公开(公告)号：EP1171166A1

公开(公告)日：2002-01-16

申请号：EP00922207.6

申请日：2000-04-14

申请人： Diatide, Inc. ,  GENENTECH, INC.

发明人： DEAN, Richard, T. ,  LISTER-JAMES, John ,  VENUTI, Michael, C. ,  SOMERS, Todd, C.

IPC分类号： A61K51/04 ,  C07D243/24

CPC分类号： A61K51/0497 ,  A61K51/047 ,  A61K51/0478

摘要： The invention provides compounds comprising glycoprotein IIb/IIIa receptor-binding benzodiazepine derivatives covalently linked to metal ion chelators. The compounds of the invention may be labeled with a radionuclide such as 99mTc and used to image thrombi.

公开(公告)号：EP0792289B1

公开(公告)日：2000-07-12

申请号：EP95940028.4

申请日：1995-11-16

申请人： GENENTECH, INC.

发明人： SOMERS, Todd, C. ,  ELIAS, Kathleen, A. ,  CLARK, Ross, G. ,  McDOWELL, Robert, S. ,  STANLEY, Mark, S. ,  BURNIER, John, P. ,  RAWSON, Thomas, E.

IPC分类号： C07K14/60 ,  C07K5/023 ,  C07K5/027 ,  C07K5/03 ,  C07K5/087 ,  C07K5/107 ,  C07K5/117

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D209/20 ,  C07D211/62 ,  C07D403/12 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/0207 ,  C07K5/06078 ,  C07K5/0812 ,  C07K5/1016 ,  C07K5/1024 ,  C07K7/06 ,  C07K14/60

摘要： The present invention comprises growth hormone releasing peptides/peptidomimetics (GHRP) capable of causing release of growth hormone from the pituitary. Compositions containing the GHRP's of this invention are used to promote growth in mammals either alone or in combination with other growth promoting compounds, especially IGF-1. In a method of this invention GHRP's in combination with IGF-1 are used to treat Type II diabetes. An exemplary compound (1) of this invention is provided above.

公开(公告)号：EP0792289A1

公开(公告)日：1997-09-03

申请号：EP95940028.0

申请日：1995-11-16

申请人： GENENTECH, INC.

发明人： SOMERS, Todd, C. ,  ELIAS, Kathleen, A. ,  CLARK, Ross, G. ,  McDOWELL, Robert, S. ,  STANLEY, Mark, S. ,  BURNIER, John, P. ,  RAWSON, Thomas, E.

IPC分类号： C07D295 ,  A61K31 ,  A61K38 ,  A61P3 ,  A61P5 ,  C07D209 ,  C07D211 ,  C07D401 ,  C07D403 ,  C07K5 ,  C07K7 ,  C07K14

CPC分类号： C07D401/12 ,  A61K38/00 ,  C07D209/20 ,  C07D211/62 ,  C07D403/12 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/0207 ,  C07K5/06078 ,  C07K5/0812 ,  C07K5/1016 ,  C07K5/1024 ,  C07K7/06 ,  C07K14/60

摘要： The present invention comprises growth hormone releasing peptides/peptidomimetics (GHRP) capable of causing release of growth hormone from the pituitary. Compositions containing the GHRP's of this invention are used to promote growth in mammals either alone or in combination with other growth promoting compounds, especially IGF-1. In a method of this invention GHRP's in combination with IGF-1 are used to treat Type II diabetes. An exemplary compound (1) of this invention is provided above.

公开(公告)号：EP0708775B1

公开(公告)日：1997-05-28

申请号：EP94923512.1

申请日：1994-07-15

申请人： GENENTECH, INC.

发明人： BLACKBURN, Brent, K. ,  ROBARGE, Kirk ,  SOMERS, Todd, C.

IPC分类号： C07D487/04 ,  A61K31/55 ,  C07D519/00

CPC分类号： C07D487/04

摘要： A tricyclic benzodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIbIIIa receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.

公开(公告)号：EP0708775A1

公开(公告)日：1996-05-01

申请号：EP94923512.0

申请日：1994-07-15

申请人： GENENTECH, INC.

发明人： BLACKBURN, Brent, K. ,  ROBARGE, Kirk ,  SOMERS, Todd, C.

IPC分类号： A61K31 ,  A61P7 ,  C07D487 ,  C07D498 ,  C07D507 ,  C07D513

CPC分类号： C07D487/04