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公开(公告)号:EP0441900B1
公开(公告)日:1996-07-17
申请号:EP90901161.1
申请日:1989-11-09
发明人: TRINCHIERI, Giorgio , PERUSSIA, Bice , KOBAYASHI, Michiko , CLARK, Steven, C. , WONG, Gordon, G. , HEWICK, Rodney, M.
CPC分类号: C07K14/5434 , A61K38/00
摘要: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, and pharmaceutical preparation containing it.
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公开(公告)号:EP0441900A1
公开(公告)日:1991-08-21
申请号:EP90901161.0
申请日:1989-11-09
发明人: TRINCHIERI, Giorgio , PERUSSIA, Bice , KOBAYASHI, Michiko , CLARK, Steven, C. , WONG, Gordon, G. , HEWICK, Rodney, M.
IPC分类号: G01N33 , A61K38 , A61K39 , A61P35 , A61P37 , A61P43 , C07K1 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号: C07K14/5434 , A61K38/00
摘要: Nouvelle cytokine humaine homogène, appelée facteur stimulateur de cellules cytotoxiques naturelles, et préparation pharmaceutique la contenant.
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公开(公告)号:EP0487613B1
公开(公告)日:1996-10-30
申请号:EP90913091.6
申请日:1990-08-07
摘要: A novel human megakaryocytopoietic factor capable of stimulating the growth and development of colonies of megakaryocytes is provided, including procedures for its purification and use as a pharmaceutical agent.
摘要翻译: 提供了能够刺激巨核细胞集落生长和发育的新型人类巨核细胞生成因子,包括其纯化和用作药物的程序。
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公开(公告)号:EP0536186B1
公开(公告)日:2001-11-21
申请号:EP91911087.4
申请日:1991-05-15
发明人: HEWICK, Rodney, M. , WANG, Jack, H.
摘要: Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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公开(公告)号:EP0536186A1
公开(公告)日:1993-04-14
申请号:EP91911087.0
申请日:1991-05-15
发明人: HEWICK, Rodney, M. , WANG, Jack, H.
IPC分类号: C12N15 , A61K38 , A61P17 , A61P19 , A61P43 , C07K7 , C07K14 , C12N1 , C12N5 , C12P21 , C12R1
摘要: Protéines purifiées d'induction cartilagineuse et/ou osseuse et leurs procédés de production. On peut utiliser les protéines dans le traitement de problèmes osseux et/ou cartilagineux ainsi que dans la cicatrisation de blessures et la réparation de tissus associés.
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公开(公告)号:EP0205564B2
公开(公告)日:2000-06-21
申请号:EP86900439.0
申请日:1985-12-03
IPC分类号: C12P21/00
CPC分类号: C07K14/505 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2830/85 , C12N2840/44
摘要: Cloned genes for human erythropoietin (EPO) obtained from human fetal liver that provide surprisingly high levels of expression. Also described is the expression of said genes in vitro to produce active human EPO.
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公开(公告)号:EP0567599A1
公开(公告)日:1993-11-03
申请号:EP92907075.0
申请日:1992-01-17
发明人: TURNER, Katherine , CLARK, Steven, C. , JACOBS, Kenneth , HEWICK, Rodney, M. , GESNER, Thomas, G.
摘要: Nouveaux facteurs stimulateurs des mégacaryocytes (MSF) capables de stimuler la croissance et le développement de colonies de mégacaryocytes, compositions pharmaceutiques les contenant et leurs procédés de préparation et d'utilisation.
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公开(公告)号:EP0209539B1
公开(公告)日:1992-05-20
申请号:EP86900400.2
申请日:1985-11-27
CPC分类号: C07K14/505 , A61K38/00 , C07K16/00 , Y10S530/834 , Y10S930/30
摘要: Homogeneous erythropoietin for the first time characterized by an amino acid sequence 1-166 substantially as shown in table 1, molecular weight of about 34,000 daltons, movement as a single peak on reverse phase HPLC, and specific activity of at least 120,000 IU.
摘要翻译: 第一次是均一促红细胞生成素,其特征在于基本上如表1所示的氨基酸序列1-166,分子量约34,000道尔顿,在反相HPLC上作为单峰移动,并且比活性至少为120,000IU。
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公开(公告)号:EP0205564B1
公开(公告)日:1991-05-02
申请号:EP86900439.0
申请日:1985-12-03
IPC分类号: C12P21/00
CPC分类号: C07K14/505 , C12N15/85 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2830/85 , C12N2840/44
摘要: Cloned genes for human erythropoietin (EPO) obtained from human fetal liver that provide surprisingly high levels of expression. Also described is the expression of said genes in vitro to produce active human EPO.
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公开(公告)号:EP0487613A1
公开(公告)日:1992-06-03
申请号:EP90913091.0
申请日:1990-08-07
摘要: L'invention concerne un nouveau facteur mégakaryocytopoïétique humain pouvant stimuler la croissance et le développement de colonies de mégakaryocytes, ainsi que des procédés pour sa purification et son utilisation en tant qu'agent pharmaceutique.
摘要翻译: 本发明提供了可以刺激巨核细胞集落生长和发育的新型人巨核细胞生长因子,以及其纯化和用作药物的方法。
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