请人： Foundation for Biomedical Research and Innovation ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

    发明人： ASAHARA, T. Institute of Biomed. Res. & Innovation ,  MASUDA, Haruchika

    IPC分类号： C12Q1/02 ,  C12N5/02

    CPC分类号： G01N33/6872 ,  C12N5/0692 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/165 ,  C12N2501/23 ,  C12N2501/91 ,  G01N33/5005 ,  G01N33/5064 ,  G01N2333/475 ,  G01N2333/503

    摘要： The present invention provides a method of forming an EPC colony with good reproducibility, and a method of analyzing the dynamics of EPC differentiation in the body of patient. More specifically, the present invention provides a method of analyzing the dynamics of differentiation of endothelial progenitor cells, which includes culturing hemangioblasts in a semisolid medium containing a vascular endothelial growth factor and a basic fibroblast growth factor, and evaluating the mode of endothelial progenitor cell colony formation; a method of forming an endothelial progenitor cell colony which includes culturing hemangioblasts in a semisolid medium containing a vascular endothelial growth factor and a basic fibroblast growth factor; a semisolid medium containing a vascular endothelial growth factor and a basic fibroblast growth factor; and a kit for preparing the semisolid medium and the like.

    摘要翻译： 本发明提供了形成具有良好重现性的EPC集落的方法，以及分析患者体内EPC分化动力学的方法。 更具体地，本发明提供了分析内皮祖细胞分化动力学的方法，其包括在含有血管内皮生长因子和碱性成纤维细胞生长因子的半固体培养基中培养成血管细胞，并评估内皮祖细胞集落的模式 形成; 形成内皮祖细胞集落的方法，其包括在含有血管内皮生长因子和碱性成纤维细胞生长因子的半固体培养基中培养成血管细胞; 含有血管内皮生长因子和碱性成纤维细胞生长因子的半固体培养基; 以及用于制备半固体培养基等的试剂盒。

    METHOD FOR IN VITRO PROLIFERATION OF CELL POPULATION CONTAINING CELLS SUITABLE FOR TREATMENT OF ISCHEMIC DISEASE
    2.
    发明公开
    METHOD FOR IN VITRO PROLIFERATION OF CELL POPULATION CONTAINING CELLS SUITABLE FOR TREATMENT OF ISCHEMIC DISEASE 审中-公开
    VERFAHREN ZUR IN-VITRO-PROLIFERATION VON ZELLPOPULATION MIT ZELLEN ZUR BEHANDLUNGISCHÄMISCHERERKRANKUNGEN

    公开(公告)号：EP2902483A1

    公开(公告)日：2015-08-05

    申请号：EP13842351.2

    申请日：2013-09-30

    申请人： Foundation for Biomedical Research and Innovation ,  Tokai University Educational System ,  Stemmed Inc. ,  Juntendo Educational Foundation

    发明人： ASAHARA, Takayuki ,  MASUDA, Haruchika ,  TANAKA, Rika

    IPC分类号： C12N5/077 ,  A61K35/14 ,  A61K35/28 ,  A61P3/10 ,  A61P9/10 ,  A61P17/02 ,  C12N5/078

    摘要： Simplification of a preparation step of a cell population used for the treatment of ischemic diseases, and provision of a cell population that shows more effect by the treatment.
    A method of producing a cell population wherein a vascular endothelial progenitor cell and/or an anti-inflammatory macrophage are/is enriched, including cultivating a mononuclear cell derived from bone marrow, cord blood or peripheral blood in a serum-free medium containing stem cell factor, interleukin-6, FMS-like tyrosine kinase 3 ligand, thrombopoietin and vascular endothelial cell growth factor, and proliferating vascular endothelial progenitor cell from the cell; and a cell population obtained by the method, etc.

    摘要翻译： 简化用于治疗缺血性疾病的细胞群的制备步骤，以及提供通过治疗显示更多效果的细胞群。 一种生产细胞群的方法，其中富含血管内皮祖细胞和/或抗炎巨噬细胞，包括在含有干细胞的无血清培养基中培养源自骨髓，脐带血或外周血的单核细胞 因子，白介素-6，FMS样酪氨酸激酶3配体，血小板生成素和血管内皮细胞生长因子，以及来自细胞的增殖性血管内皮祖细胞; 和通过该方法得到的细胞群等

    METHOD FOR AMPLIFICATION OF ENDOTHELIAL PROGENITOR CELL IN VITRO
    3.
    发明公开
    METHOD FOR AMPLIFICATION OF ENDOTHELIAL PROGENITOR CELL IN VITRO 审中-公开
    VERFAHREN ZUR AMPLIFIKATION EINER内皮素激素

    公开(公告)号：EP1860180A1

    公开(公告)日：2007-11-28

    申请号：EP06714935.1

    申请日：2006-02-22

    申请人： Foundation for Biomedical Research and Innovation ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

    发明人： ASAHARA, Takayuki,c/oDept.Reg.Med., Inst.Bio.Res. ,  MASUDA, Haruchika

    IPC分类号： C12N5/00 ,  A61K35/12 ,  A61P9/10 ,  C12N5/06

    CPC分类号： A61K35/44 ,  C12N5/0692 ,  C12N2500/90 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2501/23 ,  C12N2501/26 ,  C12N2506/11

    摘要： The present invention provides a method for expanding an endothelial progenitor cell in vitro. More particularly, the present invention provides a method for culturing a hemangioblast comprising incubating a hemangioblast in a serum-free culture medium containing one or more factors selected from the group consisting of stem cell growth factor, interleukin-6, FMS-like tyrosine kinase 3 and thrombopoietin, and a vascular endothelial cell produced by the method; and a serum-free culture medium containing one or more factors selected from the group consisting of stem cell growth factor, interleukin-6, FMS-like tyrosine kinase 3 and thrombopoietin, and a kit for the preparation of the serum-free culture medium and the like.

    摘要翻译： 本发明提供了体外扩张内皮祖细胞的方法。 更具体地说，本发明提供培养成血成血管细胞的方法，包括在含有一种或多种选自干细胞生长因子，白细胞介素-6，FMS样酪氨酸激酶3的因素的无血清培养基中培养成血成血管细胞 和血小板生成素，以及通过该方法产生的血管内皮细胞; 和含有选自干细胞生长因子，白细胞介素-6，FMS样酪氨酸激酶3和血小板生成素的一种或多种因子的无血清培养基，以及用于制备无血清培养基的试剂盒和 类似。