公开(公告)号：EP2110002A4

公开(公告)日：2010-03-03

申请号：EP08728244

申请日：2008-01-25

Applicant: GEN HOSPITAL CORP ,  CAMBRIDGE POLYMER GROUP INC

Inventor： MURATOGLU ORHUN K ,  KOPESKY EDWARD T ,  ORAL EBRU

IPC: H05B6/00 ,  C08F2/46

CPC classification number: A61L27/505 ,  A61L27/16 ,  B29C43/003 ,  B29C43/18 ,  B29C71/04 ,  B29K2023/0683 ,  B29K2105/20 ,  B29K2995/0056 ,  B29L2031/753 ,  C08F10/02 ,  C08F110/02 ,  C08J3/24 ,  C08J3/28 ,  C08J2323/06 ,  C08K5/1545 ,  C08K2201/012 ,  C08F2/46 ,  C08F2500/01

Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (±-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (±-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.

公开(公告)号：EP2125906A4

公开(公告)日：2014-07-16

申请号：EP08731238

申请日：2008-03-03

Applicant: GEN HOSPITAL CORP ,  CAMBRIDGE POLYMER GROUP INC

Inventor： MURATOGLU ORHUN K ,  SPIEGELBERG STEPHEN H

IPC: C08J3/28 ,  A61L27/16 ,  A61L29/04 ,  A61L31/04 ,  C08J3/22 ,  C08K5/00 ,  C08K5/1545 ,  C08L23/06

CPC classification number: A61L27/16 ,  A61L27/505 ,  A61L29/041 ,  A61L29/143 ,  A61L31/048 ,  A61L2430/02 ,  C08J3/226 ,  C08J3/247 ,  C08J3/28 ,  C08J2323/06 ,  C08J2423/00 ,  C08K5/1545 ,  C08K2201/012 ,  C08L23/06 ,  C08L2666/02 ,  C08K5/005

Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.

公开(公告)号：EP1750614A4

公开(公告)日：2011-10-26

申请号：EP05750134

申请日：2005-05-10

Applicant: GEN HOSPITAL CORP ,  CAMBRIDGE POLYMER GROUP INC

Inventor： MURATOGLU ORHUN K ,  SPIEGELBERG STEPHEN H

IPC: A61L27/16 ,  A61F2/00 ,  A61L27/50

CPC classification number: A61L27/16 ,  A61L27/505 ,  C08L23/06 ,  C08L23/10 ,  C08L27/06 ,  C08L67/00 ,  C08L77/00 ,  C08L2312/06

公开(公告)号：EP1596755A4

公开(公告)日：2011-03-16

申请号：EP04702484

申请日：2004-01-15

Applicant: MASSACHUSETTS GEN HOSPITAL ,  CAMBRIDGE POLYMER GROUP INC

Inventor： MURATOGLU ORHUN K ,  SPIEGELBERG STEPHEN H

IPC: A61B20060101 ,  A61F2/00 ,  A61F2/958 ,  A61L27/16 ,  A61L27/50 ,  C08K5/34

CPC classification number: B29C35/0805 ,  A61L27/16 ,  A61L27/505 ,  A61L29/041 ,  A61L29/143 ,  A61L31/048 ,  A61L31/143 ,  B29C43/003 ,  C08J3/28 ,  C08K5/005 ,  C08K5/1545 ,  C08L23/06 ,  C08L2312/06 ,  Y10T29/49 ,  Y10T29/49995 ,  Y10T428/31855

Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

公开(公告)号：EP2166991A4

公开(公告)日：2013-12-18

申请号：EP08799839

申请日：2008-04-24

Applicant: GEN HOSPITAL CORP

Inventor： CHOI JEEYOUNG ,  MURATOGLU ORHUN K

IPC: A61F2/30 ,  A61L27/16 ,  A61L27/26 ,  A61L31/04 ,  C08J3/075 ,  C08L29/04 ,  C08L33/02 ,  C08L71/02

CPC classification number: A61L27/26 ,  A61L27/16 ,  A61L27/52 ,  C08J3/075 ,  C08J2329/04 ,  C08L29/04 ,  C08L33/02 ,  C08L71/02 ,  C08L2666/02

Abstract: The invention provides fabricated PVA-hydrogels, PVA-hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the PVA-hydrogels, or the PVA-hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked PVA-hydrogels, and cross-linked PVA-hydrogel-containing compositions also are disclosed herein.

