公开(公告)号：EP1649028B1

公开(公告)日：2012-08-22

申请号：EP04779179.3

申请日：2004-07-26

申请人： GENVEC, INC. ,  The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： GALL, Jason G., D. ,  WICKHAM, Thomas, J. ,  ENRIGHT, William, J. ,  BROUGH, Douglas, E. ,  ZUBER, Mohammed ,  KING, C., Richter ,  NABEL, Gary J. ,  CHENG, Cheng

IPC分类号： C12N15/861 ,  A61K39/235

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2710/10345

摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80 % or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.

公开(公告)号：EP1294918A2

公开(公告)日：2003-03-26

申请号：EP01950575.9

申请日：2001-06-27

申请人： GENVEC, INC.

发明人： BROUGH, Douglas, E. ,  KING, C., Richter ,  KOVESDI, Imre

IPC分类号： C12N15/861 ,  C12N15/28 ,  C07K14/525 ,  C12N5/10 ,  C12N7/01 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K38/191 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2810/40

摘要： An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.

公开(公告)号：EP1802762A2

公开(公告)日：2007-07-04

申请号：EP05812347.2

申请日：2005-10-17

申请人： GENVEC, INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KING, C., Richter ,  GALL, Jason, G., D. ,  NABEL, Gary, J. ,  CHENG, Cheng

IPC分类号： C12N15/86

CPC分类号： A61K39/0011 ,  A61K39/385 ,  A61K47/64 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  Y02A50/386 ,  Y02A50/412

摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.

公开(公告)号：EP1649028A2

公开(公告)日：2006-04-26

申请号：EP04779179.3

申请日：2004-07-26

申请人： GENVEC, INC.

发明人： GALL, Jason G. D. ,  WICKHAM, Thomas J. ,  ENRIGHT, William, J. ,  BROUGH, Douglas, E. ,  ZUBER, Mohammed ,  KING, C., Richter

IPC分类号： C12N15/861 ,  A61K39/235

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2710/10345

摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80 % or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.

公开(公告)号：EP1294918B1

公开(公告)日：2005-10-12

申请号：EP01950575.9

申请日：2001-06-27

申请人： GenVec, Inc.

发明人： BROUGH, Douglas, E. ,  KING, C., Richter ,  KOVESDI, Imre

IPC分类号： C12N15/861 ,  C12N15/28 ,  C07K14/525 ,  C12N5/10 ,  C12N7/01 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K38/191 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2810/40

摘要： An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.

公开(公告)号：EP1929021A2

公开(公告)日：2008-06-11

申请号：EP06824864.0

申请日：2006-08-31

申请人： GENVEC, INC. ,  The United States of America as Represented by The Secretary of The Navy

发明人： BRUDER, Joseph, T. ,  KOVESDI, Imre ,  KING, C., Richter ,  MCVEY, Duncan, L. ,  ETTYREDDY, Damodar, R. ,  DOOLAN, Denise, Louise ,  CARUCCI, Daniel, John ,  LIMBACH, Keith

IPC分类号： C12N15/861 ,  C07K14/445 ,  A61K39/015

CPC分类号： C07K14/445 ,  A61K39/015 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/008 ,  Y02A50/412

摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.

摘要翻译： 本发明提供包含腺病毒基因组的腺病毒载体，所述腺病毒基因组包含可操作地连接至启动子的编码异源抗原的核酸序列，例如疟原虫核酸序列。 本发明进一步提供了在哺乳动物中诱导针对疟疾的免疫应答的方法，其包括将腺病毒载体给予哺乳动物。

公开(公告)号：EP1737885A2

公开(公告)日：2007-01-03

申请号：EP05778761.6

申请日：2005-04-12

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： NABEL, Gary, J. ,  CHENG, Cheng ,  KONG, Wing-Pui ,  GALL, Jason, G., D. ,  KING, C., Richter

IPC分类号： C07K14/16

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.