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1.发明授权CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权富集在单元格中膦酸酯类似物的HIV蛋白酶抑制剂化合物和接线SELF
公开(公告)号：EP1509537B1
公开(公告)日：2007-07-18
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, W. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
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2.发明公开
公开(公告)号：EP1711617A1
公开(公告)日：2006-10-18
申请号：EP04817046.8
申请日：2004-12-22
发明人： ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu, 377 Laurie Meadows Drive , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos, 2000 Walnut Avenue , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MITCHELL, Michael L. , NELSON, Peter H.
IPC分类号： C12Q1/44
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
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3.发明授权CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权HIV蛋白酶抑制剂化合物及其化合物的膦酸盐类似物的细胞积累
公开(公告)号：EP1509537B9
公开(公告)日：2007-11-14
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, W. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译： 公开了具有用作治疗剂和用于其他工业目的的HIV蛋白酶抑制性质的膦酸酯取代的化合物。 该组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其他抗病毒感染以及用于检测HIV蛋白酶的分析。
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4.发明公开CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权富集在单元格中膦酸酯类似物的HIV蛋白酶抑制剂化合物和接线SELF
公开(公告)号：EP1509537A2
公开(公告)日：2005-03-02
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, M. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
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