公开(公告)号：EP1720485A4

公开(公告)日：2012-01-25

申请号：EP05712671

申请日：2005-02-03

Applicant: GEN HOSPITAL CORP

Inventor： MURATOGLU ORHUN K ,  ORAL EBRU

IPC: A61F2/38 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/40 ,  A61L27/16 ,  A61L27/50 ,  B29C43/00 ,  C08F2/46 ,  C08J3/28 ,  C08K5/01

CPC classification number: B29C35/08 ,  A61F2/30 ,  A61L27/16 ,  A61L27/50 ,  B29C43/003 ,  B29K2023/0683 ,  B29K2023/083 ,  B29L2031/7532 ,  C08J3/28 ,  C08J2323/06 ,  Y10T29/4998 ,  C08L23/06

公开(公告)号：EP2193018A4

公开(公告)日：2011-01-26

申请号：EP08829042

申请日：2008-09-04

Applicant: GEN HOSPITAL CORP

Inventor： MURATOGLU ORHUN K ,  BODUGOZ-SENTURK HATICE

IPC: C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08L29/04

CPC classification number: C08J3/28 ,  C08J3/075 ,  C08J3/246 ,  C08J2329/04

公开(公告)号：EP2672916A4

公开(公告)日：2015-01-14

申请号：EP12744158

申请日：2012-02-08

Applicant: GEN HOSPITAL CORP

Inventor： MALCHAU HENRIK ,  BRAITHWAITE GAVIN ,  MURATOGLU ORHUN K ,  RUBASH HARRY E ,  MILLER BAYEN

IPC: A61B19/00 ,  A61B5/00

CPC classification number: A61B5/1116 ,  A61B5/0022 ,  A61B5/05 ,  A61B5/1114 ,  A61B5/1127 ,  A61B5/4571 ,  A61B5/6823 ,  A61B5/6828 ,  A61B5/683 ,  A61B5/6878 ,  A61B5/70 ,  A61B5/742 ,  A61B34/20 ,  A61B2034/2048 ,  A61B2505/05 ,  A61B2560/0214 ,  A61B2560/0223

公开(公告)号：EP1924614A4

公开(公告)日：2009-08-26

申请号：EP06801836

申请日：2006-08-18

Applicant: GEN HOSPITAL CORP

Inventor： MURATOGLU ORHUN K ,  ORAL EBRU

IPC: C08F10/02 ,  C08L23/06

CPC classification number: C08J3/24 ,  A61L27/16 ,  C08F110/02 ,  C08J3/20 ,  C08J3/28 ,  C08J7/08 ,  C08J2323/06 ,  C08J2371/10 ,  C08J2377/00 ,  C08K5/1545 ,  C08L23/06 ,  C08L2207/068 ,  Y10T428/31692 ,  C08F2500/01 ,  C08F2500/11

Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.

公开(公告)号：EP1919983A4

公开(公告)日：2009-05-13

申请号：EP06801842

申请日：2006-08-18

Applicant: GEN HOSPITAL CORP

Inventor： MURATOGLU ORHUN K ,  ORAL EBRU

IPC: C08J3/28

CPC classification number: C08J5/00 ,  C08J3/28 ,  C08J2300/00 ,  C08J2323/00 ,  Y02P20/544

Abstract: The present invention relates to methods for making oxidation resistant homogenized polymeric materials and medical implants that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and annealing the anti-oxidant doped UHMWPE in a super critical fluid, and materials used therein.