公开(公告)号：EP2988682A1

公开(公告)日：2016-03-02

申请号：EP13756036.3

申请日：2013-08-22

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Albert-Ludwigs-Universität Freiburg

发明人： GRUNWALD, Ingo ,  RICHTER, Katharina ,  MIERNIK, Arkadiusz ,  SCHOENTHALER, Martin

IPC分类号： A61B17/22 ,  A61K47/36 ,  A61L24/00 ,  A61L24/04

CPC分类号： A61L31/022 ,  A61B17/22 ,  A61B17/221 ,  A61B2017/00876 ,  A61L31/042 ,  A61L31/14 ,  A61L31/145 ,  A61L2300/102 ,  A61L2400/06 ,  C08L5/04 ,  C08L5/06

摘要： Described is a kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, comprising a composition (A) comprising one or more cationically crosslinkable polymers, and a composition (B) comprising one or more crosslinking agents for crosslinking the cationically crosslinkable polymer(s). The compositions (A) and/or (B) further comprise magnetizable particles, or the kit further comprises a composition (C) that comprises magnetizable particles. On contact between compositions (A) and (B) in a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, and that comprises the magnetizable particles. The gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, can then be removed from the body by using magnetic interactions.

公开(公告)号：EP2988682B1

公开(公告)日：2017-02-08

申请号：EP13756036.3

申请日：2013-08-22

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Albert-Ludwigs-Universität Freiburg

发明人： GRUNWALD, Ingo ,  RICHTER, Katharina ,  MIERNIK, Arkadiusz ,  SCHOENTHALER, Martin

IPC分类号： A61B17/22 ,  A61K47/36 ,  A61L24/00 ,  A61L24/04

CPC分类号： A61L31/022 ,  A61B17/22 ,  A61B17/221 ,  A61B2017/00876 ,  A61L31/042 ,  A61L31/14 ,  A61L31/145 ,  A61L2300/102 ,  A61L2400/06 ,  C08L5/04 ,  C08L5/06

公开(公告)号：EP2988681A1

公开(公告)日：2016-03-02

申请号：EP13756034.8

申请日：2013-08-22

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Albert-Ludwigs-Universität Freiburg

发明人： GRUNWALD, Ingo ,  RICHTER, Katharina ,  MIERNIK, Arkadiusz ,  SCHOENTHALER, Martin

IPC分类号： A61B17/22 ,  A61K47/36 ,  A61L24/00 ,  A61L24/04

CPC分类号： A61L24/08 ,  A61B17/22 ,  A61B2017/00876 ,  A61B2017/22082 ,  A61L24/0031 ,  A61L24/02 ,  A61L24/04 ,  A61L2430/26

摘要： Described primarily are gel-forming systems consisting of or comprising a composition (A), comprising one or more cationically crosslinkable polymers, and a composition (B), comprising one or more crosslinking agents for crosslinking the cationically crosslinkable polymer(s), for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, comprising the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s) on contact between compositions (A) and (B), to form a crosslinked gel that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, (iii) removing the crosslinked gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are surrounded with it from the urinary tract, more particularly the kidney.

公开(公告)号：EP2895858B1

公开(公告)日：2016-11-23

申请号：EP13760057.3

申请日：2013-09-13

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： SZARDENINGS, Michael ,  GRUNWALD, Ingo ,  RISCHKA, Klaus ,  RICHTER, Katharina

IPC分类号： C12Q1/26 ,  A61K47/48 ,  G01N33/532

CPC分类号： C12Q1/26 ,  A61K47/542 ,  G01N33/532 ,  G01N33/533

公开(公告)号：EP2895858A1

公开(公告)日：2015-07-22

申请号：EP13760057.3

申请日：2013-09-13

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： SZARDENINGS, Michael ,  GRUNWALD, Ingo ,  RISCHKA, Klaus ,  RICHTER, Katharina

IPC分类号： G01N33/533 ,  A61K47/48

CPC分类号： C12Q1/26 ,  A61K47/542 ,  G01N33/532 ,  G01N33/533

摘要： Method for marking a target structure, comprising the steps of: a) providing a compound V which comprises at least one dihydroxy- or trihydroxyphenyl group, b) providing a means for converting the dihydroxy- or trihydroxyphenyl group into a quinone group, c) providing a target structure, d) oxidizing the dihydroxy- or trihydroxyphenyl group of compound V to form the quinone group, and e) establishing contact between compound V and the target structure, with the result that a covalent bond can be formed, characterized in that, in step e), compound V is used in a concentration such that the maximum concentration of dihydroxy-, trihydroxyphenyl groups and quinone groups which have been introduced by compound V is ≤500 µM, preferably ≤300 µM, more preferably ≤100 µM.